Xeroderma Pigmentosum Group D Protein

A DNA helicase that is a component of TRANSCRIPTION FACTOR TFIIH. It plays an essential role in NUCLEOTIDE EXCISION REPAIR, and mutations in this protein are associated with XERODERMA PIGMENTOSUM.

Also Known As:

ERCC2 Protein; Excision Repair Cross-Complementing Rodent Repair Deficiency, Group 2 Protein; Xeroderma Pigmentosum Complementation Group D Protein; Excision Repair Cross Complementing Rodent Repair Deficiency, Group 2 Protein

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chi, Xin-Xin: 1 article (01/2015)
2.	Cong, Zhuang: 1 article (01/2015)
3.	Liang, Yu-Qing: 1 article (01/2015)
4.	Liu, You-Yu: 1 article (01/2015)
5.	Shi, Su-Ning: 1 article (01/2015)
6.	Zhang, Hui-Jun: 1 article (01/2015)
7.	Cassel, Tobias: 1 article (11/2010)
8.	Helleday, Thomas: 1 article (11/2010)
9.	Savolainen, Linda: 1 article (11/2010)
10.	Cai, Sanjun: 1 article (08/2010)

Related Diseases

1.	Cataract (Cataracts) 01/01/2015 - "Various combinations of the keywords and MeSH terms were used to screen for potentially relevant studies, specifically "genetic polymorphisms" or "SNPs" or "variation" or "single nucleotide polymorphism" or "polymorphism" or "mutation" or "variant"; "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "XPD" or "Xeroderma Pigmentosum Complementation Group D Protein" or "ERCC2" or "XRCC1" or "XRCC1 DNA repair protein"; and "Cataract" or " Membranous Cataract" or " Pseudoaphakia." Meta-analyses were conducted using Stata 12.0 software. "
2.	Breast Neoplasms (Breast Cancer) 08/01/2010 - "Studies on polymorphisms of Xeroderma Pigmentosum Group D Protein (XPD) and breast cancer risk are inconclusive. "
3.	Skin Neoplasms (Skin Cancer) 11/01/2010 - "The role of Xeroderma Pigmentosum group D protein (XPD) in nucleotide excision repair explains the increased risk of skin cancer in XP patients but not all the clinical phenotypes found in XP/CS or TTD patients. "

Related Drugs and Biologics

1.	Xeroderma Pigmentosum Group D Protein
2.	X-ray Repair Cross Complementing Protein 1