Microphthalmia-Associated Transcription Factor

A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.

Also Known As:

Networked: 476 relevant articles (1 outcomes, 32 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fisher, David E: 22 articles (01/2019 - 03/2002)
2.	Goding, Colin R: 13 articles (01/2022 - 12/2006)
3.	Bertolotto, Corine: 12 articles (01/2022 - 07/2005)
4.	Ballotti, Robert: 10 articles (01/2021 - 07/2005)
5.	Widlund, Hans R: 7 articles (01/2021 - 09/2002)
6.	Levy, Carmit: 7 articles (01/2019 - 12/2003)
7.	Davidson, Irwin: 7 articles (11/2017 - 10/2008)
8.	Razin, Ehud: 6 articles (01/2022 - 09/2002)
9.	Ballotti, R: 6 articles (11/2017 - 10/2000)
10.	Wellbrock, Claudia: 6 articles (01/2017 - 11/2003)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 01/01/2022 - "Studies on in vitro melanoma cell lines link the microphthalmia-associated transcription factor (MITF) with the regulation of the PD-L1 expression. " 03/01/2015 - "The aim of this study was to compare four such markers, namely microphthalmia transcription factor (MITF), P75, P53, and Ki-67 in malignant melanomas originating from the oral cavity and head and neck skin. " 01/01/2014 - "Compounds selected in the present study differentially altered the expression of melanocyte/melanoma specific microphthalmia-associated transcription factor (MITF) and proto-oncogene c-MYC. " 01/01/2013 - "Recent studies show that Microphthalmia Transcription Factor (MITF) has high sensitivity (88-100%) and specificity for metastatic melanoma. " 11/14/2023 - "Microphthalmia-associated transcription factor (MITF) plays pivotal roles in melanocyte development, function, and melanoma pathogenesis. "
2.	Neoplasms (Cancer) 01/01/2021 - "The histology of the main tumor was compatible with t(6:11) type microphthalmia-associated transcription factor (MiT) family translocation RCC. " 11/01/2019 - "Tumor cells for both cases were immunopositive for smooth muscle actin, microphthalmia-associated transcription factor, and cluster of differentiation 10. " 08/01/2017 - "This aggressiveness appears to be due to the cancer cells' ability to reversibly switch between phenotypes with non-invasive and invasive potential, and microphthalmia-associated transcription factor (MITF) is known to play a central role in this process. " 11/21/2016 - "Immunohistochemistry revealed that these tumor cells were positive for microphthalmia-transcription factor, S100, and CD1a but negative for HMB45, indicating that the tumor was a CCST. " 07/01/2016 - "The six tumors were assayed in parallel with and in comparison to RCC with typical morphologic or immunohistochemical features for a specific subtype (clear cell, clear cell papillary, and microphthalmia transcription factor (MiT) family translocation RCC). "
3.	Renal Cell Carcinoma (Grawitz Tumor) 04/25/2023 - "MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. " 01/01/2021 - "Microphthalmia-associated transcription factor (MiT) family aberration-associated renal cell carcinoma (MiTF-RCC) is a subtype of renal cell carcinoma harboring recurrent chromosomal rearrangements involving TFE3 or TFEB genes. " 01/01/2021 - "Clinical and Molecular Characterization of Microphthalmia-associated Transcription Factor (MITF)-related Renal Cell Carcinoma." 01/01/2021 - "6p21 translocation renal cell carcinoma (RCC) was newly classified in the WHO 2016 classification as a subtype of microphthalmia-associated transcription factor (MIT) family translocation RCC.A 42-year-old man was referred to our hospital with an asymptomatic solid mass in the right kidney identified during routine medical checkup. " 03/01/2019 - "The renal cell carcinomas associated with Xp11 translocations (Xp11 translocation RCCs) harbor gene fusions involving TFE3, a member of the microphthalmia-associated transcription factor (MiTF) family. "
4.	Angiomyolipoma 11/01/2022 - "Epithelioid angiomyolipoma is a rare variant of angiomyolipoma and a part of the microphthalmia transcription factor (MiTF) tumors. " 02/01/2018 - "Renal angiomyolipoma (AML) and perivascular epithelioid cell tumour (PEComa) are members of the microphthalmia-associated transcription factor (MiTF) family of tumours. " 01/01/2002 - "Melanoma markers, especially the new microphthalmia transcription factor (mitf), have not been previously compared in hepatic and renal angiomyolipomas. " 03/01/2001 - "Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas." 01/01/2001 - "The most recently developed melanocytic markers, microphthalmia transcription factor and tyrosinase, have not been studied in the diagnosis of angiomyolipoma. "
5.	Perivascular Epithelioid Cell Neoplasms 06/01/2002 - "Histologic examination showed the classic features of CCMMT, and immunohistochemical studies confirmed co-expression of smooth muscle actin, HMB-45, and microphthalmia transcription factor." 12/20/2016 - "Additionally, perivascular epithelioid cell tumors should not be diagnosed only based on its immunoreactivity for the microphthalmia transcription factor." 02/01/2018 - "Renal angiomyolipoma (AML) and perivascular epithelioid cell tumour (PEComa) are members of the microphthalmia-associated transcription factor (MiTF) family of tumours. " 01/01/2014 - "Recent studies have demonstrated that cathepsin K seems to be a powerful marker in identifying the microphthalmia associated transcription factor (MITF) family tumors such as renal perivascular epithelioid cell neoplasms (PEComas), alveolar soft part sarcoma, and translocation-associated renal cell carcinomas. " 04/01/2007 - "Four cases of malignant PEComas were stained with smooth muscle actin, muscle specific actin, desmin, human melanoma black-45, melan-A, microphthalmia transcription factor, S100 and cyclin D1. "

Related Drugs and Biologics

1.	Monophenol Monooxygenase (Tyrosinase)
2.	Proteins (Proteins, Gene)
3.	MART-1 Antigen
4.	dopachrome isomerase
5.	Melanins (Melanin)
6.	S100 Proteins (S 100 Protein)
7.	Type 1 Melanocortin Receptor
8.	Pro-Opiomelanocortin (Proopiomelanocortin)
9.	Small Interfering RNA (siRNA)
10.	Endothelin-3 (Endothelin 3)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Chemoradiotherapy
4.	Phototherapy (Light Therapy)
5.	Lasers (Laser)