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Transcription Factor TFIIH

A general transcription factor that is involved in basal GENETIC TRANSCRIPTION and NUCLEOTIDE EXCISION REPAIR. It consists of nine subunits including ATP-DEPENDENT DNA HELICASES; CYCLIN H; and XERODERMA PIGMENTOSUM GROUP D PROTEIN.
Also Known As:
BTF2 Transcription Factor; Basic Transcription Factor 2; Transcription Factor BTF2; Transcription Factor IIH; BTF2, Transcription Factor; TFIIH, Transcription Factor; Transcription Factor, BTF2; Transcription Factor, TFIIH; TFIIH Transcription Factor
Networked: 39 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Egly, Jean-Marc: 5 articles (02/2015 - 02/2004)
2. Compe, Emmanuel: 2 articles (02/2015 - 12/2009)
3. Stefanini, Miria: 2 articles (02/2015 - 07/2004)
4. Ueda, Takahiro: 2 articles (12/2009 - 11/2006)
5. Kraemer, Kenneth H: 2 articles (12/2009 - 11/2006)
6. Raams, Anja: 2 articles (11/2006 - 07/2004)
7. Egly, J M: 2 articles (09/2001 - 11/2000)
8. Duan, H O: 2 articles (03/2001 - 03/2000)
9. Lee, D K: 2 articles (03/2001 - 03/2000)
10. Chang, C: 2 articles (03/2001 - 03/2000)

Related Diseases

1. Xeroderma Pigmentosum (Kaposi's Disease)
2. Neoplasms (Cancer)
02/03/2015 - "Mutations in the XPD subunit of the DNA repair/transcription factor TFIIH result in distinct clinical entities, including the cancer-prone xeroderma pigmentosum (XP) and the multisystem disorder trichothiodystrophy (TTD), which share only cutaneous photosensitivity. "
11/20/1997 - "Of these, the XPB and XPD genes encode proteins that are subunits of a general transcription factor, TFIIH, involved in both nucleotide excision repair (NER) and initiation of mRNA transcription by RNA polymerase II. In humans, mutation of the XPB or XPD gene impairs NER, resulting in hyper-sensitivity to sunlight and greatly increased skin tumor formation. "
01/01/2010 - "Genes/regions statistically significantly associated with CIN3/cancer included the viral infection and cell entry genes 2',5' oligoadenylate synthetase gene 3 (OAS3), sulfatase 1 (SULF1), and interferon gamma (IFNG); the DNA repair genes deoxyuridine triphosphate (DUT), dosage suppressor of mck 1 homolog (DMC1), and general transcription factor IIH, polypeptide 3 (GTF2H4); and the EVER1 and EVER2 genes (p<0.01). "
03/01/1996 - "Human cells from patients suffering with xeroderma pigmentosum (XP) characterized by extreme sensitivity to UV light and a high incidence of skin tumors fall into seven complementation groups, XPA to XPG, and are lacking a functional helicase, endonuclease, or lesion-recognizing protein involved in the initial steps during nucleotide excision repair (NER); a number of proteins involved in DNA repair are termed XPA to XPG depending on which one is defective in a particular complementation group of XP and include: (i) proteins involved in the recognition of (6-4) photoproducts (XPE) and of a broad range of lesions such as pyrimidine dimers (XPA); (ii) proteins that are DNA helicases and integral parts of the general transcription factor TFIIH functioning in both transcription and repair (XPB, XPD); (iii) endonucleases that perform the two incisions, the XPG incising six nucleotides (nt) to the 3' side from a photodimer and the ERCC1-XPF protein complex incising 22 nt to the 5' side of the lesion; and (iv) single-strand DNA-binding proteins (XPC). "
3. Cockayne Syndrome (Syndrome, Cockayne)
4. DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
5. Prostatic Neoplasms (Prostate Cancer)

Related Drugs and Biologics

1. DNA (Deoxyribonucleic Acid)
2. RNA Polymerase II (RNA Polymerase B)
3. Proteins (Proteins, Gene)
4. A-Form DNA (A-DNA)
5. Phosphotransferases (Kinase)
6. Trichothiodystrophy
7. DNA-Binding Proteins (DNA Binding Protein)
8. DNA Helicases
9. cyclin-dependent kinase-activating kinase (Cdk-activating kinase)
10. Cyclin H