Proto-Oncogene Proteins c-mdm2

An E3 UBIQUITIN LIGASE that interacts with and inhibits TUMOR SUPPRESSOR PROTEIN P53. Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF.

Also Known As:

Double Minute 2 Protein; MDMX Protein; Mdm-2 Protein; Murine Double Minute 2 Protein; Mdm 2 Protein; Proto Oncogene Proteins c mdm2; Proto-Oncogene Protein, c-mdm2; c mdm2 Proto Oncogene Protein; c-mdm2, Proto-Oncogene Proteins; Mdm2 Protein; c-mdm2 Proto-Oncogene Protein

Networked: 283 relevant articles (1 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Ruiwen: 4 articles (01/2018 - 09/2005)
2.	Patil, Sachin P: 4 articles (02/2015 - 12/2013)
3.	Gu, Lubing: 3 articles (01/2021 - 05/2002)
4.	Zhou, Muxiang: 3 articles (01/2021 - 05/2002)
5.	Wang, Wei: 3 articles (01/2018 - 09/2012)
6.	Wang, Hui: 3 articles (02/2015 - 09/2005)
7.	Li, Wei: 2 articles (01/2021 - 01/2015)
8.	Liu, Tao: 2 articles (01/2021 - 03/2015)
9.	Wang, Bo: 2 articles (12/2019 - 08/2019)
10.	Sasano, Hironobu: 2 articles (01/2019 - 08/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/27/2023 - "Many cancers overproduce MDM2 protein to interrupt p53 functions. " 01/01/2023 - "Comparative Dynamic Features of Apo and Bound MDM2 Protein Reveal the Mechanism of Inhibitor Recognition for Anti-Cancer Activity." 08/01/2021 - "Murine double minute 2 (MDM2) protein is the major negative regulator of p53, and genetic polymorphisms in this gene have shown to be associated with several types of cancer. " 01/01/2021 - "We demonstrate that 14 maintains its mode of action by dual targeting of MDM2 and XIAP through inducing MDM2 protein degradation and inhibiting XIAP mRNA translation, respectively, which resulted in cancer cell growth inhibition and cell death. " 01/01/2020 - "The mouse double minute 2 (MDM2) protein acts as a negative regulator of the p53 tumor suppressor. "
2.	Carcinogenesis 08/07/2017 - "Recent studies have shown that the negative regulation of p53 by the murine double minute 2 (MDM2) protein in human cells interrupts the p53 apoptotic pathway and causes tumorigenesis. " 01/01/2001 - "Nevertheless, the high prevalence of MDM2 protein overexpression found in this study suggest that MDM2 may also participate in the carcinogenesis of AQ chewing-associated oral SCCs in Taiwan." 10/01/2012 - "The murine double minute 2 protein (MDM2) and TP53 interact in regulating cell cycle, DNA repair and apoptosis process, which is crucial in carcinogenesis. " 03/01/2012 - "Herein we describe how alternative splicing of mdm2 may result in Mdm2 protein products that alter signal transduction to promote tumorigenesis. " 09/01/1998 - "In conclusion, it appears that functional inactivation of wild-type p53 by MDM2 protein overexpression plays no role in (early) gastric carcinogenesis."
3.	Breast Neoplasms (Breast Cancer) 01/01/2006 - "The present study was performed to evaluate the relationship between MDM2 protein expression and survival in breast carcinoma. " 11/01/1998 - "In this study the expression of mdm2 protein has been investigated in a series of 54 human breast carcinomas using immunoblotting methods. " 01/01/2008 - "MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk." 01/01/2006 - "MDM2 protein expression is a negative prognostic marker in breast carcinoma." 07/01/1996 - "It is suggested that altered MDM2 protein expression might be involved in the promotion of angiogenesis in human breast cancer."
4.	Carcinoma (Carcinomatosis) 01/01/1998 - "The present study represents a continuation of previous works in which we observed that lung carcinomas co-expressing MDM2 protein and p53 mutants (mt p53) exhibited more aggressive behaviour. " 07/01/2011 - "A similar pattern of expression of mdm2 protein was found in type I (36.84%, 7/19), type II (38.46%, 10/26) and type III (23.08%, 3/13) IM and gastric carcinoma (53.33%, 16/30). " 05/01/2002 - "An MDM2 antisense approach to reduce MDM2 protein levels has been successfully applied on several carcinomas in vitro and used on a few in vivo cases. " 06/01/2000 - "Mdm2 amplification was determined in 43 gastric carcinomas, and the genetic results were correlated with mdm2 protein expression, p53 alterations, and clinicopathologic data. " 03/01/1999 - "The coexistence of Mdm2 protein and p53 aberration in a subset of pulmonary carcinomas may be indicative of a gain of function phenotype with more aggressive characteristic."
5.	Glioma (Gliomas) 05/01/2007 - "Immunohistochemical study of glioma tissues showed that the G/G genotype was associated with higher expression of MDM2 protein compared to the T/T genotype, suggesting that SNP309 attenuates MDM2 protein expression in vivo. " 01/01/2019 - "In glioma cells, AEG-1 could directly interact with Murine Double Minute-2 (MDM2) protein resulting in MDM2-p53-mediated cell proliferation and apoptosis. " 08/01/2011 - "The overexpression of MDM-2 protein was an early event in malignant transformation of glioma. " 08/01/1998 - "Gliomas that overexpress wild-type p53 also express high levels of mdm2 protein and exhibit a radiosensitivity that is intermediate between normal cells and cells with mutant p53. " 05/01/2007 - "In our study population, SNP309 affected MDM2 protein level, but had no significant involvement in glioma tumorigenesis."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tumor Suppressor Protein p53
3.	Antibodies
4.	RNA (Ribonucleic Acid)
5.	Tumor Suppressor Protein p14ARF (p14ARF)
6.	Messenger RNA (mRNA)
7.	Ubiquitin
8.	Proteasome Endopeptidase Complex (Proteasome)
9.	DNA (Deoxyribonucleic Acid)
10.	Cyclin-Dependent Kinase Inhibitor p16

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy