Heme Oxygenase-1

A ubiquitous stress-responsive enzyme that catalyzes the oxidative cleavage of HEME to yield IRON; CARBON MONOXIDE; and BILIVERDIN.

Also Known As:

Hemeoxygenase 1; Heme Oxygenase 1; Oxygenase-1, Heme

Networked: 3159 relevant articles (180 outcomes, 321 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Heme Oxygenase (Decyclizing): 1069
        Heme Oxygenase-1: 3159
        PEP-1-heme oxygenase-1 fusion protein: 9
        Heme Oxygenase 1 Deficiency: 1
        human HMOX1 protein
        mouse Hmox1 protein
        zebrafish heme oxygenase 1

Experts

1.	Agarwal, Anupam: 29 articles (12/2021 - 02/2003)
2.	Abraham, Nader G: 25 articles (01/2021 - 01/2002)
3.	Dulak, Jozef: 23 articles (12/2020 - 04/2002)
4.	Fang, Qin: 22 articles (02/2022 - 06/2011)
5.	Wang, Jishi: 22 articles (02/2022 - 01/2014)
6.	Jozkowicz, Alicja: 22 articles (12/2020 - 01/2006)
7.	Pol, Olga: 21 articles (01/2022 - 01/2012)
8.	Otterbein, Leo E: 20 articles (04/2016 - 07/2003)
9.	Schipper, Hyman M: 18 articles (01/2021 - 02/2006)
10.	Ma, Dan: 18 articles (01/2020 - 08/2012)

Related Diseases

1.	Reperfusion Injury 01/01/2018 - "Reply to: "Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non parenchymal cells?"" 01/01/2018 - "Protective effects of heme oxygenase 1 during ischemia-reperfusion injury: Hepatocytes or non-parenchymal cells?" 01/01/2015 - "Intestinal ischemic preconditioning ameliorates hepatic ischemia/reperfusion injury in rats: role of heme oxygenase 1 in the second window of protection." 08/05/2010 - "Local heme oxygenase-1 overexpression in the graft ameliorates the ischaemic reperfusion injury. " 12/01/2007 - "Heme oxygenase-1 ameliorates ischemia/reperfusion injury by targeting dendritic cell maturation and migration."
2.	Inflammation (Inflammations) 01/01/2015 - "PPARγ/Heme oxygenase-1 (HO-1) signaling was proved effective in suppressing both apoptosis and inflammation. " 12/01/2021 - "Our in vitro study confirmed that PAH inhibited microglial activation by activating the nuclear factor-E2-related factor 2/heme oxygenase-1 pathway, exhibited by alleviated inflammation and oxidative stress. " 07/14/2015 - "Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model." 05/01/2003 - "An increasing number of studies implicate heme oxygenase-1 (HO-1) in the regulation of inflammation. " 10/01/2023 - "Correction To: Increased expression of heme oxygenase-1 suppresses airway branching morphogenesis in fetal mouse lungs exposed to inflammation."
3.	Ischemia 01/01/2013 - "HbG200-mediated preinduction of heme oxygenase-1 improves bile flow and ameliorates pericentral downregulation of Bsep and Mrp2 following experimental liver ischemia and reperfusion." 06/01/2004 - "To study the change and role of heme oxygenase-1 (HO-1) in injured lungs following limb ischemia/reperfusion in rats. " 02/05/2002 - "In the present study, we used recombinant adeno-associated virus (rAAV) as a vector for direct delivery of the cytoprotective gene heme oxygenase-1 (HO-1) into the rat myocardium, with the purpose of evaluating this strategy as a therapeutic approach for long-term protection from ischemia-induced myocardial injury. " 01/01/2021 - "Heme Oxygenase-1 in Macrophages Impairs the Perfusion Recovery After Hindlimb Ischemia by Suppressing Autolysosome-Dependent Degradation of NLRP3." 01/01/2019 - "Background and aims: Diabetic kidney is more sensitive to ischemia/reperfusion (I/R) injury, which is associated with increased oxidative stress and impaired nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. "
4.	Hypoxia (Hypoxemia) 01/01/2018 - "R-SLNs administration resulted in significant reduction in hypoxia-inducible factor 1α (HIF-1α) levels, whereas, nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase 1 (HO-1) levels were increased after R-SLNs treatment. " 01/01/2021 - "Nuclear heme oxygenase-1 improved the hypoxia-mediated dysfunction of blood-spinal cord barrier via the miR-181c-5p/SOX5 signaling pathway." 10/04/2005 - "Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector." 08/17/2023 - "Furthermore, increased expression of hypoxia inducible factor 1α (HIF1α) and heme oxygenase 1 (HO1) was observed in db/db mice and HG/HF-treated HK-2 cells as well. " 07/06/2023 - "Furthermore, we found that hypoxia-inducible factor-1α (HIF-1α)/heme oxygenase 1 (HMOX1) pathway was responsible for the impacts of P300 on ferroptosis of HASMCs. "
5.	Wounds and Injuries (Trauma) 01/01/2009 - "Heme oxygenase-1 (HO-1) is known to be induced by oxidative stress and to confer protection against oxidative tissue injuries. " 08/01/2004 - "Heme oxygenase-1 (HO-1) is induced by oxidative stress and is thought to confer protection against oxidative tissue injuries. " 01/01/2016 - "The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. " 01/01/2022 - "Heme oxygenase-1 (HO-1) has been reported to play an important role against renal injuries. " 02/17/2017 - "Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair."

Related Drugs and Biologics

1.	Enzymes
2.	Proteins (Proteins, Gene)
3.	Heme (Haem)
4.	Antioxidants
5.	NF-kappa B (NF-kB)
6.	Messenger RNA (mRNA)
7.	Superoxide Dismutase
8.	quinone (benzoquinone)
9.	Glutathione (Reduced Glutathione)
10.	Heat-Shock Proteins (Heat-Shock Protein)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Splenectomy
3.	Therapeutics
4.	Ligation
5.	Transplantation