Aquaporin 5

Aquaporin 5 is a water-specific channel protein that is expressed primarily in alveolar, tracheal, and upper bronchial EPITHELIUM. It plays an important role in maintaining water HOMEOSTASIS in the LUNGS and may also regulate release of SALIVA and TEARS in the SALIVARY GLANDS and the LACRIMAL GLAND.

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Networked: 201 relevant articles (2 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adamzik, Michael: 8 articles (01/2021 - 04/2011)
2.	Soveral, Graça: 6 articles (12/2022 - 04/2016)
3.	Kwon, Tae-Hwan: 6 articles (05/2022 - 01/2011)
4.	Rahmel, Tim: 6 articles (01/2021 - 01/2018)
5.	Rump, Katharina: 6 articles (01/2021 - 04/2013)
6.	Nejsum, Lene N: 5 articles (05/2022 - 10/2016)
7.	Nowak, Hartmuth: 5 articles (01/2021 - 01/2018)
8.	Peters, Jürgen: 5 articles (01/2020 - 04/2011)
9.	Siffert, Winfried: 5 articles (01/2020 - 04/2011)
10.	Login, Frédéric H: 4 articles (05/2022 - 10/2016)

Related Diseases

1.	Lung Injury 08/01/2006 - "To explore the expression and the modulation of aquaporin 5(AQP5) in hyperoxia induced lung injury. " 08/01/2006 - "[Expression and modulation of aquaporin 5 in hyperoxia induced lung injury]." 01/01/2020 - "Given that the mechanism involved in hypoxia-induced lung injury is different from that of ventilator-induced lung injury, we examined the effects of thyroid function on lung extravascular fluid (LF), aquaporin 5 (AQP 5) expression, and alveolar viscoelasticity (AVE) in mechanically ventilated rat. " 06/04/2019 - "Fasudil alleviates LPS-induced lung injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs." 01/01/2013 - "Immunofluorescence analysis revealed co-localization of pro-SP-c and α-smooth muscle actin in the alveoli after a single dose of 12 Gy. These data suggest that, i] the FVB/N mouse strain is sensitive to thoracic radiation ii] aquaporin-5, E-cadherin, and pro-SP-c may serve as sensitive indicators of radiation-induced lung injury; and iii] the epithelial-to-mesenchymal transition may play an important role in the development of radiation-induced lung fibrosis."
2.	Kwashiorkor 04/01/2019 - "Switching to normal diet reverses kwashiorkor-induced salivary impairments via increased nitric oxide level and expression of aquaporin 5 in the submandibular glands of male Wistar rats." 04/01/2019 - "RKG showed improved salivary function evidenced by reduced salivary lag-time and potassium and increased flow rate, sodium, amylase, IgA secretion rate, leptin, submandibular nitric oxide level, and aquaporin 5 expression compared with KG. This study for the first time demonstrated that kwashiorkor caused significant reduction in salivary secretion through reduction of nitric oxide level and aquaporin 5 expression in submandibular salivary glands. "
3.	Neoplasms (Cancer) 05/01/2017 - "Previous studies described that the expression of aquaporin 5 (AQP5) was altered in tumors of various organs. " 10/07/2022 - "The expression of aquaporin-5 was restored in tumor-bearing mice injected with DMA before irradiation. " 04/01/2021 - "Deciphering the structure, function, expression and regulation of aquaporin-5 in cancer evolution." 10/01/2016 - "This review aims to highlight the current knowledge and hypothesis regarding downstream signaling partners of aquaporin-5 in relation to cancer cell migration. " 10/01/2016 - "The role of aquaporin-5 in cancer cell migration: A potential active participant."
4.	Edema (Dropsy) 01/01/2007 - "Expression of the keratin-12 and aquaporin-5 genes was downregulated, consistent with the Klf4CN corneal epithelial fragility and stromal edema, respectively. " 06/04/2019 - "Our results suggest that fasudil could restore the expression of aquaporin 5 to eliminate LPS-induced lung edema and prevent LPS-induced pulmonary inflammation by blocking the inflammatory pathway. " 01/01/2013 - "At the periphery and even inside the extensive areas of edema and intraalveolar hemorrhage, enlarged, apparently hypertrophic type I pneumocytes (PI) were detected and interpreted as a non-specific attempt of clearence of the intraalveolar fluid, in which ionic transport, particularly of sodium, plays a predominant role, as suggested by the apparently increased ENaC and aquaporin 5 expression. " 06/01/2001 - "Aquaporin 5 (AQP5), the major water channel expressed in alveolar, tracheal, and upper bronchial epithelium, is significantly down-regulated during pulmonary inflammation and edema. " 01/01/2019 - "Our study aimed to determine whether the altered expression of biomarkers linked to corneal injuries, such as the edema-regulating proteins aquaporin-1 and aquaporin-5 (AQP1 and AQP5), occurred following primary blast exposure. "
5.	Infections 01/01/2000 - "Immunoblotting studies demonstrated significantly reduced levels of AQP1 and AQP5 protein after infection as well. " 10/01/2021 - "Activation of Aquaporin 5 by carcinogenic Helicobacter pylori infection promotes epithelial-mesenchymal transition via the MEK/ERK pathway." 08/01/1997 - "This study compared the localization of the alpha(v)beta3/5 integrins in the different cell types of the rat submandibular gland with the susceptibility of these cells to infection by an intraductally administered replication-deficient recombinant type 5 adenovirus coding for rat aquaporin 5 (termed AdrAQP5). " 11/01/2020 - "Via effects on serum/glucocorticoid-regulated kinase 1 (SGK1) signaling, aldosterone, tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor (VEGF), aquaporin 5 (AQP5) and/or Na+/K+-ATPase, chronic sub-optimal hydration in the weeks before exposure to COVID-19 may conceivably result in: greater abundance of angiotensin converting enzyme 2 (ACE2) receptors in the lung, which increases likelihood of COVID-19 infection, lung epithelial cells which are pre-set for exaggerated immune response, increased capacity for capillary leakage of fluid into the airway space, and/or reduced capacity for both passive and active transport of fluid out of the airways. "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Sodium
3.	Amylases
4.	Leptin
5.	Potassium
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Immunoglobulin A (IgA)
8.	lipoxin A4
9.	Proteins (Proteins, Gene)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Low-Level Light Therapy (LLLT)
2.	Therapeutics
3.	Resuscitation
4.	Ligation