Hepatocyte Nuclear Factor 1-beta

A hepatocyte nuclear factor that is closely related to HEPATOCYTE NUCLEAR FACTOR 1-ALPHA but is only weakly expressed in the LIVER. Mutations in hepatocyte nuclear factor 1-beta are associated with renal CYSTS and MATURITY-ONSET DIABETES MELLITUS type 5.

Also Known As:

HNF-1beta; Hepatocyte Nuclear Factor-1beta; Liver Specific Transcription Factor LF-B3; Variant Hepatic Nuclear Factor 1; HNF 1beta; Hepatocyte Nuclear Factor 1 beta; Hepatocyte Nuclear Factor 1beta; Liver Specific Transcription Factor LF B3

Networked: 129 relevant articles (0 outcomes, 17 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Hattersley, Andrew T: 11 articles (07/2009 - 10/2001)
2.	Bingham, Coralie: 10 articles (07/2008 - 10/2001)
3.	Ellard, Sian: 9 articles (07/2008 - 10/2001)
4.	Igarashi, Peter: 8 articles (01/2010 - 10/2002)
5.	Bellanné-Chantelot, Christine: 7 articles (10/2010 - 04/2004)
6.	Hiesberger, Thomas: 7 articles (01/2009 - 10/2002)
7.	Hattersley, A T: 7 articles (12/2006 - 01/2000)
8.	Pontoglio, Marco: 5 articles (01/2010 - 10/2002)
9.	Ellard, S: 5 articles (12/2006 - 01/2001)
10.	Pearson, Ewan R: 5 articles (07/2006 - 12/2002)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 10/01/1999 - "These studies strongly suggest that heterozygous mutations in the HNF-1beta gene are associated with a syndrome characterized by MODY and severe, non-diabetic renal disease. " 05/07/1999 - "Recent genetic studies have identified two HNF-1beta mutations, R177X and A263fsinsGG, in subjects with a monogenic form of type 2 diabetes. " 02/02/2021 - "This report is of a series of 4 cases from Poland of MODY type 5 associated with mutations in the hepatocyte nuclear factor 1 beta (HNF1B) gene, including a 13-year-old boy and adult men aged 33, 34, and 35 years. " 09/23/2020 - "The hepatocyte nuclear factor 1-beta (HNF1B) gene is responsible for MODY type 5 (MODY5), which has distinctive clinical features including renal disease. " 04/01/2009 - "Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population."
2.	Carcinoma (Carcinomatosis) 04/01/2007 - "Recent microarray studies have shown that the expression of hepatocyte nuclear factor-1beta (HNF-1beta) was significantly up-regulated in clear cell carcinoma (CCC) of the ovary. " 01/01/2018 - "HNF-1beta did not have the anticipated discriminatory power for clear cell carcinoma, nor did MUC6 or CA-IX for gastric-type carcinoma. " 01/01/2015 - "We evaluated the diagnostic value of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma. " 01/01/2015 - "Diagnostic value of dual detection of hepatocyte nuclear factor 1 beta (HNF-1β) and napsin A for diagnosing ovarian clear cell carcinoma." 12/01/2012 - "Hepatocyte nuclear factor 1-beta (HNF1β) has recently emerged as a relatively sensitive and specific marker for ovarian clear cell carcinoma. "
3.	Neoplasms (Cancer) 01/01/2021 - "Hepatocyte nuclear factor 1 beta: A perspective in cancer." 01/01/2021 - "Gene expression profiling shows upregulation of hepatocyte nuclear factor 1-beta (HNF1β) and oxidative stress-related genes, and has identified epithelial-like and mesenchymal-like tumor subgroups. " 01/01/2015 - "A review on hepatocyte nuclear factor-1beta and tumor." 01/01/2006 - "Our results indicate that HNF-1beta is an excellent molecular marker for ovarian clear cell tumors, including benign, borderline and malignant lesions. " 01/01/2006 - "In nine of the 12 cases, distinct nuclear immunostaining for HNF-1beta was detected in the endometriotic epithelium, as well as in the clear cell tumor. "
4.	Clear Cell Adenocarcinoma 07/01/2007 - "Immunohistochemical detection of hepatocyte nuclear factor 1beta in ovarian and endometrial clear-cell adenocarcinomas and nonneoplastic endometrium." 03/01/2007 - "Specific expression of hepatocyte nuclear factor-1beta in the ovarian clear cell adenocarcinoma and its application to cytological diagnosis." 07/01/2007 - "Recent studies have noted specific expression of hepatocyte nuclear factor (HNF) 1beta in ovarian clear-cell adenocarcinoma (CCA). " 03/01/2007 - "Previous studies using DNA microarrays have demonstrated that hepatocyte nuclear factor-1beta (HNF-1beta) is expressed specifically in clear cell adenocarcinoma (CCC). "
5.	Endometriosis 04/01/2009 - "Recent studies based on genome-wide expression analysis technology have noted specific expression of hepatocyte nuclear factor-1beta (HNF-1beta) in endometriosis and CCC, suggesting that early differentiation into the clear cell lineage takes place in the endometriosis. " 01/01/2006 - "HNF-1beta expression was observed either in atypical endometriosis (four cases), or in endometriosis of a reactive nature (five cases). " 11/01/2009 - "HNF-1beta is also expressed in ovarian endometriosis, which is a probable origin of clear cell carcinoma. " 06/01/2006 - "Clear-cell carcinomas are characterized by mutations of TGFbetaR2 and over-expression of HNF-1beta, and probably arise from ovarian endometriosis. " 01/01/2006 - "Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary."

Related Drugs and Biologics

1.	Hepatocyte Nuclear Factor 1-beta
2.	Transcription Factors (Transcription Factor)
3.	Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)
4.	Hepatocyte Nuclear Factors
5.	Proteins (Proteins, Gene)
6.	DNA (Deoxyribonucleic Acid)
7.	Racemases and Epimerases (Epimerases and Racemases)
8.	Biomarkers (Surrogate Marker)
9.	Progesterone Receptors (Progesterone Receptor)
10.	Estrogen Receptors

Related Therapies and Procedures

1.	Kidney Transplantation