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Hepatocyte Nuclear Factor 4

A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.
Also Known As:
HNF4 Transcription Factor; Hepatocyte Nuclear Factor 4-alpha; Hepatocyte Nuclear Factor 4-beta; Hepatocyte Nuclear Factor 4-gamma; Hepatocyte Nuclear Factor-Forkhead Homolog 4; Nuclear Receptor Subfamily 2 Group A, Member 2; Nuclear Receptor Subfamily 2, Group A, Member 1; Hepatocyte Nuclear Factor 4 alpha; Hepatocyte Nuclear Factor 4 beta; Hepatocyte Nuclear Factor 4 gamma; Hepatocyte Nuclear Factor Forkhead Homolog 4; Transcription Factor, HNF4
Networked: 115 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sladek, Frances M: 4 articles (11/2019 - 01/2009)
2. Li, Dan: 3 articles (01/2022 - 04/2015)
3. Tong, Qiangsong: 3 articles (01/2022 - 04/2015)
4. Zheng, Liduan: 3 articles (01/2022 - 04/2015)
5. McCarthy, Mark I: 3 articles (01/2018 - 06/2012)
6. Wang, Jian: 2 articles (10/2022 - 12/2004)
7. Apte, Udayan: 2 articles (01/2022 - 06/2013)
8. Gunewardena, Sumedha: 2 articles (01/2022 - 06/2013)
9. Song, Huajie: 2 articles (01/2022 - 06/2015)
10. Walesky, Chad: 2 articles (01/2022 - 06/2013)

Related Diseases

1. Non-alcoholic Fatty Liver Disease
01/01/2020 - "Mechanistic experiments revealed that VDR interacted with hepatocyte nuclear factor 4 α (HNF4α) and that overexpression of HNF4α improved HFD-induced NAFLD and metabolic abnormalities in liver-specific VDR-knockout mice. "
11/01/2019 - "IR, present in the NAFLD-PCOS association could decrease the hepatic production of sex hormone-binding globulin through a possible regulation mediated by hepatocyte nuclear factor 4 alpha. "
01/01/2018 - "To further explore the relationship between SHBG and NAFLD, mRNA expression of SHBG and hepatocyte nuclear factor 4-α (HNF4α), as well as intrahepatic triglycerides, were determined from the liver tissues of 32 subjects with different degrees of steatosis. "
01/01/2019 - "The present study was undertaken to investigate the modulatory effects of dietary supplementation fisetin on hepatocyte nuclear factor 4 α (HNF4α) gene expression, hepatic lipin-1 signaling, thioredoxin-interacting protein (TXNIP) levels, poly-(ADP-ribose)-polymerase-1 (PARP-1) activity, as well as some oxidative stress parameters in a rat model of high-fat/high-sucrose (HFHS) induced NAFLD. "
11/01/2019 - "Several crucial transcription factors that play a central role in regulating these lipid metabolism genes during NAFLD, including peroxisome proliferator-activated receptor gamma (PPARγ), sterol regulatory element-binding transcription factor 1 (SREBF1), carbohydrate-responsive element-binding protein, and hepatocyte nuclear factor 4 alpha, were also found to be modulated by EGFR. "
2. Acute-Phase Reaction
3. Type 2 Diabetes Mellitus (MODY)
4. Metabolic Syndrome (Dysmetabolic Syndrome X)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Transcription Factors (Transcription Factor)
2. Protein Isoforms (Isoforms)
3. Lipopolysaccharides
4. Endotoxins
5. Glucokinase
6. Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)
7. Proteins (Proteins, Gene)
8. Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)
9. Warfarin (Coumadin)
10. Thioredoxins

Related Therapies and Procedures

1. Transplantation
2. Fat-Restricted Diet (Diet, Fat Restricted)