|1.||Perner, Sven: 8 articles (10/2015 - 12/2010)|
|2.||Pitteloud, Nelly: 7 articles (03/2013 - 03/2005)|
|3.||Franzen, Alina: 5 articles (09/2014 - 10/2012)|
|4.||Kristiansen, Glen: 4 articles (10/2015 - 01/2013)|
|5.||Wang, Fen: 4 articles (04/2015 - 03/2002)|
|6.||Göke, Friederike: 4 articles (09/2014 - 10/2012)|
|7.||Kirsten, Robert: 4 articles (09/2014 - 10/2012)|
|8.||Boehm, Diana: 4 articles (05/2014 - 10/2012)|
|9.||Wolf, Jürgen: 4 articles (02/2014 - 12/2010)|
|10.||Quinton, Richard: 4 articles (03/2013 - 07/2006)|
11/01/2015 - "An oncogenic fibroblast growth factor receptor 1 (FGFR1) mutation (N546K) was detected, and the FGFR1 locus frequently showed copy number gain (31.7%) in primary tumors. "
09/01/2015 - "In 88% of the spontaneous tumor samples a heterogeneous FGFR1 protein expression was observed. "
07/01/2015 - "In the second cohort of specimens with known FGFR1 amplification by fluorescence in situ hybridization, 23 of 24 had adequate tumor by IHC, and 73.9% (17 of 23) were positive for FGFR1 protein expression. "
06/01/2015 - "Fibroblast growth factor receptor 1 (FGFR1) plays a critical role in many human cancers. "
05/01/2015 - "Myeloid and lymphoid neoplasms with abnormalities of fibroblast growth factor receptor 1 gene (FGFR1) are a rare and aggressive disease group that harbors translocations of FGFR1 with at least 14 recognized partner genes. "
|2.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/01/2013 - "The aim of this study was to elucidate whether fibroblast growth factor receptor 1 amplification is also a common genetic event in head and neck squamous cell carcinoma. "
02/10/2015 - "To investigate the frequency and the prognostic impact of fibroblast growth factor receptor 1 (FGFR1) gene amplification in 526 curatively resected esophageal squamous cell carcinoma (ESCC). "
02/10/2015 - "Fibroblast growth factor receptor 1 gene amplification is associated with poor survival in patients with resected esophageal squamous cell carcinoma."
06/10/2014 - "Recently, fibroblast growth factor receptor 1 (FGFR1) was discovered in squamous cell carcinomas (SCC) of the lung with FGFR1 amplification described as a promising predictive marker for anti-FGFR inhibitor treatment. "
05/01/2014 - "So far, about 40% of lung squamous cell carcinoma has been found harbouring driver oncogenes, in which fibroblast growth factor receptor 1 (FGFR1) plays important roles. "
|3.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2015 - "Fibroblast growth factor receptor 1 (FGFR1) has been reported to be overexpressed in colorectal cancer (CRC) and suggested to be a therapeutic target. "
01/01/2013 - "Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer."
08/01/2014 - "Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression."
01/01/2013 - "Resembling a potential therapeutic drug target, fibroblast growth factor receptor 1 (FGFR1) amplification and expression was assessed in 515 human colorectal cancer (CRC) tissue samples, lymph node metastases and CRC cell lines. "
01/01/2015 - "Fibroblast Growth Factor Receptor 1 Gene Copy Number and mRNA Expression in Primary Colorectal Cancer and Its Clinicopathologic Correlation."
08/01/2011 - "NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats."
08/01/2011 - "The aim of this study was to assess the impact of a selective FGFR1 tyrosine kinase inhibitor NP603 on HSC proliferation and hepatic fibrosis. "
01/01/2015 - "Fibroblast growth factor receptor 1 (FGFR1) and α5β1 integrin were extensively expressed on NCAM+ cells within the incipient IRF areas, whereas human epididymis protein-4 (HE4) was found to be present in few NCAM+ cells of both normal and interstitium with incipient fibrosis. "
|5.||Myeloproliferative Disorders (Myeloproliferative Disorder)
01/01/2015 - "The 8p11 myeloproliferative syndrome (EMS) is an aggressive chronic myeloproliferative disorder (MPD) that is caused by constitutive activation of fibroblast growth factor receptor 1. EMS is rare and, consequently, effective treatment for this disease has not been established. "
05/12/1998 - "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)."
04/01/1998 - "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP."
07/01/2007 - "The 8p11 myeloproliferative syndrome (EMS) is a chronic myeloproliferative disorder molecularly characterized by fusion of various 5' partner genes to the 3' part of the fibroblast growth factor receptor 1 (FGFR1) gene at 8p, resulting in constitutive activation of the tyrosine kinase activity contained within FGFR1. "
01/02/2004 - "The t(8;13) translocation, found in a rare and aggressive type of stem cell myeloproliferative disorder, leads to the generation of a fusion protein between the N-terminal gene product of fused in myeloproliferative disorders (FIM)/ZNF198 and the fibroblast growth factor receptor 1 (FGFR1) kinase domain. "
|1.||Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
|5.||aurora kinase (aurora A kinase)
|6.||Epidermal Growth Factor Receptor (EGF Receptor)
|7.||Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
|8.||Adenocarcinoma of lung
|9.||anaplastic lymphoma kinase
|10.||Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)
|3.||Molecular Targeted Therapy