Protein Kinase C-alpha

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186 relevant articles (3 outcomes, 21 trials/studies) found for this Bio-Agent

Description: A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

Also Known As:

Protein Kinase C alpha; Protein Kinase C(alpha); PKC alpha Serine Threonine Kinase; Serine-Threonine Kinase, PKC-alpha; PKC-alpha Serine-Threonine Kinase

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24340

Transferases: 3170

Phosphotransferases: 14916

Phosphotransferases (Alcohol Group Acceptor)

Protein Kinases: 5282

Protein-Serine-Threonine Kinases: 668

Protein Kinase C: 4097

Protein Kinase C-alpha: 186

human PRKCA protein

mouse Prkca protein

Experts

1.	Lahn, Michael: 5 articles (01/2006 - 04/2003)
2.	Holmlund, Jon T: 4 articles (10/2005 - 04/2002)
3.	Huang, Chih-Yang: 3 articles (05/2008 - 09/2005)
4.	Sundell, Karen: 3 articles (01/2006 - 01/2004)
5.	Dorr, F Andrew: 3 articles (10/2005 - 04/2002)
6.	Noti, J D: 3 articles (12/2001 - 12/2000)
7.	Hsieh, Yih-Shou: 2 articles (07/2007 - 09/2005)
8.	Wu, Trang-Tiau: 2 articles (07/2007 - 09/2005)
9.	Liu, Jer-Yuh: 2 articles (07/2007 - 09/2005)
10.	Wen-Sheng, Wu: 2 articles (07/2006 - 01/2005)

Related Diseases

1.	Small Cell Carcinoma (Small Cell Lung Cancer) 11/01/2004 - "Expression levels of protein kinase C-alpha in non-small-cell lung cancer." 04/01/2008 - "Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells." 05/01/2002 - "LY900003 (Affinitac), an antisense inhibitor of protein kinase C-alpha, in non-small-cell lung cancer." 09/15/2004 - "A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer." 03/20/2006 - "PURPOSE: To determine whether aprinocarsen, an antisense oligonucleotide directed against protein kinase C-alpha, when added to the chemotherapy regimen of gemcitabine and cisplatin improved survival in patients with advanced non-small-cell lung cancer (NSCLC)" Get all the results and reference details, order at left...
2.	Lung Neoplasms (Lung Cancer) 05/01/1998 - "Antisense expression of protein kinase C alpha improved sensitivity to anticancer drugs in human lung cancer LTEPa-2 cells." 05/01/1998 - "AIM: To study the role of protein kinase C alpha (PKC alpha) in sensitivity to some clinical anticancer drugs in human lung cancer LTEPa-2 cells" Get all the results and reference details, order at left...
3.	Hypertriglyceridemia 10/01/1999 - "In conclusion, glycerol-fructose administration resulted in hypertriglyceridemia, hyperinsulinemia, and increased vascular sensitivity to 12,13-phorbol dibutyrate (with respect to the control group), and significantly greater expression of protein kinase C alpha and betaII (with respect to the glycerol group)." Get all the results and reference details, order at left...
4.	Hyperinsulinism (Hyperinsulinemia) 10/01/1999 - "In conclusion, glycerol-fructose administration resulted in hypertriglyceridemia, hyperinsulinemia, and increased vascular sensitivity to 12,13-phorbol dibutyrate (with respect to the control group), and significantly greater expression of protein kinase C alpha and betaII (with respect to the glycerol group)." Get all the results and reference details, order at left...
5.	Neoplasms (Cancer) 07/15/2006 - "Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice." 08/30/2005 - "We demonstrate that atRA is able to modulate the activity of protein kinase C alpha (PKCalpha), which is related to tumor development" 01/15/2004 - "BACKGROUND: It has been postulated that protein kinase C alpha (PKC-alpha) plays a pivotal role in signal transduction in tumor cancer cells" 08/01/2003 - "Altered protein kinase C-alpha (PKC-alpha) expression has been implicated in tumor promotion and carcinogenesis" 04/01/2003 - "One of the targets currently being studied as an important tumor-promoting factor is protein kinase C-alpha (PKC-alpha)" Get all the results and reference details, order at left...
74 Diseases and 186 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	aprinocarsen
2.	Cisplatin (Platino)
3.	gemcitabine
4.	Glycerol (Glycerine)
5.	Fructose
6.	ISIS 3521
7.	Messenger RNA (mRNA)
8.	Phosphotransferases (Kinase)
9.	JNK Mitogen-Activated Protein Kinases
10.	Antisense Oligonucleotides
119 Drugs and Important Bio-Agents and 118 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
1 Therapies and Procedures and 2 more articles analyzed in the Research Interface, order at left...

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