Protein Kinase C-alpha

A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

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Networked: 297 relevant articles (5 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Jer-Yuh: 10 articles (01/2017 - 09/2005)
2.	Huang, Chih-Yang: 7 articles (09/2016 - 09/2005)
3.	Lahn, Michael: 7 articles (03/2006 - 04/2003)
4.	Hwang, Jin-Ming: 4 articles (01/2017 - 04/2010)
5.	Tonetti, D A: 4 articles (10/2016 - 09/2000)
6.	Hsieh, Yi-Hsien: 4 articles (01/2015 - 02/2007)
7.	Leitges, Michael: 4 articles (07/2009 - 08/2004)
8.	Hsieh, Yih-Shou: 4 articles (02/2008 - 09/2005)
9.	Sundell, Karen: 4 articles (01/2006 - 12/2003)
10.	Holmlund, Jon T: 4 articles (10/2005 - 04/2002)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/01/2004 - "Expression levels of protein kinase C-alpha in non-small-cell lung cancer." 03/14/2023 - "Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha." 05/01/2002 - "LY900003 (Affinitac), an antisense inhibitor of protein kinase C-alpha, in non-small-cell lung cancer." 03/01/2004 - "This study was designed to investigate the relationship of expression of human telomerase reverse transcriptase mRNA (hTERT mRNA) and its regulators including c-myc, mutant p53, protein kinase C alpha (PKCalpha) with clinicopathological significance of expression of the four markers in non-small cell lung carcinoma (NSCLC). " 09/15/2004 - "A phase I/II study of LY900003, an antisense inhibitor of protein kinase C-alpha, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer."
2.	Lung Neoplasms (Lung Cancer) 05/01/1998 - "Antisense expression of protein kinase C alpha improved sensitivity to anticancer drugs in human lung cancer LTEPa-2 cells." 05/01/1998 - "To study the role of protein kinase C alpha (PKC alpha) in sensitivity to some clinical anticancer drugs in human lung cancer LTEPa-2 cells. " 06/20/2008 - "[The variation of intracellular distribution and translocation of the protein kinase C alpha among human lung cancer cell line with different metastasis potential.]." 01/01/2013 - "This investigation aims to prepare and optimize DOTAP cationic liposomes containing an antisense oligonuclotide (AsODN) against protein kinase C alpha in non-small cells lung cancer (NSCLC). " 06/20/2008 - "The aim of this study is to analyze the variation of intracellular distribution and translocation of the protein kinase C alpha among human high-metastatic large cell lung cancer cell line with different metastasis potential,in order to investigate the correlation between the lung carcinoma invasion and metastasis and the PKC isoforms. "
3.	Inflammation (Inflammations) 01/01/2021 - "In the present study, protein kinase C alpha (PRKCA) is involved in EGCG protection against LPS-induced inflammation and ALI. " 01/01/2010 - "Western blot analysis documented that N-f-5HT in concentrations of 10 and 100 µM significantly decreased PMA-induced phosphorylation of protein kinase C alpha/beta II. The results suggest that N-f-5HT represents an effective naturally occurring substance with potent effect on the oxidative burst of human neutrophils and could be further investigated for its pharmacological activity against oxidative stress in ischaemia-reperfusion, inflammation and other pathological conditions." 09/01/2003 - "Activation of cutaneous protein kinase C alpha induces keratinocyte apoptosis and intraepidermal inflammation by independent signaling pathways." 10/01/2021 - "Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. " 11/01/2018 - "Inflammation induces Epac-protein kinase C alpha and epsilon signaling in TRPV1-mediated hyperalgesia."
4.	Brain Ischemia (Cerebral Ischemia) 10/01/2015 - "[Conclusion] Our study demonstrates that early hyperbaric oxygen therapy has protective effects on brain tissue after cerebral ischemia, possibly via inhibition of tumor necrosis factor-alpha and phospho-protein kinase C-alpha. " 10/01/2015 - "[Purpose] The purpose of this study was to investigate whether early hyperbaric oxygen is useful in rats with permanent cerebral ischemia, and whether its mechanism relates to the inhibition of the tumor necrosis factor-alpha-protein kinase C-alpha pathway. "
5.	Hypertriglyceridemia 10/01/1999 - "In conclusion, glycerol-fructose administration resulted in hypertriglyceridemia, hyperinsulinemia, and increased vascular sensitivity to 12,13-phorbol dibutyrate (with respect to the control group), and significantly greater expression of protein kinase C alpha and betaII (with respect to the glycerol group)."

Related Drugs and Biologics

1.	Antisense Oligonucleotides
2.	aprinocarsen
3.	Cisplatin (Platino)
4.	Gemcitabine
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Glycerol (Glycerine)
7.	Fructose
8.	ISIS 3521
9.	Messenger RNA (mRNA)
10.	Zinc

Related Therapies and Procedures

1.	Hyperbaric Oxygenation
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Therapeutics
5.	Enzyme Replacement Therapy