B-Cell-Specific Activator Protein

A transcription factor that is essential for CELL DIFFERENTIATION of B-LYMPHOCYTES. It functions both as a transcriptional activator and repressor to mediate B-cell commitment.
Also Known As:
B Cell-Specific Transcription Factor; Early B Cell-Specific Binding Protein-1; PAX5 Transcription Factor; Pax5A Transcription Factor; B Cell Specific Activator Protein; B Cell Specific Transcription Factor; Early B Cell Specific Binding Protein 1; Transcription Factor, PAX5; Transcription Factor, Pax5A
Networked: 33 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results


1. Medeiros, L Jeffrey: 3 articles (02/2012 - 04/2004)
2. Zhao, Tong: 3 articles (03/2004 - 11/2002)
3. Dong, Henry Y: 2 articles (12/2006 - 05/2005)
4. Rassidakis, George Z: 2 articles (08/2006 - 04/2004)
5. Lin, Pei: 2 articles (08/2006 - 10/2004)
6. Falini, Brunangelo: 2 articles (10/2004 - 01/2002)
7. Zhu, Mei-gang: 2 articles (03/2004 - 10/2003)
8. Zhou, Xinhua: 2 articles (03/2004 - 11/2002)
9. Yu, Jiang: 2 articles (03/2004 - 10/2003)
10. Shen, Xin-ming: 2 articles (03/2004 - 10/2003)

Related Diseases

1. Neoplasms (Cancer)
02/01/2013 - "  The purpose of this study was to evaluate the expression patterns of B-cell specific activator protein (BSAP)/PAX5 and PAX8 in a wide variety of B-cell and T-cell neoplasms. "
05/01/2009 - "Possible explanations of PAX5 staining include aberrant expression of the PAX5 transcription factor, PAX5 expression in normal tissue at the time the tumors most closely recapitulates in development or crossreactivity with another member of the PAX family. "
01/15/2002 - "The protein products of other genes activated by chromosomal rearrangement have a role as markers of either lineage (eg, PAX-5 [B-cell-specific activator protein] for B cells, including B-lymphoblastic neoplasms), or maturation stage (eg, BCL-6 for germinal-center and activated B cells and MUM-1/IRF4 for plasma cells). "
04/01/2004 - "Also, recently developed antibodies (eg, the antibody specific for PAX-5/B-cell-specific activator protein [BSAP]) provide new, sensitive tools for identifying neoplasms of B-cell lineage that can morphologically resemble ALCL. "
06/19/2002 - "Mouse splenic and thymic lymphocytes and tumor tissues were analyzed for the expression of cytokines involved in inflammatory and immune responses, including tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), basic fibroblast growth factor (bFGF), and interleukin 12 (IL-12); for the activation of the transcription factors nuclear factor-kappaB (NF-kappaB) and the B cell-specific transcription factor Oct-2; and for the activation of the Src and Syk family kinases, components of B-cell receptor-induced signal-transduction pathways. "
2. Small Cell Lung Carcinoma (Small Cell Lung Cancer)
3. Bipolar Disorder (Mania)
4. Lymphoma (Lymphomas)
5. Hodgkin Disease (Hodgkin's Disease)

Related Drugs and Biologics

1. STF 62247
2. Transcription Factors (Transcription Factor)
3. Messenger RNA (mRNA)
4. CD19 Antigens
5. Interleukin-12 (IL 12)
6. NF-kappa B (NF-kB)
7. Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
8. Cytokines
9. Interleukin-6 (Interleukin 6)
10. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)