Focal Adhesion Protein-Tyrosine Kinases

A family of non-receptor, PROLINE-rich protein-tyrosine kinases.

Also Known As:

Focal Adhesion Kinase; Focal Adhesion Protein-Tyrosine Kinase; Focal Adhesion Protein Tyrosine Kinase Family; Focal Adhesion Protein Tyrosine Kinases; Focal Adhesion Protein-Tyrosine Kinase Family

Networked: 1701 relevant articles (32 outcomes, 143 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cance, William G: 52 articles (01/2022 - 01/2003)
2.	Golubovskaya, Vita M: 42 articles (12/2016 - 08/2003)
3.	Frame, Margaret C: 21 articles (07/2022 - 12/2004)
4.	Beierle, Elizabeth A: 17 articles (06/2022 - 04/2007)
5.	Guan, Jun-Lin: 16 articles (01/2020 - 02/2005)
6.	Sood, Anil K: 14 articles (05/2019 - 10/2004)
7.	Schlaepfer, David D: 12 articles (01/2022 - 03/2003)
8.	Stewart, Jerry E: 11 articles (06/2022 - 02/2005)
9.	Hochwald, Steven N: 11 articles (01/2019 - 08/2009)
10.	Pachter, Jonathan A: 10 articles (11/2022 - 05/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Previous studies have shown that LKB1 is a negative regulator of the focal adhesion kinase (FAK), but in vivo studies testing the efficacy of FAK inhibition in LKB1 mutant cancers are lacking. " 01/01/2017 - "A series of 1,3,5-triazinic inhibitors of focal adhesion kinase (FAK) has recently been shown to exert antiangiogenic activity against HUVEC cells and anticancer efficacy against several cancer cell lines. " 01/08/2015 - "A series of triazinic inhibitors of focal adhesion kinase (FAK) have been recently shown to exert antiangiogenic activity against HUVEC cells and anticancer efficacy against several cancer cell lines. " 01/01/2019 - "Phase I Study of the Focal Adhesion Kinase Inhibitor BI 853520 in Japanese and Taiwanese Patients with Advanced or Metastatic Solid Tumors." 01/01/2019 - "Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies."
2.	Colorectal Neoplasms (Colorectal Cancer) 05/19/2017 - "NTN-1 treatment preserved BBB integrity and improved neurological functions through a Deleted in Colorectal Cancer/focal adhesion kinase/RhoA signaling pathway after SAH. " 05/01/2023 - "[Neutrophil extracellular traps activates focal adhesion kinase by upregulating MMP9 expression to promote proliferation and migration of mouse colorectal cancer cells]." 01/01/2022 - "High expression of phosphorylated focal adhesion kinase predicts a poor prognosis in human colorectal cancer." 05/02/2021 - "We found that it interacts with deleted colorectal carcinoma (DCC) to activate focal adhesion kinase phosphorylation exhibiting neuroprotection. " 08/01/2014 - "Nuclear expression of phosphorylated focal adhesion kinase is associated with poor prognosis in human colorectal cancer."
3.	Neoplasm Metastasis (Metastasis) 05/01/2008 - "This study was designed to investigate the inhibitory effect of AE on the metastasis potential of HO-8910PM cell line in vitro, and the role of AE in focal adhesion kinase (FAK) expression. " 01/01/2022 - "Analysis in potentially novel microfluidic-derived microtissues and in vivo demonstrates decreased extrusion and invasion following focal adhesion kinase (FAK) inhibition, consistent with decreased metastasis. " 10/18/2021 - "Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. " 10/01/2014 - "Here, our data demonstrate, contrary to established dogma, that loss of haematopoietic-derived focal adhesion kinase (FAK) is sufficient to enhance tumour metastasis. " 10/01/2014 - "Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis."
4.	Carcinoma (Carcinomatosis) 01/13/2022 - "The purpose of this study was to examine the clinical significance of metabolic genes and focal adhesion kinase (FAK) activity in advanced ovarian high-grade serous carcinoma (HGSC). " 01/01/2018 - "Focal adhesion kinase (FAK) is associated with poor prognosis in urinary bladder carcinoma." 01/01/2016 - "Recently, the number of reports on focal adhesion kinase (FAK) as a vital therapeutic target in solid carcinomas has increased; however, the prognostic role of FAK status remains poorly understood. " 01/01/2016 - "Prognostic Value of Focal Adhesion Kinase (FAK) in Human Solid Carcinomas: A Meta-Analysis." 12/15/2014 - "It forms a complex with both focal adhesion kinase (FAK, also known as PTK2) and Src in SCC cells derived from skin carcinomas induced by administration of the chemical DMBA followed by TPA (the DMBA/TPA model). "
5.	Melanoma (Melanoma, Malignant) 12/01/2022 - "Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma." 01/01/2020 - "SERINE-910 Phosphorylated Focal Adhesion Kinase Expression Predicts Better Overall and Disease-free Survival in Melanoma." 06/01/2019 - "We found that focal adhesion kinase (FAK) and AKT signaling pathways, implicated in the regulation of cell migration and invasion, were up-regulated in melanoma CSCs. " 01/01/2016 - "In addition, our data suggested that enhancement of melanoma migration by U2AF2-dependent CD44v8-10 splicing is mediated by Src/focal adhesion kinase/RhoA activation and formation of stress fibers, as well as CD44-E-selectin binding reinforcement. " 06/28/2014 - "RUNX2 knockdown in melanoma cell lines significantly decreased Focal Adhesion Kinase expression, and inhibited their cell growth, migration and invasion ability. "

Related Drugs and Biologics

1.	TAE226
2.	Integrins
3.	Proteins (Proteins, Gene)
4.	Mitogen-Activated Protein Kinases
5.	Vinculin
6.	Phosphotransferases (Kinase)
7.	Paxillin
8.	Small Interfering RNA (siRNA)
9.	Matrix Metalloproteinase 2 (Gelatinase A)
10.	Mitogen-Activated Protein Kinase Kinases (MEKs)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Radiotherapy
5.	Neoadjuvant Therapy