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Sterol Regulatory Element Binding Protein 1

A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Also Known As:
Adipocyte Determination And Differentiation Factor 1; SRE-1 Binding Protein; SREBP-1a; SREBP-1c; SREBP1 Protein; Sterol Regulatory Element Binding Protein 1a; Sterol Regulatory Element Binding Protein 1c; Sterol Regulatory Element-Binding Protein 1; Transcription Factor ADD1; ADD1, Transcription Factor; SRE 1 Binding Protein; SREBP 1a; SREBP 1c
Networked: 233 relevant articles (15 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Shimano, Hitoshi: 13 articles (01/2015 - 01/2002)
2. Yamada, Nobuhiro: 7 articles (08/2011 - 06/2005)
3. Matsuzaka, Takashi: 6 articles (08/2011 - 06/2005)
4. Suzuki, Hiroaki: 5 articles (08/2011 - 06/2005)
5. Nakagawa, Yoshimi: 5 articles (08/2011 - 06/2005)
6. Takahashi, Akimitsu: 5 articles (08/2011 - 06/2005)
7. Yahagi, Naoya: 5 articles (08/2011 - 06/2005)
8. Deng, Xiong: 4 articles (01/2013 - 12/2004)
9. Videla, Luis A: 4 articles (01/2012 - 11/2009)
10. Sone, Hirohito: 4 articles (08/2011 - 06/2005)

Related Diseases

1. Insulin Resistance
2. Hypertriglyceridemia
3. Hyperinsulinism (Hyperinsulinemia)
12/01/2004 - "This study clearly demonstrates that substitution of dietary polyunsaturated fatty acid for carbohydrate in the corpulent JCR:LA-cp rat reduces de novo lipogenesis, at least in part, by reducing hepatic expression of SREBP-1c and that strategies directed toward reducing SREBP-1c expression in the liver may mitigate the adverse effects of hyperinsulinemia on hepatic lipid production."
01/01/2014 - "Hyperinsulinemia induces transcription of SREBP-1c via activation of liver X receptor (LXR) and specificity protein 1 (Sp1). "
05/01/2013 - "Hyperinsulinemia induces SREBP-1c transcription through liver X receptor (LXR), specificity protein 1, and SREBP-1c itself. "
11/01/2011 - "These changes may lead to hepatic steatosis by different mechanisms, namely, (i) IR-dependent higher peripheral lipolysis and FA flux to the liver, (ii) n-3 LCPUFA depletion-induced changes in DNA binding activity of sterol regulatory element-binding protein 1c (SREBP-1c) and peroxisome proliferator-activated receptor α (PPAR-α) favouring lipogenesis over FA oxidation, and (iii) hyperinsulinemia-induced activation of lipogenic factor PPAR-γ. "
05/01/2006 - "L-p85DKO mice failed to activate PI3K or generate PIP(3) upon insulin stimulation or activate its two major effectors, Akt and PKClambda/xi. Decreased Akt activation resulted in increased gluconeogenic gene expression, impaired glucose tolerance, and hyperinsulinemia, while the defective activation of PKClambda/xi by insulin was associated with hypolipidemia and decreased transcription of SREBP-1c. "
4. Obesity
5. Alcoholic Fatty Liver

Related Drugs and Biologics

1. Insulin (Novolin)
2. Glucose (Dextrose)
3. Messenger RNA (mRNA)
4. Fatty Acid Synthetase Complex (Fatty Acid Synthase)
5. Cholesterol
6. Non-alcoholic Fatty Liver Disease
7. Metformin (Glucophage)
8. Dehydroepiandrosterone (DHEA)
9. PPAR gamma
10. Phosphotransferases (Kinase)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Fat-Restricted Diet (Diet, Fat Restricted)
3. Nutrition Therapy (Medical Nutrition Therapy)
4. Laparoscopic Cholecystectomy
5. Ligation