Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)

Hepatocyte nuclear factor 1-alpha is a transcription factor found in the LIVER; PANCREAS; and KIDNEY that regulates HOMEOSTASIS of GLUCOSE.

Also Known As:

Hepatocyte Nuclear Factor 1 alpha; Albumin Proximal Factor; HNF-1alpha; Hepatocyte Nuclear Factor 1alpha; LFB1 Transcription Factor; Liver-Specific Transcription Factor LF-B1; HNF 1alpha; Liver Specific Transcription Factor LF B1

Networked: 224 relevant articles (0 outcomes, 26 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843

Experts

1.	Hattersley, Andrew T: 12 articles (02/2011 - 01/2002)
2.	Hattersley, A T: 12 articles (11/2007 - 07/2000)
3.	Ellard, Sian: 10 articles (05/2013 - 12/2002)
4.	Zucman-Rossi, Jessica: 10 articles (02/2010 - 05/2003)
5.	Ellard, S: 9 articles (11/2007 - 09/2000)
6.	Hansen, T: 9 articles (11/2007 - 03/2000)
7.	Froguel, P: 9 articles (01/2007 - 01/2000)
8.	Pedersen, O: 8 articles (11/2007 - 03/2000)
9.	Bioulac-Sage, Paulette: 6 articles (02/2010 - 11/2003)
10.	Rebouissou, Sandra: 5 articles (02/2010 - 09/2004)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 08/01/2008 - "The purpose of this study was to assess the 1,5-AG levels in patients with HNF-1alpha MODY and in type 2 diabetic subjects with a similar degree of metabolic control. " 05/01/2008 - "The aim of this study was to determine the prevalence of exocrine pancreas dysfunction in HNF-1alpha MODY patients. " 02/01/2007 - "The results of this study provide evidence that the haplotype of HNF-1alpha decreases the risk of type 2 diabetes in Chinese individuals." 01/01/2007 - "In summary, our study showed no association between HNF-1alpha mutations resulting in MODY phenotype and apoM levels. " 10/01/2001 - "The aim of our study was to determine the contribution of the HNF-1alpha gene to the development of MODY in a Polish population. "
2.	Type 3 Maturity-Onset Diabetes of the Young 01/01/2017 - "Over the past years, several studies have reported the association of missense mutations in the Hepatocyte Nuclear Factor 1 Alpha (HNF1A) with MODY3. " 12/01/2006 - "This study provides in vitro and in vivo evidence that common variants in the MODY3 gene, HNF-1alpha, influence transcriptional activity and insulin secretion in vivo. " 01/01/2018 - "Generation of an induced pluripotent stem cell (iPSC) line from a patient with maturity-onset diabetes of the young type 3 (MODY3) carrying a hepatocyte nuclear factor 1-alpha (HNF1A) mutation." 01/01/2017 - "Hepatocyte nuclear factor 1 alpha (HNF1α) defects cause Mature Onset Diabetes of the Young type 3 (MODY3), characterized by defects in beta-cell insulin secretion. " 05/01/2014 - "Gene defects in the Hepatocyte Nuclear Factor -1 alpha (HNF1a) causes MODY3. "
3.	Type 1 Maturity-Onset Diabetes of the Young 12/01/2002 - "Conditional suppression of HNF-4alpha, the MODY1 gene, showed a similar phenotype in INS-1 cells to HNF-1alpha. " 09/01/1999 - "Among 115 Scandinavian families, mutations in the HNF-1alpha gene represented the most common cause of familial early-onset ( </= 40 years) diabetes: MODY3 (5.2 %) more than MODY2 (3.5 %) more than MIDD (2.6 %) more than MODY1 (1.7 %)." 09/15/1997 - "In contrast to the glucokinase and HNF-1alpha genes, mutations in the HNF-4alpha gene are a relatively uncommon cause of MODY, and our understanding of the MODY1 form of diabetes is based on studies of only a single family, the R-W pedigree. " 02/01/2003 - "The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY. " 02/01/2003 - "We identified 20 different mutations in the HNF-4alpha, GCK and HNF-1alpha in 29 families (48% of all families studied), giving a relative prevalence of 5% of MODY1, 31% of MODY2 and 11.5% of MODY3 among the Czech kindred with MODY. "
4.	Mason-Type Diabetes 10/01/2009 - "Transgenic cloned pigs carrying a mutant human hepatocyte nuclear factor 1alpha gene, which is known to cause the type 3 form of maturity-onset diabetes of the young, were produced using a combined technology of intracytoplasmic sperm injection-mediated gene transfer and somatic cell nuclear transfer. " 03/01/2006 - "Mechanisms of mutual functional interactions between HNF-4alpha and HNF-1alpha revealed by mutations that cause maturity onset diabetes of the young." 10/01/2002 - "Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young." 11/01/2000 - "Hepatocyte nuclear factor 1 alpha (HNF-1 alpha) mutations in maturity-onset diabetes of the young." 01/01/2019 - "Genetic Study of Hepatocyte Nuclear Factor 1 Alpha Variants in Development of Early-Onset Diabetes Type 2 and Maturity-Onset Diabetes of the Young 3 in Iran."
5.	Type 2 Maturity-Onset Diabetes of the Young 04/01/2000 - "Mutations in the GCK/MODY2 and HNF-1alpha/MODY3 genes account for the majority of cases in a panel of Spanish MODY families, with MODY3 being the most frequent subtype. " 09/01/1999 - "Among 115 Scandinavian families, mutations in the HNF-1alpha gene represented the most common cause of familial early-onset ( </= 40 years) diabetes: MODY3 (5.2 %) more than MODY2 (3.5 %) more than MIDD (2.6 %) more than MODY1 (1.7 %)." 12/01/2016 - "The 39 mutation-positive samples had 1 of 39 rare variants, of which the majority were in genes encoding either glucokinase (GCK, or MODY2) or hepatocyte nuclear factor 1-alpha (HNF1A, or MODY3). " 07/01/2005 - "The most common are MODY2 and MODY3, caused by mutations in the genes encoding glucokinase and hepatocyte nuclear factor 1-alpha respectively. " 01/01/2005 - "By far MODY2 (due to mutations of the glucokinase gene) and MODY3 (due to mutations in hepatocyte nuclear factor-1alpha) are the most frequent. "

Related Drugs and Biologics

1.	Glucokinase
2.	Transcription Factors (Transcription Factor)
3.	Hepatocyte Nuclear Factors
4.	Glucose (Dextrose)
5.	Hepatocyte Nuclear Factor 1-beta
6.	Hepatocyte Nuclear Factor 4
7.	Enzymes
8.	Facilitative Glucose Transport Proteins (Glucose Transporter)
9.	CCAAT-Enhancer-Binding Protein-alpha
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Contraception (Birth Control)
2.	Glycemic Control