ZAP-70 Protein-Tyrosine Kinase (ZAP 70 Protein Tyrosine Kinase)

A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.

Also Known As:

ZAP 70 Protein Tyrosine Kinase; 70 kDa Zeta-Associated Protein; Syk-Related Tyrosine Kinase; ZAP-70 Kinase; ZAP-70 Protein; zeta-Chain Associated Protein Kinase (ZAP-70); 70 kDa Zeta Associated Protein; Kinase, ZAP-70; Protein-Tyrosine Kinase, ZAP-70; Syk Related Tyrosine Kinase; Tyrosine Kinase, Syk-Related; ZAP 70 Kinase; ZAP 70 Protein

Networked: 23 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fan, Lei: 3 articles (06/2012 - 07/2009)
2.	Li, Jian-Yong: 3 articles (06/2012 - 07/2009)
3.	Xu, Wei: 3 articles (06/2012 - 07/2009)
4.	Cao, Xin: 2 articles (12/2009 - 07/2009)
5.	Liu, Qiong: 2 articles (12/2009 - 07/2009)
6.	Miao, Kou-Rong: 2 articles (12/2009 - 07/2009)
7.	Qiao, Chun: 2 articles (12/2009 - 07/2009)
8.	Wu, Yu-Jie: 2 articles (12/2009 - 07/2009)
9.	Efremov, Dimitar G: 2 articles (12/2007 - 11/2005)
10.	Gobessi, Stefania: 2 articles (12/2007 - 11/2005)

Related Diseases

1.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 05/01/2009 - "To study the clinicopathologic features and prognostic significance of ZAP-70 protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). " 11/24/2020 - "Flow Cytometric Analysis of ZAP-70 Protein Expression for B-Cell Chronic Lymphocytic Leukemia Prognostication: Usefulness and Limitations." 01/01/2015 - "Recently, A6 has been shown to be directly cytotoxic for B-lymphocytes obtained from patients with chronic lymphocytic leukemia expressing the kinase, ZAP-70. " 05/01/2009 - "[Clinical significance of ZAP-70 protein expression in chronic lymphocytic leukemia/small lymphocytic lymphoma]." 01/01/2008 - "ZAP-70 protein expression and CD38 positivity in B-cell chronic lymphocytic leukemia."
2.	Disease Progression 10/29/2009 - "In this study we also found that IGHV unmutated, high expression of ZAP-70 protein, and low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion, whereas in those harboring trisomy 12 only high expression of the miR-181a, among the analyzed parameters, suggested more aggressive disease. " 12/01/2007 - "In particular, the absence of somatic mutations in the immunoglobulin variable region genes and expression of the protein tyrosine kinase ZAP-70 are strongly associated with an aggressive clinical course, and both features have been correlated with a greater capacity of the BCR to transmit antigen-induced signals. "
3.	Trisomy (Trisomies) 10/29/2009 - "In this study we also found that IGHV unmutated, high expression of ZAP-70 protein, and low expression of the miR-223, miR-29c, miR-29b, and miR-181 family were strongly associated with disease progression in CLL cases harboring 17p deletion, whereas in those harboring trisomy 12 only high expression of the miR-181a, among the analyzed parameters, suggested more aggressive disease. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/2010 - "New prognostic factors such as IgVh mutational status, ZAP-70 protein expression and cytogenetic abnormalities have shown to offer important prognostic information for patients with chronic lymphocytic leukemia (CLL). " 12/01/2009 - "The factors included: age at diagnosis, gender, direct antiglobulin test (DAT), immunoglobulin heavy chain variable gene (IgHV) mutational status, ZAP-70 protein, CD38 expression level, and molecular cytogenetic aberrations were analyzed in MBL and CLL subgroups. " 07/01/2009 - "The parameters analyzed included sex, age, Binet stages, absolute lymphocyte count (ALC), immunoglobulin heavy-chain variable region (IgVH) gene mutation status, ZAP-70 protein, CD38 expression and cytogenetic aberrations. " 06/01/2012 - "The expression of ZAP-70 mRNA was significantly associated with Binet stage (P < 0.001), lactate dehydrogenase (P = 0.003), ZAP-70 protein (P = 0.018), IGHV mutational status (P = 0.038), and cytogenetic abnormality of del(17p13) or del(11q22.3) (P = 0.037) in CLL patients. "
5.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 08/15/2002 - "Mutations in the ZAP-70 protein tyrosine kinase gene result in a severe combined immunodeficiency (SCID) characterized by a selective inability to produce CD8(+) T cells and a signal transduction defect in peripheral CD4(+) cells. "

Related Drugs and Biologics

1.	Immunoglobulin Heavy Chains (Immunoglobulin Heavy Chain)
2.	Monoclonal Antibodies
3.	mouse MIRN29 microRNA
4.	Immunoglobulin Variable Region
5.	Glycogen Synthase Kinases
6.	Messenger RNA (mRNA)
7.	T-Cell Antigen Receptors (T-Cell Receptor)
8.	Protein-Tyrosine Kinases (Tyrosine Kinase)
9.	Phosphotransferases (Kinase)
10.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)