PAX2 Transcription Factor

A paired box transcription factor that is essential for ORGANOGENESIS of the CENTRAL NERVOUS SYSTEM and KIDNEY.

Also Known As:

Paired Box Gene 2 Protein; Paired Box Protein Pax-2; Paired Box Transcription Factor 2; Transcription Factor PAX2; Factor PAX2, Transcription; PAX2, Transcription Factor; Paired Box Protein Pax 2; Transcription Factor, PAX2

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tong, Guo-Xia: 3 articles (09/2008 - 03/2006)
2.	Hamele-Bena, Diane: 2 articles (09/2008 - 01/2008)
3.	Memeo, Lorenzo: 2 articles (09/2008 - 03/2006)
4.	Aier, Imlimaong: 1 article (04/2021)
5.	Raj, Utkarsh: 1 article (04/2021)
6.	Semwal, Rahul: 1 article (04/2021)
7.	Varadwaj, Pritish Kumar: 1 article (04/2021)
8.	Baligod, Seth: 1 article (01/2021)
9.	Burdette, Joanna E: 1 article (01/2021)
10.	Colina, Jose A: 1 article (01/2021)

Related Diseases

1.	Adenoma (Adenomas) 09/01/2008 - "This new concept has led to the identification of renal transcription factor PAX2 as a diagnostic marker for nephrogenic adenoma. " 01/01/2008 - "This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract. " 03/01/2006 - "In this study, we investigated the expression of a renal transcription factor, PAX2, in 39 nonrenal transplant-related nephrogenic adenomas, 100 adenocarcinomas of the prostate gland, and 47 urothelial carcinomas of the urinary tract. "
2.	Adenocarcinoma 04/01/2021 - "Comparative modeling and structure based drug repurposing of PAX2 transcription factor for targeting acquired chemoresistance in pancreatic ductal adenocarcinoma." 03/01/2006 - "In this study, we investigated the expression of a renal transcription factor, PAX2, in 39 nonrenal transplant-related nephrogenic adenomas, 100 adenocarcinomas of the prostate gland, and 47 urothelial carcinomas of the urinary tract. "
3.	Carcinoma (Carcinomatosis) 03/01/2006 - "In this study, we investigated the expression of a renal transcription factor, PAX2, in 39 nonrenal transplant-related nephrogenic adenomas, 100 adenocarcinomas of the prostate gland, and 47 urothelial carcinomas of the urinary tract. "
4.	Neoplasms (Cancer) 01/01/2021 - "Interestingly, loss of the transcription factor PAX2, which is a common and early alteration in HGSOC, played a pivotal role in the expression of cancer stem-like cells (CSC) markers and cell function. " 02/01/2006 - "The transcription factor Pax2 is known to play a key role during renal development and to act as an oncogene favoring renal tumor growth. " 01/01/2008 - "This has promoted the use of immunostaining of renal transcription factor PAX2 in tissue biopsies to differentiate nephrogenic adenoma from the common malignant tumors of the lower urinary tract. " 11/20/2009 - "We have examined the possible correlation between cancer stem cell (CSC)-like markers (CD133, paired box gene 2 protein (PAX2), epithelial specific antigen (ESA)), and a new membrane estrogen receptor (G-protein coupled receptor 30 (GPR30)) in invasive ductal breast carcinomas with known clinicopathological parameters, tumor recurrence, and expression of some known biomarkers. "
5.	Papillorenal syndrome 04/01/2008 - "Papillorenal syndrome is an autosomal-dominant disease caused by mutations in the PAX2 transcription factor gene. " 08/01/2000 - "Some of these disorders are associated with congenital anomalies in multiple organ systems, and two such syndromes are considered in detail: first, the renal-coloboma syndrome, in which mutations of the PAX2 transcription factor cause partial failure of urinary tract growth; second, Kallmann's syndrome, in which mutations of a cell-signaling molecule are associated with the absence of the urinary tract. " 03/01/2003 - "The renal-coloboma syndrome is an autosomal dominant human disease, secondary to mutation of the PAX2 transcription factor, characterized by optic nerve coloboma, renal anomalies and vesicoureteral reflux. "

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