|1.||Mauviel, Alain: 3 articles (12/2012 - 04/2002)|
|2.||Go, Jai Hyang: 2 articles (05/2015 - 12/2008)|
|3.||Brückner, Martina K: 2 articles (12/2014 - 12/2012)|
|4.||Rohn, Susanne: 2 articles (12/2014 - 12/2012)|
|5.||Ueberham, Elke: 2 articles (12/2014 - 12/2012)|
|6.||Ueberham, Uwe: 2 articles (12/2014 - 12/2012)|
|7.||Arendt, Thomas: 2 articles (12/2014 - 12/2012)|
|8.||Hilbrich, Isabel: 2 articles (12/2014 - 12/2012)|
|9.||Yang, Xiao: 2 articles (05/2013 - 02/2009)|
|10.||Higashiyama, Reiichi: 2 articles (03/2012 - 07/2005)|
02/01/2015 - "The Mothers Against Decapentaplegic homolog (Smad)-dependent pathway is the main TGF-β1 pathway involved in fibrosis. "
05/01/2012 - "The classic description of TGF-β signaling pathology in renal disease involves signaling through Smad proteins resulting in extracellular matrix deposition and fibrosis. "
01/01/2012 - "Several putative binding sites for the Smad proteins and the Ap1 complex are located in the miR-29 promoter, which are suggested to mediate miR-29 decrease in fibrosis. "
06/01/2009 - "Inflammatory damage and fibrosis were evaluated, and the molecular mechanism was analyzed according to Th1/Th2 balance, Sma- and MAD-related proteins (Smads) and signal transducer and activator of transcriptions (STATs) expression. "
06/01/2011 - "Here we discuss a role for TGF-β as the principle effector in the development of renal fibrosis in diabetic nephropathy, focusing on the role of the TGF-β1 isoform and its downstream signalling intermediates, the Smad proteins. "
06/01/2015 - "Although Smad proteins are conserved, recent genome-sequencing projects have revealed their sequence variation in metazoan evolution, human polymorphisms, and cancer. "
04/01/2013 - "Our results indicate that Smad proteins, particularly Smad7, in oral epithelial dysplasia and SCC could contribute to the attenuation of Smads anti-proliferative signaling in cancer development. "
03/01/2013 - "Our results point out that the SMAD proteins play a role in the microenvironment of this highly fibrotic tumor type."
03/01/2013 - "SMAD proteins also have pro-tumor effects including abnormal extracellular matrix production. "
01/01/2013 - "Accumulating evidence has suggested that Mothers against decapentaplegic homolog 7 (SMAD7) rs12953717 polymorphism might be related to cancer risk. "
05/01/2004 - "In this study, we examined effects of cell adhesion status on the TGF-beta1-mediated Erk1/2 regulation, and roles of Smad proteins on the cell adhesion-mediated effects, using a gastric carcinoma cell variant. "
08/01/2004 - "We found that human pancreatic carcinoma cell lines that have undergone deletion of MADH4 constitutively expressed high endogenous levels of phosphorylated receptor-associated Smad proteins (pR-Smad2 and pR-Smad3), whereas Smad4-positive lines did not. "
03/01/2001 - "[Deletion mapping of chromosome 18q and Smad proteins expression analysis in urinary bladder carcinomas]."
08/01/2000 - "Also, downregulation of Smad proteins is another mechanism by which carcinomas can become independent from TGF-beta-mediated growth inhibition."
01/27/2005 - "Since the TGF-beta response is mediated by Smad proteins and the tumor suppressor gene Smad4 resides at 18q21, we have analysed the Smad4 gene for cervical cancer-associated alterations in cell lines and primary carcinomas. "
|5.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2014 - "Mothers against decapentaplegic homolog 7 (SMAD7) rs12953717 polymorphism has been implicated to alter the risk of colorectal cancer (CRC), but the results are controversial. "
06/01/2009 - "Recent genome-wide scans for colorectal cancer (CRC) have revealed the SMAD7 (mothers against decapentaplegic homolog 7) gene as a locus associated with a modest, but highly significant increase in CRC risk. "
07/19/1999 - "Our data show selective up-regulation of receptor-activated Smad proteins in human colorectal cancers and suggest involvement of Smad4 in differentiation and apoptosis of surface epithelial cells of normal crypts."
07/19/1999 - "Expression of Smad proteins in human colorectal cancer."
05/01/2010 - "Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer."
|1.||Transforming Growth Factors (Transforming Growth Factor)
|3.||Transforming Growth Factor beta (TGF-beta)
|4.||Proteins (Proteins, Gene)
|5.||Activin Receptors (Activin Receptor)