Neurocalcin

A neuronal calcium sensor protein that is expressed as several isoforms and can interact with ACTIN; TUBULIN; and CLATHRIN.

Also Known As:

Hippocalcin-Like Protein 3; Neurocalcin alpha; Neurocalcin delta; Visinin-Like 1 Protein; Visinin-Like Protein; Hippocalcin Like Protein 3; Visinin Like 1 Protein; Visinin Like Protein

Networked: 45 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Intracellular Calcium-Sensing Proteins
      - Neuronal Calcium-Sensor Proteins: 4
        Neurocalcin: 45
        human HPCAL1 protein
        human NCALD protein
        human VSNL1 protein
        mouse Ncald protein
        mouse Vsnl1 protein
        rat NVP2 protein
        rat Vsnl1 protein

Experts

1.	Fagan, Anne M: 5 articles (01/2021 - 08/2011)
2.	Ladenson, Jack H: 5 articles (01/2019 - 09/2006)
3.	Xiong, Chengjie: 4 articles (01/2021 - 08/2011)
4.	Henson, Rachel L: 3 articles (01/2021 - 01/2019)
5.	Holtzman, David M: 3 articles (01/2019 - 08/2011)
6.	Lee, Jin-Moo: 3 articles (08/2011 - 09/2006)
7.	Braunewell, Karl-Heinz: 3 articles (05/2011 - 10/2008)
8.	Bateman, Randall J: 2 articles (01/2021 - 01/2019)
9.	Chhatwal, Jasmeer P: 2 articles (01/2021 - 01/2019)
10.	Christian, Bradley T: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Stroke (Strokes) 09/01/2011 - "Visinin like protein 1 (VILIP-1) is a newly discovered CNS-abundant protein which has shown promise in experimental studies, for early stroke diagnosis. " 03/16/2013 - "Blood concentrations of neuronal markers (neuron-specific enolase, visinin-like protein 1, heart type fatty acid binding protein (hFABP) and neuroglobin), astroglial markers (S100B and glial fibrillary acidic protein), inflammatory markers (IL-6, TNF-α, and C-reactive protein), blood-brain barrier marker (matrix metalloproteinase 9), and haemostatic markers (D-dimer and PAI-1) were measured within 24 hours after stroke onset. "
2.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 01/01/2017 - "Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis." 01/01/2019 - "Neurocalcin delta (NCALD) is a brain-enriched neuronal calcium sensor and its reduction acts protective against spinal muscular atrophy (SMA). "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2017 - ""Visinin-like protein-1" and "alzheimer`s disease" were employed to search "PubMed", "Springer" and "Medline" databases until July 2016 and standard mean difference (Std.MD) was calculated. " 05/01/2009 - "Some notes on visinin-like protein 1 and Alzheimer disease." 02/01/2016 - "Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration." 11/22/2022 - "Visinin-like protein 1 (VILIP-1) belongs to the group of emerging biomarkers with the potential to support the early diagnosis of Alzheimer's disease (AD). " 01/01/2020 - "Cerebrospinal fluid (CSF) visinin-like protein 1 (VILIP-1) has been suggested as a biomarker for neuron injury, which has been shown to have a important diagnostic value in symptomatic Alzheimer's disease (AD). "
4.	Ganglion Cysts (Ganglion) 08/13/2004 - "Neurocalcin-immunoreactive neurons in the petrosal ganglion innervate the taste bud." 01/12/2001 - "Decreased neurocalcin immunoreactivity in sympathetic and parasympathetic neurons of the major pelvic ganglion in aged rats." 03/01/1999 - "Neurocalcin labelled a few smaller neurons and many thin processes within the ganglion. " 01/12/2001 - "In the present study we have investigated the distribution of neurocalcin (NC) alpha isoform in the major pelvic ganglion. " 08/14/1992 - "Immunohistochemistry revealed the expression of neurocalcin in retinal amacrine cells and ganglion cells but not in the photoreceptor layer. "
5.	Cognitive Dysfunction 01/01/2015 - "Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease." 01/01/2015 - "The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has not been studied yet. " 01/01/2018 - "The aim of this study was to compare the efficiency of P300 and N200 potentials and reaction time (RT) with commonly used protein biomarkers measured in the cerebrospinal fluid (CSF), including amyloid β peptide (β1-42), total tau (t-tau), tau protein phosphorylated at threonine 181 (p-tau181), tau protein phosphorylated at serine 199 (p-tau199), tau protein phosphorylated at threonine 231 (p-tau231), and visinin-like protein 1 (VILIP-1) in differential diagnosis of AD in mild cognitive impairment (MCI) and AD patients. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Calcium
3.	Biomarkers (Surrogate Marker)
4.	Neurogranin
5.	Amyloid (Amyloid Fibrils)
6.	Chitinase-3-Like Protein 1
7.	Synaptosomal-Associated Protein 25
8.	Amyloid beta-Peptides
9.	Threonine (L-Threonine)
10.	alpha-Synuclein

Related Therapies and Procedures

1.	Oral Administration