|1.||Egly, Jean-Marc: 5 articles (02/2015 - 02/2004)|
|2.||Compe, Emmanuel: 2 articles (02/2015 - 12/2009)|
|3.||Stefanini, Miria: 2 articles (02/2015 - 07/2004)|
|4.||Ueda, Takahiro: 2 articles (12/2009 - 11/2006)|
|5.||Kraemer, Kenneth H: 2 articles (12/2009 - 11/2006)|
|6.||Raams, Anja: 2 articles (11/2006 - 07/2004)|
|7.||Egly, J M: 2 articles (09/2001 - 11/2000)|
|8.||Duan, H O: 2 articles (03/2001 - 03/2000)|
|9.||Lee, D K: 2 articles (03/2001 - 03/2000)|
|10.||Chang, C: 2 articles (03/2001 - 03/2000)|
|1.||Xeroderma Pigmentosum (Kaposi's Disease)
05/29/2015 - "Xeroderma pigmentosum group D (XPD) helicase is a component of the transcription factor IIH (TFIIH) transcription complex and plays essential roles in transcription and nucleotide excision repair. "
01/01/2013 - "TTD is caused primarily by mutations in the xeroderma pigmentosum group D (XPD) gene, which encodes a subunit of the basal transcription factor IIH. "
10/12/2010 - "A key NER intermediate involves unwinding of the damaged duplex by transcription factor TFIIH, a reaction that requires xeroderma pigmentosum group D (XPD) protein. "
12/21/2009 - "Mutations in the XPD subunit of the DNA repair/transcription factor TFIIH result in the rare recessive genetic disorder xeroderma pigmentosum (XP). "
01/09/1998 - "Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein."
02/03/2015 - "Mutations in the XPD subunit of the DNA repair/transcription factor TFIIH result in distinct clinical entities, including the cancer-prone xeroderma pigmentosum (XP) and the multisystem disorder trichothiodystrophy (TTD), which share only cutaneous photosensitivity. "
11/20/1997 - "Of these, the XPB and XPD genes encode proteins that are subunits of a general transcription factor, TFIIH, involved in both nucleotide excision repair (NER) and initiation of mRNA transcription by RNA polymerase II. In humans, mutation of the XPB or XPD gene impairs NER, resulting in hyper-sensitivity to sunlight and greatly increased skin tumor formation. "
01/01/2010 - "Genes/regions statistically significantly associated with CIN3/cancer included the viral infection and cell entry genes 2',5' oligoadenylate synthetase gene 3 (OAS3), sulfatase 1 (SULF1), and interferon gamma (IFNG); the DNA repair genes deoxyuridine triphosphate (DUT), dosage suppressor of mck 1 homolog (DMC1), and general transcription factor IIH, polypeptide 3 (GTF2H4); and the EVER1 and EVER2 genes (p<0.01). "
03/01/1996 - "Human cells from patients suffering with xeroderma pigmentosum (XP) characterized by extreme sensitivity to UV light and a high incidence of skin tumors fall into seven complementation groups, XPA to XPG, and are lacking a functional helicase, endonuclease, or lesion-recognizing protein involved in the initial steps during nucleotide excision repair (NER); a number of proteins involved in DNA repair are termed XPA to XPG depending on which one is defective in a particular complementation group of XP and include: (i) proteins involved in the recognition of (6-4) photoproducts (XPE) and of a broad range of lesions such as pyrimidine dimers (XPA); (ii) proteins that are DNA helicases and integral parts of the general transcription factor TFIIH functioning in both transcription and repair (XPB, XPD); (iii) endonucleases that perform the two incisions, the XPG incising six nucleotides (nt) to the 3' side from a photodimer and the ERCC1-XPF protein complex incising 22 nt to the 5' side of the lesion; and (iv) single-strand DNA-binding proteins (XPC). "
|3.||Cockayne Syndrome (Syndrome, Cockayne)
01/15/2013 - "Specific mutations in the XPD subunit of transcription factor IIH result in combined xeroderma pigmentosum (XP)/Cockayne syndrome (CS), a severe DNA repair disorder characterized at the cellular level by a transcriptional arrest following UV irradiation. "
10/01/1996 - "Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome."
10/23/1998 - "RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62."
07/01/1996 - "Mutations in the Cockayne syndrome genes (the CSA and CSB genes acting for preferential repair of active genes by interacting with transcription factor TFIIH) and in the ataxia telangictasia gene ATM (homologous with PI-3 kinase for signal transduction) have been disclosed. "
|4.||DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
02/03/2005 - "The gene responsible for the TTD-A group of the DNA repair deficient disease trichothiodystrophy has been identified as a small, 8 kDa, component of the transcription factor TFIIH which contributes to the stability and concentration of TFIIH in vivo."
07/01/2004 - "DNA repair-deficient trichothiodystrophy (TTD) results from mutations in the XPD and XPB subunits of the DNA repair and transcription factor TFIIH. "
|5.||Prostatic Neoplasms (Prostate Cancer)
03/30/2001 - "Our previous report demonstrated that the AR interacted with transcription factor IIH (TFIIH) under physiological conditions and that overexpression of Cdk-activating kinase, the kinase moiety of TFIIH, enhanced AR-mediated transcription in prostate cancer cells. "
03/31/2000 - "Co-immunoprecipitation of prostate cancer LNCaP cell extract using protein A-Sepharose coupled with anti-AR antibody indicates that the AR interacts with the general transcription factor TFIIH in a physiological condition. "
|1.||DNA (Deoxyribonucleic Acid)
|2.||RNA Polymerase II (RNA Polymerase B)
|3.||Proteins (Proteins, Gene)
|4.||A-Form DNA (A-DNA)
|7.||DNA-Binding Proteins (DNA Binding Protein)
|9.||cyclin-dependent kinase-activating kinase (Cdk-activating kinase)