Paxillin

Paxillin is a signal transducing adaptor protein that localizes to FOCAL ADHESIONS via its four LIM domains. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.

Networked: 487 relevant articles (2 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Salgia, Ravi: 12 articles (11/2020 - 02/2002)
2.	Jiang, Wen G: 6 articles (01/2019 - 09/2008)
3.	Furukawa, Keiko: 6 articles (08/2016 - 08/2005)
4.	Furukawa, Koichi: 6 articles (08/2016 - 08/2005)
5.	Hamamura, Kazunori: 6 articles (08/2016 - 08/2005)
6.	Ohkawa, Yuki: 5 articles (10/2022 - 03/2008)
7.	Turner, Christopher E: 5 articles (01/2022 - 02/2011)
8.	Lee, Huei: 4 articles (01/2020 - 12/2010)
9.	Wu, De-Wei: 4 articles (01/2020 - 12/2010)
10.	Hammes, Stephen R: 4 articles (11/2019 - 09/2010)

Related Diseases

1.	Neoplasms (Cancer) 10/14/2021 - "Through in vitro assays it was found that the superior MOF vector can greatly enhance cellular endocytosis and endo/lysosomal escape of sheltered plasmids, resulting in successful knock-in of GFP-tagged paxillin genomic sequences in cancer cell lines with high transfection potency compared to our previous studies. " 03/01/2003 - "In this study we evaluated the levels of paxillin and p130CAS in feline and canine mammary tumor tissues at different stages of malignancy. " 11/01/2023 - "Disrupting CCR4 or paxillin activity limited NI and dampened tumor size and tumor innervation. " 05/04/2023 - "However, increasing evidence suggests that paxillin is aberrantly expressed in many cancers. " 01/01/2022 - "In paxillin-depleted 3D tumor organoids, collective cell invasion was substantially perturbed. "
2.	Lymphatic Metastasis 01/01/2017 - "High p-paxillin expression was significantly associated with greater depth of invasion (p=0.002), lymph node metastasis (p=0.048) and poorer disease-free patient survival (log-rank test, p=0.021; Cox-regression analysis, p=0.031). " 01/01/2018 - "Conclusion Paxillin was significantly upregulated in PCa compared with BPH and normal tissues and associated with lymph node metastasis and shortened BFS of PCa. " 01/01/2018 - "The receiver operating characteristic (ROC) curve indicated that Paxillin expression (AUC=0.723) more accurately predicted PCa lymph node metastasis than Gleason score (AUC=0.692). " 01/01/2018 - "Logistic regression analysis showed that Paxillin and Gleason score were independent risk factors for PCa lymph node metastasis (P<0.05). " 01/01/2018 - "Results The association between Paxillin expression, lymph node metastasis and biochemical PCa recurrence was analyzed. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2021 - "In the present study, immunohistochemical detection showed the expression of SphK1 and paxillin was higher in human CRC tissues than those of normal colorectal mucosal tissues, they were both associated with TNM staging, lymphatic, and distance metastasis. " 01/01/2022 - "In conclusion, upregulation of miRNA-5703 inhibited pressure-induced growth and metastasis by suppressing the SRC-FAK-FOXO1 axis and SRC-paxillin axis. " 01/01/2021 - "Together, these findings reveal that SphK1-driven autophagy may promote the invasion and metastasis of CRC via promoting the expression of focal adhesion paxillin and its phosphorylation." 01/01/2021 - "So, SphK1 may promote CRC metastasis via inducing the expression of paxillin expression and its phosphorylation, in vivo. " 12/01/2019 - "The paxillin expression in our samples was scored based on the extent and intensity of immunoreactivity and compared with histological type, clinical stage, and distant metastasis. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2011 - "The purpose of the study was to investigate the expression of TOP2A, EZH2 and paxillin in relation to classic prognostic parameters and their significance as prognostic markers in imprints of resected breast carcinomas. " 08/27/2009 - "In conclusion, our studies show that PAR2 agonists facilitate breast cancer cell chemokinesis through the G(alphai)-c-Src-JNK-paxillin signaling pathway." 03/01/2007 - "In the current study, we sought to explore the relationship further between paxillin expression and clinicopathologic features and clinical outcome in breast cancer. " 11/06/2023 - "Mechanistically, we identify PXN/paxillin, a key component of the mechanotransducing machinery, as a direct binding partner and substrate of ULK1/2. ULK-mediated phosphorylation of PXN at S32 and S119 weakens homotypic interactions and liquid-liquid phase separation of PXN, impairing FA assembly, which in turn alters the mechanical properties of breast cancer cells and their response to mechanical stimuli. " 11/05/2023 - "Additionally, the non-phosphorylatable mutant of paxillin at Tyr31 reduces actin stress fiber formation, migration, and invasion of breast cancer cells. "
5.	Prostatic Neoplasms (Prostate Cancer) 08/03/2001 - "This study examined the ability of NK4, a recently discovered HGF/SF variant, to inhibit the influence of HGF/SF on cell-matrix interaction, paxillin phosphorylation, and invasion of prostate cancer cells. " 11/01/2019 - "Thus, paxillin appears to be an important transcriptional regulator in prostate cancer, and analysis of its transcriptome might lead to novel approaches toward the diagnosis and treatment of this important disease." 11/01/2019 - "Paxillin regulated genomic networks in prostate cancer." 07/01/2012 - "Accordingly, paxillin was required for normal growth of human prostate cancer cell xenografts, and its expression was elevated in human prostate cancer tissue microarrays. " 07/01/2012 - "Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Focal Adhesion Protein-Tyrosine Kinases
3.	Matrix Metalloproteinase 2 (Gelatinase A)
4.	Tyrosine (L-Tyrosine)
5.	Phosphotransferases (Kinase)
6.	Integrins
7.	Talin
8.	Crk-Associated Substrate Protein
9.	Vinculin
10.	Cadherins (E-Cadherin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Transplantation
3.	Therapeutics
4.	Lasers (Laser)
5.	Traction