|1.||Safe, Stephen: 33 articles (09/2015 - 03/2007)|
|2.||Jutooru, Indira: 15 articles (07/2014 - 07/2008)|
|3.||Chadalapaka, Gayathri: 13 articles (07/2014 - 07/2008)|
|4.||Abdelrahim, Maen: 8 articles (10/2014 - 05/2009)|
|5.||Sreevalsan, Sandeep: 7 articles (10/2014 - 08/2010)|
|6.||Basha, Riyaz: 7 articles (10/2014 - 07/2011)|
|7.||Chintharlapalli, Sudhakar: 7 articles (09/2012 - 03/2007)|
|8.||Lei, Ping: 7 articles (07/2012 - 05/2009)|
|9.||Pathi, Satya: 6 articles (07/2014 - 01/2011)|
|10.||Sankpal, Umesh T: 5 articles (06/2014 - 07/2011)|
|1.||Pancreatic Neoplasms (Pancreatic Cancer)
01/01/2012 - "Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy."
08/01/2010 - "RNA interference studies indicate that these repressed genes are regulated by specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4, and Western blot analysis of lysates from pancreatic cancer cells treated with CDDO and CDDO-Me shows for the first time that both compounds decreased the expression of Sp1, Sp3, and Sp4. "
07/01/2014 - "Knockdown of Sp1 alone by RNA interference also induced apoptosis and decreased pancreatic cancer cell growth and invasion, indicating that downregulation of Sp transcription factors is an important common mechanism of action for PEITC and other ROS-inducing anticancer agents. "
12/01/2013 - "Several metformin-induced responses and genes are similar to those observed after knockdown of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 by RNA interference, and we hypothesized that the mechanism of action of metformin in pancreatic cancer cells was due, in part, to downregulation of Sp transcription factors. "
10/03/2014 - "A recent study showed that metformin down-regulated specificity protein (Sp) transcription factors (TFs) Sp1, Sp3, and Sp4 in pancreatic cancer cells and tumors, and this was accompanied by down-regulation of several pro-oncogenic Sp-regulated genes. "
01/01/2015 - "Specificity protein (Sp) transcription factors play pivotal roles in maintaining the phenotypes of many cancers. "
01/01/2014 - "Specificity protein (Sp) transcription factors are overexpressed in cancer cells and regulate genes required for cell proliferation, survival and angiogenesis. "
01/01/2013 - "Specificity protein (Sp) transcription factors are overexpressed in colon and other cancers and regulate genes required for cell proliferation survival and angiogenesis. "
07/01/2011 - "Evidence is presented for the notion that Sp transcription factors may act in concert with Akt to regulate the abnormal metabolism of cancer cells."
07/01/2011 - "Role of sp transcription factors in the regulation of cancer cell metabolism."
|3.||Colonic Neoplasms (Colon Cancer)
09/01/2013 - "Mechanisms involving the curcuminoids effects in decreasing the prooncogenic specificity protein (Sp) transcription factors, and Sp-regulated genes in SW-480 colon cancer cells and how the multidrug resistance protein (MDR1) inhibition is mediated by Sp suppression. "
01/01/2015 - "Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors."
01/01/2011 - "Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells."
02/01/2014 - "These results now extend the number of NSAIDs that may have clinical potential for colon cancer chemotherapy and show that the anticancer activity of TA is due, in part, to targeting Sp transcription factors."
02/01/2011 - "Results of previous RNA interference studies in this laboratory has shown that these genes are regulated, in part, by specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 that are overexpressed in colon and other cancer cell lines and not surprisingly, GT-094 also decreased Sp1, Sp3, and Sp4 in colon cancer cells. "
|4.||Breast Neoplasms (Breast Cancer)
02/23/2012 - "Overexpression of ZBTB4 or restoration of ZBTB4 by using an antagomir inhibit growth and invasion of breast cancer cells, and this effect is due, in part, to ZBTB4-dependent repression of the specificity protein 1 (Sp1), Sp3 and Sp4 genes, and subsequent downregulation of several Sp-dependent oncogenes, in part, through competition between ZBTB4 and Sp transcription factors for GC-rich promoter sequences. "
11/15/2007 - "The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells."
01/01/2009 - "Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies."
07/01/2012 - "Treatment of ErbB2-overexpressing BT474 and MDA-MB-453 breast cancer cells with 1 to 10 μmol/L betulinic acid inhibited cell growth, induced apoptosis, downregulated specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4, and decreased expression of ErbB2. "
10/01/2007 - "Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells."
|5.||Prostatic Neoplasms (Prostate Cancer)
09/01/2012 - "CDODA-Me induces ZBTB4 in prostate cancer cells through disruption of miR-ZBTB4 interactions, and this results in downregulation of pro-oncogenic Sp transcription factors and Sp-regulated genes."
09/01/2012 - "Androgen-insensitive DU145 and PC3 human prostate cancer cells express high levels of specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4, and treatment of cells with methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate (CDODA-Me) inhibited cell growth and downregulated Sp1, Sp3, and Sp4 expression. "
01/01/2012 - "Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer."
03/15/2007 - "Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors."
01/01/2011 - "Previous studies show that BA induces proteasome-dependent degradation of specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 in prostate cancer cells and this study focused on the mechanism of action of BA in colon cancer cells. "
|5.||Proteins (Proteins, Gene)
|7.||Proteasome Endopeptidase Complex (Proteasome)
|9.||L-Lactate Dehydrogenase (Lactate Dehydrogenase)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)