Early Growth Response Protein 2

An early growth response transcription factor that controls the formation of the MYELIN SHEATH around peripheral AXONS by SCHWANN CELLS. Mutations in EGR2 transcription factor have been associated with HEREDITARY MOTOR AND SENSORY NEUROPATHIES such as CHARCOT-MARIE-TOOTH DISEASE.

Also Known As:

Networked: 12 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ahmed, S Ansar: 1 article (01/2022)
2.	Dai, Rujuan: 1 article (01/2022)
3.	Eden, Kristin: 1 article (01/2022)
4.	Heid, Bettina: 1 article (01/2022)
5.	Reilly, Christopher M: 1 article (01/2022)
6.	Wang, Zhuang: 1 article (01/2022)
7.	Amit, Moran: 1 article (11/2021)
8.	Beckedorff, Felipe: 1 article (11/2021)
9.	Benitah, Salvador Aznar: 1 article (11/2021)
10.	Bescós, Coro: 1 article (11/2021)

Related Diseases

1.	Hypoxia (Hypoxemia) 03/10/2016 - "Jaw, brain, and notochord expression was strong with the full-length clone, but was dramatically reduced as the size of the fragment driving the reporter decreased from approximately 1.8 to 0.9 kb. The 2.5 kb region 5' of the sox9b contained 7 conserved non-coding elements (CNEs) that included putative hypoxia inducible factor 1α (HIF1α), CAAT box (CCAAT), early growth response protein 2 (EGR2), and core promoter elements. "
2.	Autoimmune Diseases (Autoimmune Disease) 01/01/2022 - "Previous studies have reported that deletion of the transcription factor, early growth response protein 2 (EGR2), in normal C57BL/6 (B6) resulted in the development of lupus-like autoimmune disease. "
3.	B-Cell Lymphoma (Lymphoma, B Cell) 01/01/2020 - "In silico analyses, dual-luciferase reporter gene and chromatin immunoprecipitation assays were adopted to determine relationships among miR-410, histone deacetylase 1 (HDAC1), early growth response protein 2 (EGR2), and B cell lymphoma/leukemia 2 (Bcl2). "
4.	Seizures (Absence Seizure) 06/01/1994 - "The transcription factor KROX-20, unlike many other immediate early genes, is not expressed in the rat hippocampus after bicuculline induced generalized seizures. " 06/01/1994 - "High induction threshold for transcription factor KROX-20 in the rat brain: partial co-expression with heat shock protein 70 following limbic seizures."
5.	Neurofibromatosis 1 (Neurofibromatosis Type I) 06/01/2004 - "Some genes that were not previously linked to this model, such as bric-a-brac (BTB) and cap-n-collar(CNC) homology 1(BACH1), early growth response protein 2 (EGR2), E47 interaction protein 1 (EIP1), Ngfi-A binding protein 2 (NAB2), myeloblastosis oncogene-like protein (MYBL2), neurofibromatosis 1 (NF1), ciliarry neurotropic factor (CNTF) and semaphorin 4A (Sema4A). "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Proteins (Proteins, Gene)
3.	Histone Deacetylase 1
4.	Semaphorins (Semaphorin)
5.	Ciliary Neurotrophic Factor (CNTF)
6.	Galanin
7.	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)
8.	Messenger RNA (mRNA)
9.	Peptides (Polypeptides)
10.	Myelin Proteins