Type 4 Fibroblast Growth Factor Receptor

A fibroblast growth factor receptor that is mainly expressed in LUNG; KIDNEY; PANCREAS; and SPLEEN. It also plays an important role in SKELETAL MUSCLE development and can contribute to NEOPLASTIC CELL TRANSFORMATION.

Also Known As:

Receptor, Fibroblast Growth Factor, Type 4; Fibroblast Growth Factor Receptors 4; Receptor 4, Fibroblast Growth Factor; Fibroblast Growth Factor Receptor 4

Networked: 152 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Shun-Fa: 6 articles (05/2021 - 01/2015)
2.	Ullrich, Axel: 6 articles (01/2019 - 08/2006)
3.	Berger, Walter: 5 articles (01/2022 - 01/2014)
4.	Grasl-Kraupp, Bettina: 5 articles (01/2022 - 01/2014)
5.	Grusch, Michael: 5 articles (01/2022 - 01/2014)
6.	Marian, Brigitte: 5 articles (01/2022 - 01/2014)
7.	Asa, Sylvia L: 5 articles (06/2013 - 05/2003)
8.	Ezzat, Shereen: 5 articles (06/2013 - 05/2003)
9.	Ye, Yanwei: 4 articles (10/2020 - 12/2010)
10.	Zhao, Chunlin: 4 articles (10/2020 - 12/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "First-in-Human Study of INCB062079, a Fibroblast Growth Factor Receptor 4 Inhibitor, in Patients with Advanced Solid Tumors." 02/01/2021 - "Fibroblast growth factor receptor 4 (FGFR4) has been indicated as a potential "oncogene" in various types of cancer. " 01/01/2021 - "Alterations in fibroblast growth factor receptor 4 (FGFR4) were identified in 5 of 68 (7%) of tumor samples, whereas differential overexpression of FGFR4 was confirmed orthogonally using 2 platforms. " 10/30/2020 - "An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer." 05/01/2020 - "Fibroblast growth factor receptor 4 (FGFR4) expression has association with tumor malignancy. "
2.	Hepatocellular Carcinoma (Hepatoma) 07/01/2011 - "Herein we describe the development of a humanized anti- fibroblast growth factor receptor 4 (FGFR4) antibody as a potential therapeutic for hepatocellular carcinoma (HCC). " 12/01/2022 - "6-Amino-2,4,5-trimethylpyridin-3-ol and 2-amino-4,6-dimethylpyrimidin-5-ol derivatives as selective fibroblast growth factor receptor 4 inhibitors: design, synthesis, molecular docking, and anti-hepatocellular carcinoma efficacy evaluation." 01/01/2022 - "Fibroblast growth factor receptor 4 (FGFR4) has been identified as a potential target due to its transmission of the FGF19 signaling pathway, which is critical to hepatocellular carcinoma (HCC). " 01/01/2022 - "Fibroblast growth factor receptor 4 (FGFR4) has been identified as a potential target for the treatment of hepatocellular carcinoma (HCC) with aberrant FGFR4 signaling because of its important role in HCC progression and development. " 10/01/2014 - "Recently, we found upregulation of fibroblast growth factor receptor 4 (FGFR4) in a subset of hepatocellular carcinoma (HCC). "
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2018 - "This is the first study to investigate the relationships among fibroblast growth factor receptor 4 (FGFR4) genetic polymorphisms, development of uterine cervical cancer, clinicopathological variables, and patient prognosis in Taiwanese women. " 01/01/2018 - "Association of Fibroblast Growth Factor Receptor 4 Genetic Polymorphisms With the Development of Uterine Cervical Cancer and Patient Prognosis." 01/01/2018 - "Study on the Association between the Fibroblast Growth Factor Receptor 4 Expression and High-Risk Human Papillomavirus Infection in Cervical Cancer and Precancerous Lesions." 01/01/2018 - "To discuss the correlation between the expression of fibroblast growth factor receptor 4 (FGFR4) and human papillomavirus (HPV) infection in cervical cancer and precancerous lesions. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Prognostic implications of fibroblast growth factor receptor 4 polymorphisms in primary breast cancer." 09/06/2016 - "From a functional screen to identify key drivers of basal-like breast cancer cell growth, we identified fibroblast growth factor receptor 4 (FGFR4) as a potential mediator of cell survival. " 12/01/2015 - "The involvement of KL in breast cancer led us to investigate its relationship in the context of breast cancer, with one of the protagonists of its function, fibroblast growth factor receptor 4 (FGFR4). " 12/01/2010 - "Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer." 03/11/2010 - "Oncogenome screening has identified a fibroblast growth factor receptor 4 (FGFR4) Y367C mutation in the human breast cancer cell line MDA-MB453. "
5.	Colorectal Neoplasms (Colorectal Cancer) 10/25/2016 - "In colorectal cancer (CRC), fibroblast growth factor receptor 4 (FGFR4) is upregulated and acts as an oncogene. " 02/06/2014 - "Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer." 02/01/2014 - "Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer." 09/03/2019 - "Correction: Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer." 10/25/2016 - "Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer."

Related Drugs and Biologics

1.	lenvatinib
2.	Transforming Growth Factor beta (TGF-beta)
3.	Interleukin-8 (Interleukin 8)
4.	Codon (Codons)
5.	Biomarkers (Surrogate Marker)
6.	fisogatinib
7.	Calcineurin
8.	Phospholipases (Phospholipase)
9.	Fibroblast Growth Factor-23
10.	Fibroblast Growth Factors (Fibroblast Growth Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Chemoradiotherapy
4.	Drug Therapy (Chemotherapy)