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Focal Adhesion Kinase 1

A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION.
Also Known As:
Endogenous Substrate pp120; Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK; p125FAK Protein; Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK
Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Black, Jennifer O: 1 article (10/2012)
2. Halpern, Jennifer L: 1 article (10/2012)
3. Cates, Justin M M: 1 article (10/2012)
4. Whited, Brent W: 1 article (10/2012)
5. Itani, Doha M: 1 article (10/2012)
6. Homlar, Kelly C: 1 article (10/2012)
7. Keedy, Vicki L: 1 article (10/2012)
8. Hande, Kenneth R: 1 article (10/2012)
9. Schwartz, Herbert S: 1 article (10/2012)
10. Coffin, Cheryl M: 1 article (10/2012)

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