Activating Transcription Factor 6

One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.
Also Known As:
ATF6 Transcription Factor; Transcription Factor, ATF6
Networked: 27 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Haromy, Alois: 2 articles (01/2013 - 06/2011)
2. Dromparis, Peter: 2 articles (01/2013 - 06/2011)
3. Sutendra, Gopinath: 2 articles (01/2013 - 06/2011)
4. Michelakis, Evangelos D: 2 articles (01/2013 - 06/2011)
5. Thuerauf, Donna J: 2 articles (08/2012 - 05/2012)
6. Glembotski, Christopher C: 2 articles (08/2012 - 05/2012)
7. Belmont, Peter J: 2 articles (08/2012 - 05/2012)
8. Ding, Zhiming: 1 article (08/2015)
9. Yang, Hai-Wei: 1 article (08/2015)
10. Ding, Qiang: 1 article (08/2015)

Related Diseases

1. Anoxia (Hypoxia)
2. Melanoma (Melanoma, Malignant)
3. Neoplasms (Cancer)
04/01/2011 - "After 24 h of Ad-IFNα infection, the KU7 cancer cells produced spliced X-box binding protein 1 and activating transcription factor 6 protein (ATF6), evoking an ER stress response that could contribute to Ad-IFNα induced apoptosis in these cancer cells. "
01/01/2013 - "ER stress signaling in the pulmonary circulation involves the activation of activating transcription factor 6, which, via induction of the reticulin protein Nogo, can lead to the disruption of the functional ER-mitochondria unit and the increasingly recognized cancer-like metabolic shift in pulmonary arterial hypertension that promotes proliferation and apoptosis resistance in the pulmonary artery wall. "
08/01/2015 - "The sex determining region Y (SRY)-box 5 (Sox5), runt-related transcription factor 3 (RUNX3), CCAAT displacement protein 1 (CUTL1), v-rel avian reticuloendotheliosis viral oncogene homolog (Rel)A, peroxisome proliferator-activated receptor γ isoform 2 (PPARγ2) and activating transcription factor 6 (ATF6) regulatory transcription factor binding sites were identified in the upstream (promoter) region of the RNPC1 gene, and may thus be involved in the effects of RNPC1 in tumors."
05/27/2014 - "Significantly, by mass spectrometry methods, we found strong biological signatures of apoptosis directly in the postchemotherapy plasma, including numerous caspase-cleaved peptides as well as relevant peptides from apoptotic and cell-stress proteins second mitochondria-derived activator of caspases, HtrA serine peptidase 2, and activating transcription factor 6. We also treated hematologic cancer cell lines with clinically relevant chemotherapeutics and monitored proteolytic fragments released into the media. "
4. Ischemia
5. Infection

Related Drugs and Biologics

1. Luciferases
2. Calcium
3. tauroursodeoxycholic acid
4. Inositol (Myoinositol)
5. Messenger RNA (mRNA)
6. Phosphotransferases (Kinase)
7. Carrier Proteins (Binding Protein)
8. Toll-Like Receptors (Toll-Like Receptor)
9. JNK Mitogen-Activated Protein Kinases
10. Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1. Warm Ischemia
2. Castration