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Neonatal Hyperbilirubinemia

Accumulation of BILIRUBIN, a breakdown product of HEME PROTEINS, in the BLOOD during the first weeks of life. This may lead to NEONATAL JAUNDICE. The excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. The condition may be self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) or pathological with toxic levels of bilirubin.
Also Known As:
Hyperbilirubinemia, Neonatal; Direct Hyperbilirubinemia, Neonatal; Hyperbilirubinemia During Infancy; Indirect Hyperbilirubinemia, Neonatal; During Infancies, Hyperbilirubinemia; Hyperbilirubinemia, Neonatal Direct; Hyperbilirubinemia, Neonatal Indirect; Infancy, Hyperbilirubinemia During; Neonatal Direct Hyperbilirubinemia; Neonatal Indirect Hyperbilirubinemia
Networked: 691 relevant articles (38 outcomes, 84 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hyperthermia
2. Hypoglycemia (Reactive Hypoglycemia)
3. Pre-Eclampsia (Preeclampsia)
4. Brain Injuries (Brain Injury)
5. Shoulder Dystocia

Experts

1. Stevenson, David K: 12 articles (01/2019 - 08/2004)
2. Kaplan, Michael: 11 articles (01/2018 - 01/2004)
3. Wong, Ronald J: 10 articles (01/2019 - 08/2004)
4. Hammerman, Cathy: 10 articles (06/2016 - 01/2004)
5. Kusaka, Takashi: 9 articles (01/2021 - 12/2004)
6. Tukey, Robert H: 9 articles (01/2021 - 10/2013)
7. Vreman, Hendrik J: 8 articles (01/2022 - 08/2004)
8. Itoh, Susumu: 8 articles (01/2021 - 12/2004)
9. Tiribelli, Claudio: 8 articles (01/2021 - 01/2016)
10. Ebbesen, Finn: 6 articles (01/2022 - 09/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neonatal Hyperbilirubinemia:
1. BilirubinIBA
2. MetalloporphyrinsIBA
3. AgarIBA
4. ClofibrateFDA Link
5. Phenobarbital (Luminal)FDA Link
6. Glucose (Dextrose)FDA LinkGeneric
7. Oxidoreductases (Dehydrogenase)IBA
8. ZincIBA
9. Charcoal (Charbon)IBA
10. Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA

Therapies and Procedures

1. Phototherapy (Light Therapy)
2. Massage (Zone Therapy)
3. Therapeutics
4. Length of Stay
5. Cesarean Section (Caesarean Section)
01/01/2023 - "The risk of caesarean section (pooled OR = 0.32; 95%CI: 0.22 to 0.46), small-for-gestational age (SGA) neonates (pooled OR = 0.40; 95%CI: 0.19 to 0.84), preterm delivery (pooled OR = 0.07; 95%CI: 0.06 to 0.09), respiratory morbidity (pooled OR = 0.26; 95%CI: 0.19 to 0.37), neonatal hyperbilirubinemia (pooled OR = 0.19; 95%CI: 0.10 to 0.40), and NICU admission (pooled OR = 0.18; 95%CI: 0.14 to 0.25) was significantly lower in singleton pregnancies with GDM than in twin pregnancies with GDM. "
11/01/2011 - "EA and SA at cesarean section seem to be better among the four anesthesia techniques considering neonatal hyperbilirubinemia. "
06/01/2013 - "Large for gestational age (LGA) newborn, infant's stay in the neonatal intensive care unit (NICU) >24 h, neonatal hyperbilirubinemia and cesarean section due to cephalopelvic disproportion were identified as specific GDM adverse outcomes. "
09/01/2011 - "Treating mild GDM is cost-effective in terms of improving maternal and neonatal outcomes including decreased rates of preeclampsia, cesarean sections, macrosomia, shoulder dystocia, permanent and transient brachial plexus injury, neonatal hypoglycemia, neonatal hyperbilirubinemia, and neonatal intensive care unit admissions."
01/01/2020 - "The abnormal umbilical artery Doppler waveform is associated with cesarean section delivery, neonatal intensive care unit admission, respiratory distress syndrome, neonatal sepsis, neonatal hyperbilirubinemia, and early neonatal death compared to normal umbilical artery Doppler flow."