Activating Transcription Factor 4

An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.

Also Known As:

Networked: 227 relevant articles (2 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adams, Christopher M: 8 articles (01/2022 - 04/2010)
2.	Ebert, Scott M: 7 articles (01/2022 - 04/2010)
3.	Bullard, Steven A: 4 articles (01/2020 - 08/2012)
4.	Dierdorff, Jason M: 4 articles (01/2020 - 08/2012)
5.	Miyazaki, Makoto: 4 articles (11/2018 - 08/2012)
6.	Miyazaki-Anzai, Shinobu: 4 articles (11/2018 - 08/2012)
7.	Liu, Bin: 4 articles (01/2018 - 07/2013)
8.	Dyle, Michael C: 4 articles (05/2017 - 08/2012)
9.	Bongers, Kale S: 4 articles (10/2015 - 04/2010)
10.	Fox, Daniel K: 4 articles (10/2015 - 04/2010)

Related Diseases

1.	Inflammation (Inflammations) 11/15/2021 - "Downregulation of activating transcription factor 4 attenuates lysophosphatidycholine-induced inflammation via the NF-κB pathway." 09/01/2012 - "This study aimed to dissect the role and signalling pathways of activating transcription factor 4 (ATF4) in ER-stress-associated endothelial inflammation and diabetic retinopathy. " 09/01/2012 - "Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes." 01/31/2020 - "Exercise preconditioning improved cardiac inflammation (interleukin-6, tumor necrosis factor α) and cardiac dysfunction (ejection fraction, fraction shortening) in C57 mice induced by LPS and also decreased the expression levels of GCN2, phosphorylation of eukaryotic translation initiation factor 2α (p-eIF2α), and activating transcription factor 4 (ATF4). " 01/01/2019 - "Hepatic mRNA levels of selected markers of inflammation such as haptoglobin, tumor necrosis factor α (TNF-α), IL-1β, IL-6, cluster of differentiation 68 (CD68), fibroblast growth factor 21 (FGF-21), NF-κB, activating transcription factor 4 (ATF4) were quantified by RT-qPCR. "
2.	Sepsis (Septicemia) 11/05/2022 - "Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation." 06/01/2023 - "In addition, the therapeutic efficacy of inhibiting activating transcription factor 4 (ATF4) in sepsis and sepsis-induced acute liver dysfunction was explored. "
3.	Liver Diseases (Liver Disease) 06/01/2023 - "In addition, the therapeutic efficacy of inhibiting activating transcription factor 4 (ATF4) in sepsis and sepsis-induced acute liver dysfunction was explored. "
4.	Neoplasms (Cancer) 08/18/2023 - "Activating transcription factor 4 (ATF4), a master regulator of cellular stress, is exploited by cancer cells to survive. " 01/01/2023 - "Mechanistically, circTDRD3 exerted a tumor-promoting effect by regulating the miR-891b/ITGA2 axis and AKT signaling pathway in a positive feedback manner mediated by the transcription factor ATF4. " 01/01/2022 - "Here we show that most human ccRCC tumors exhibit activation of the transcription factor ATF4. " 01/01/2021 - "In cancer cells, the transcription factor ATF4 was induced by all three tested conditions. " 02/21/2019 - "It is well known that activating transcription factor 4 (ATF4) expression is closely associated with progression of many cancers. "
5.	Diabetic Retinopathy (Retinopathy, Diabetic) 02/01/2012 - "The purpose of this study is to examine the role of endoplasmic reticulum (ER) stress and the signaling pathway of ER stress-induced activating transcription factor 4 (ATF4) in the regulation of Müller cell-derived inflammatory mediators in diabetic retinopathy. " 09/01/2012 - "This study aimed to dissect the role and signalling pathways of activating transcription factor 4 (ATF4) in ER-stress-associated endothelial inflammation and diabetic retinopathy. " 09/01/2017 - "TPL2 (Therapeutic Targeting Tumor Progression Locus-2)/ATF4 (Activating Transcription Factor-4)/SDF1α (Chemokine Stromal Cell-Derived Factor-α) Axis Suppresses Diabetic Retinopathy." 01/01/2017 - "Elevated Activating Transcription Factor 4 and Glucose-Regulated 78 Kda Protein Levels Correlate with Inflammatory Cytokines in the Aqueous Humor and Vitreous of Proliferative Diabetic Retinopathy." 09/01/2017 - "Mechanistic studies in primary human umbilical vein endothelial cells and primary retinal microvascular endothelial cells from streptozotocin-diabetic rats, db/db mice, and samples from patients with diabetic retinopathy revealed a positive parallel correlation between Nε-(carboxymethyl)lysine and the TPL2/chemokine SDF1α (stromal cell-derived factor-α) axis that is dependent on endoplasmic reticulum stress-related molecules, especially ATF4 (activating transcription factor-4). "

Related Drugs and Biologics

1.	Peptide Initiation Factors (Initiation Factor)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-6 (Interleukin 6)
4.	Phosphotransferases (Kinase)
5.	Protein Kinases (Protein Kinase)
6.	Proteins (Proteins, Gene)
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Chemokines
9.	Transcription Factor CHOP
10.	X-Box Binding Protein 1

Related Therapies and Procedures

1.	Negative-Pressure Wound Therapy
2.	Electroacupuncture
3.	Therapeutics
4.	Radiotherapy
5.	Denervation