Classical Pathway Complement C5 Convertase

A serine protease that cleaves multiple COMPLEMENT 5 into COMPLEMENT 5A (anaphylatoxin) and COMPLEMENT 5B in the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. It is a complex of CLASSICAL PATHWAY C3 CONVERTASE (C4b2a) with an additional COMPLEMENT C3B, or C4b2a3b.

Also Known As:

Complement C5 Convertase, Classical Pathway; C5 Convertase (C4b2a3b); Classical C5 Convertase; Classical Pathway C5 Convertase; C5 Convertase, Classical

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Immunoproteins: 43
      - Complement System Proteins: 33379
        Complement Activating Enzymes
        Complement C3-C5 Convertases: 87
        Classical Pathway Complement C3-C5 Convertases
        Classical Pathway Complement C5 Convertase: 1

Experts

1.	Andersen, Gregers R: 1 article (10/2020)
2.	Christiansen, Dorte: 1 article (10/2020)
3.	Fox, Rachel: 1 article (10/2020)
4.	Gadeberg, Trine A F: 1 article (10/2020)
5.	Hansen, Annette G: 1 article (10/2020)
6.	Hansen, Pernille: 1 article (10/2020)
7.	Jensen, Jens Magnus B: 1 article (10/2020)
8.	Jensen, Rasmus K: 1 article (10/2020)
9.	Johnson, Matthew B: 1 article (10/2020)
10.	Laursen, Nick S: 1 article (10/2020)

Related Diseases

1.	Hemolysis 10/15/2020 - "Surprisingly, although the nanobody does not affect classical pathway-mediated C3 cleavage, hC3Nb3 inhibits classical pathway-driven hemolysis, suggesting that the C-terminal domain of C3b has an important function in classical pathway C5 convertase activity. "