|1.||Cheng, Qiao: 5 articles (01/2011 - 06/2008)|
|2.||Man, Kwan: 5 articles (01/2011 - 06/2008)|
|3.||Fan, Sheung Tat: 4 articles (01/2011 - 06/2008)|
|4.||Lo, Chung Mau: 4 articles (01/2011 - 06/2008)|
|5.||Ng, Kevin T: 3 articles (01/2011 - 06/2008)|
|6.||Sun, Chris K: 3 articles (01/2011 - 06/2008)|
|7.||Loftus, Joseph C: 3 articles (08/2009 - 03/2003)|
|8.||Sasaki, Terukatsu: 3 articles (09/2005 - 01/2002)|
|9.||Llorente-Cortés, Vicenta: 2 articles (08/2015 - 12/2013)|
|10.||Bayes-Genis, Antoni: 2 articles (08/2015 - 12/2013)|
|1.||Brain Ischemia (Cerebral Ischemia)
01/30/2004 - "N-methyl-D-aspartate receptor and L-type voltage-gated Ca2+ channel activation mediate proline-rich tyrosine kinase 2 phosphorylation during cerebral ischemia in rats."
09/18/2003 - "Two types of calcium channels regulating activation of proline-rich tyrosine kinase 2 induced by transient brain ischemia in rat hippocampus."
09/18/2003 - "In this article, brain ischemia was induced by four-vessel occlusion, and the effect of ischemia/reperfusion on proline-rich tyrosine kinase 2 (Pyk2) was studied. "
04/24/2003 - "To investigate whether the phosphorylation of p38 in cerebral ischemia occurs via angiotensin II receptor type 1a (AT1a), we examined the time course of phosphorylation of p38 and proline-rich tyrosine kinase 2 in AT1a knock-out mouse striatal neurons during middle cerebral artery occlusion (MCAO) and reperfusion. "
06/15/2015 - "Previous studies have demonstrated that activation of proline-rich tyrosine kinase 2 (PYK2) in cerebral ischemia is involved in the modulation of N-methyl-d-aspartate-type (NMDA) glutamate receptor activity and Ca(2+) dynamics, resulting in ischemic neuron death ultimately. "
09/01/2003 - "In the present study, we investigated the effects of NSCCs on the ET-1-induced proline-rich tyrosine kinase 2 (PYK2) phosphorylation in C6 glioma cells. "
05/01/2005 - "In this report, we investigated the role of proline-rich tyrosine kinase 2 (Pyk2) and FAK with regard to influencing glioma cell phenotypes. "
01/01/2014 - "Furthermore, phosphorylation of proline-rich tyrosine kinase 2 (Pyk2) participated in the mechanisms by which SOCE regulated focal adhesion turnover and epithelial-to-mesenchymal (-like) transition in glioma cells, both of which are considered to be critical for tumor progression. "
01/01/2015 - "Using western blot analysis, we found upregulation of proline rich tyrosine kinase 2 (Pyk2) protein phosphorylated at Tyr579/580 in glioma cells treated with microglia conditioned medium. "
01/01/2014 - "Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy."
|3.||Hepatocellular Carcinoma (Hepatoma)
11/01/2008 - "The aim of the current study is to elucidate the mechanism of proline-rich tyrosine kinase 2 (Pyk2)-mediated cell proliferation and invasiveness in hepatocellular carcinoma (HCC) cells. "
01/01/2011 - "Proline-rich tyrosine kinase 2 (Pyk2) promotes cell motility of hepatocellular carcinoma through induction of epithelial to mesenchymal transition."
11/01/2008 - "Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation."
01/01/2011 - "We previously demonstrated Proline rich tyrosine kinase 2 (Pyk2) plays important roles in regulating tumor progression, migration and invasion in hepatocellular carcinoma (HCC). "
12/01/2013 - "High expression of proline-rich tyrosine kinase 2 is associated with poor survival of hepatocellular carcinoma via regulating phosphatidylinositol 3-kinase/AKT pathway."
|4.||Neoplasm Metastasis (Metastasis)
04/18/2011 - "To study the influence of proline-rich tyrosine kinase 2 (Pyk2) on hepatic metastasis and microstructure of colon cancer cells in nude mice. "
10/01/2006 - "Proline-rich tyrosine kinase 2 (Pyk2) is implicated in regulating the organization of actin cytoskeleton, a process critical for cell migration, mitosis, and tumor metastasis. "
05/01/2000 - "Expression of focal adhesion kinase (p125 FAK) and proline-rich tyrosine kinase 2 (PYK2/CAKb) in cerebral metastases, correlation with VEGF-R-, ecNOS III-labelling and morphometric data."
12/01/2013 - "Western blot analysis showed that hypoxia induced a sustained phosphorylation of proline-rich tyrosine kinase 2 concomitantly with LRP1 overexpression in human VSMCs (hVSMCs). "
04/15/2015 - "In the present study, we demonstrated that proline-rich tyrosine kinase 2 (Pyk2), a nonreceptor type protein tyrosine kinase, plays a crucial role in the pathogenesis of pulmonary hypertension (PH) using an animal model of hypoxia-induced PH. Resistance to hypoxia-induced PH was markedly higher in Pyk2-deficient mice than in wild-type mice. "
08/01/2015 - "Previous work from our group showed that hypoxia upregulates the phosphorylated form of the Ca(2+)-dependent nonreceptor protein tyrosine kinase (PTK) proline-rich tyrosine kinase 2 (pPyk2) protein levels in a low-density lipoprotein receptor-related protein (LRP1)-dependent manner. "
12/01/2013 - "Deletion of LRP1 using small-interfering RNA technology or treatment of hVSMCs with the Src family kinase inhibitor PP2 impaired hypoxia-induced phosphorylation of proline-rich tyrosine kinase 2 levels. "
|2.||Focal Adhesion Kinase 2
|3.||Protein-Tyrosine Kinases (Tyrosine Kinase)
|4.||tyrosine receptor (receptor, tyrosine)
|6.||Small Interfering RNA (siRNA)
|7.||Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)
|9.||Neurotransmitter Agents (Neurotransmitter)
|10.||Glutamate Receptors (Glutamate Receptor)