Recoverin

A neuronal calcium-sensor protein that is found in ROD PHOTORECEPTORS and CONE PHOTORECEPTORS. It interacts with G-PROTEIN-COUPLED RECEPTOR KINASE 1 in a Ca2+ dependent manner and plays an important role in PHOTOTRANSDUCTION.

Also Known As:

Networked: 157 relevant articles (6 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ohguro, Hiroshi: 14 articles (01/2017 - 01/2002)
2.	Philippov, Pavel P: 10 articles (07/2016 - 09/2003)
3.	Adamus, Grazyna: 10 articles (05/2016 - 03/2002)
4.	Bazhin, Alexandr V: 9 articles (07/2016 - 09/2003)
5.	Nakazawa, Mitsuru: 7 articles (09/2020 - 01/2002)
6.	Saito, Wataru: 4 articles (04/2017 - 11/2005)
7.	Eichmüller, Stefan B: 4 articles (02/2012 - 01/2007)
8.	Savchenko, Marina S: 4 articles (02/2012 - 09/2003)
9.	Ohguro, Ikuyo: 4 articles (01/2010 - 08/2003)
10.	Maeda, Akiko: 4 articles (08/2006 - 07/2002)

Related Diseases

1.	Ocular Paraneoplastic Syndromes 08/01/2019 - "Recoverin antibody seemed to be specifically present in the serum of patients with cancer-associated retinopathy. " 01/01/2002 - "Pathological roles of recoverin in cancer-associated retinopathy." 08/01/1998 - "Cancer-associated retinopathy vs recoverin-associated retinopathy." 08/01/1998 - "A cellular immune response against recoverin was found only in the patient with the condition resembling cancer-associated retinopathy. " 01/01/1993 - "Chromosomal assignment of the recoverin gene and cancer-associated retinopathy."
2.	Uveitis 04/01/2001 - "These findings of the uveitopathogenic sites in recoverin may lead to improved understanding of the pathogenesis of uveitis and the means to design specific treatment." 10/01/2017 - "Patients with noninfectious uveitis have increased frequency of ARA positivity against recoverin. " 10/01/2017 - "However, ARA positivity for recoverin was more frequently observed in patients with uveitis (p = 0.002). " 10/01/2017 - "A total of 10 patients in the uveitis cohort had birdshot chorioretinopathy, and all 10 were positive for anti-recoverin ARAs. " 08/01/1998 - "Elevated levels of antibody against recoverin were found in this patient and in one of the three patients with a retinal degeneration, but in none of the eight patients with uveitis. "
3.	Carcinoma (Carcinomatosis) 01/15/1999 - "This cell culture system will be useful for investigating environments and factors which participate in the expression of the recoverin gene, and may identify regulatory features of the recoverin gene which cause it to be illicitly expressed in small-cell lung carcinomas in cancer-associated retinopathy (CAR)." 03/01/2004 - "Recently we reported that aberrant expression of recoverin was identified in more than 50% of tumor cells and their cell lines from several kinds of cancers, including gastric cancer, lung carcinoma, and other cancers. " 10/01/2001 - "As for lung cancer, the majority of CAR cases mediated by anti-recoverin autoantibodies have been revealed in patients with the most malignant lung cancer, small cell lung carcinoma (SCLC), and only one similar case has been described for a patient with non-small lung carcinoma. " 10/01/2001 - "Only several CAR patients with a few kinds of cancer (endothelial carcinoma, breast cancer, epithelial ovarian carcinoma) have so far been found to contain autoantibodies against recoverin in their sera. " 01/16/2014 - "Immunoblot analyses using the patient's serum detected autoantibodies against recoverin, CRMP-5, and α-enolase, but not carbonic anhydrase II. Neuroretinitis once resolved after almost remission of carcinoma on imaging but it recurred following the recurrence of carcinoma. "
4.	Adenocarcinoma of Lung 04/01/2000 - "Lung adenocarcinoma A549 cells, which did not express recoverin, exhibited a significant reduction in cell proliferation upon transfection with human recoverin cDNA. " 01/01/2023 - "To elucidate the currently unknown molecular mechanisms responsible for the aberrant expression of recoverin (Rec) within cancerous cells, we examined two-dimensional (2D) and three-dimensional (3D) cultures of Rec-negative lung adenocarcinoma A549 cells which had been transfected with a plasmid containing human recoverin cDNA (A549 Rec) or an empty plasmid as a mock control (A549 MOCK). " 03/01/2001 - "The effects of recoverin on calcium-dependent protein phosphorylation were studied using the A549 lung adenocarcinoma cell line, which does not express recoverin. " 01/01/2010 - "In the presence of several anti-cancer drugs, including anti-tumor antibiotics, plant alkaloids and anti-metabolites, cytotoxicity assay was performed using recoverin-positive or recoverin-negative A549 cells originating from human lung adenocarcinoma. " 04/01/2000 - "To elucidate the initial step of the molecular pathology of CAR, we examined the expression of recoverin and hsc 70 by reverse transcription-PCR and Western blot using cell lines of several kinds of cancers, including lung small cell carcinoma, lung adenocarcinoma, gastric cancer, pancreatic cancer, breast cancer, uterine cervical cancer, endometrial cancer, and leukemia. "
5.	Encephalitis (Encephalitis, Rasmussen) 01/01/2022 - "Another paraneoplastic antibody known as anti-recoverin antibodies (Abs) is also associated with basal ganglia encephalitis. " 12/01/2021 - "Autoimmune basal ganglia encephalitis associated with anti-recoverin antibodies: A case report." 12/01/2021 - "Here, we report a case of autoimmune basal ganglia encephalitis without retinal lesions or malignancy harboring anti-recoverin antibodies. " 12/01/2021 - "Based on the clinical and imaging findings, the patient was diagnosed with autoimmune basal ganglia encephalitis with anti-recoverin antibodies and administered high-dose immunoglobulins (HD-IVIG), which led to an improvement in clinical symptoms. " 12/01/2021 - "Clinicians should be aware of the possibility of autoimmune basal ganglia encephalitis showing anti-recoverin antibodies but no CAR syndrome or malignancy, which should be treated with HD-IVIG therapy."

Related Drugs and Biologics

1.	Antibodies
2.	Autoantibodies
3.	Phosphopyruvate Hydratase (Enolase)
4.	Carbonic Anhydrase II
5.	Complementary DNA (cDNA)
6.	Peptides (Polypeptides)
7.	CTLA-4 Antigen
8.	Intravenous Immunoglobulins (IVIG)
9.	Immunoglobulins (Immunoglobulin)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Injections
2.	Immunotherapy
3.	Therapeutics
4.	Plasma Exchange
5.	Drug Therapy (Chemotherapy)