Aquaporin 1

Aquaporin 1 forms a water-specific channel that is constitutively expressed at the PLASMA MEMBRANE of ERYTHROCYTES and KIDNEY TUBULES, PROXIMAL. It provides these cells with a high permeability to WATER. In humans polymorphisms of this protein result in the Colton blood group antigen.

Also Known As:

Networked: 241 relevant articles (3 outcomes, 43 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cai, Li: 4 articles (01/2021 - 04/2018)
2.	Li, Rong: 4 articles (01/2021 - 04/2018)
3.	Griggs, Kim: 4 articles (11/2017 - 06/2012)
4.	Klebe, Sonja: 4 articles (11/2017 - 06/2012)
5.	Li, Xue-Jun: 4 articles (05/2012 - 08/2002)
6.	Basaldella, Luca: 4 articles (07/2010 - 01/2006)
7.	Longatti, Pierluigi: 4 articles (07/2010 - 01/2006)
8.	Chen, Rui: 3 articles (01/2022 - 01/2012)
9.	Gros, Stephanie J: 3 articles (01/2021 - 12/2017)
10.	Mu, Yu-Rong: 3 articles (01/2021 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2017 - "Vasculogenic mimicry (VM) is a newly described phenomenon associated with increased aggressiveness in other malignancies, and has been characterized in MM. Normal mesothelium expresses aquaporin 1 (AQP1) and retained expression has been associated with improved survival in MM. AQP1 is expressed by normal vascular endothelium and is involved in mediating MM cell motility and proliferation. " 11/23/2023 - "Author's Reply: "Aquaporin 1 in cancer: Oncogene or a tumor suppressor?"" 11/02/2023 - "Aquaporin 1 in cancer: Oncogene or a tumor suppressor?" 01/29/2017 - "Role of Aquaporin 1 Signalling in Cancer Development and Progression." 01/01/2017 - "Increasing evidences showed that aquaporin 1 played a role in tumor prognosis and diagnosis. "
2.	Inflammation (Inflammations) 09/01/2018 - "The aim of this study was to determine the therapeutic efficacy of ZO against VCM-induced oxidative stress, inflammation, apoptosis and kidney aquaporin 1 (AQP1) levels in rats. " 01/01/2021 - "Vascular Inflammation Is Associated with Loss of Aquaporin 1 Expression on Endothelial Cells and Increased Fluid Leakage in SARS-CoV-2 Infected Golden Syrian Hamsters." 04/01/2018 - "Previous studies have shown that aquaporin 1 (AQP1) is up-regulated in synovium and cartilage of rheumatoid arthritis (RA) patients and that AQP1 may be involved in joint swelling and synovial inflammation. " 11/21/2023 - "Moreover, we identified the aquaporin 1 (AQP1) and protein kinase A (PKA) pathway as critical regulators of inflammation and apoptosis. " 05/01/2018 - "Cytoprotective effect of aquaporin 1 against lipopolysaccharide-induced apoptosis and inflammation of renal epithelial HK-2 cells."
3.	Biliary Atresia 01/01/2022 - "When treated with EGF+FGF2, biliary atresia organoids expressed differentiation (cytokeratin 7 and hepatocyte nuclear factor 1 homeobox B) and functional (somatostatin receptor 2, cystic fibrosis transmembrane conductance regulator [CFTR], aquaporin 1) markers, restored polarity with improved localization of F-actin, β-catenin and ZO-1, increased CFTR function, and decreased uptake of R123. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "Many genes are associated with the occurrence and prognosis of WT. This study aimed to explore the key genes and potential molecular mechanisms through bioinformatics and to verify the effects of aquaporin 1 (AQP1) on WT metastasis. " 01/01/2012 - "In this study, we were going to elucidate the involvement of aquaporin 1 and 4 (AQP1,4) in the metastasis of lung cancer. " 01/01/2023 - "Identification of key genes and validation of key gene aquaporin 1 on Wilms' tumor metastasis." 01/01/2017 - "The expression level of aquaporin 1 protein significantly correlated with tumor-node-metastasis stage ( P = .002) and overall survival time ( P = .010). " 07/01/2016 - "Aquaporin 1 (AQP1) overexpression has been shown to be associated with uncontrolled cell replication, invasion, migration, and tumor metastasis. "
5.	Rheumatoid Arthritis 01/01/2021 - "Previous studies have confirmed the pathologic role of synovial aquaporin 1 (AQP1) in rheumatoid arthritis (RA), but its associations with the abnormal biologic behaviors of fibroblast-like synoviocytes (FLS) remain unclear. " 01/01/2020 - "Previous studies have confirmed that aquaporin 1 (AQP1) is up-regulated in synovium of rheumatoid arthritis (RA), but its exact pathogenic mechanisms in RA are unclear. " 04/01/2018 - "Previous studies have shown that aquaporin 1 (AQP1) is up-regulated in synovium and cartilage of rheumatoid arthritis (RA) patients and that AQP1 may be involved in joint swelling and synovial inflammation. " 01/01/2021 - "Lentivirus-Mediated Overexpression or Silencing of Aquaporin 1 Affects the Proliferation, Migration and Invasion of TNF-α-Stimulated Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Wnt/β-Catenin Signaling Pathway." 11/01/2013 - "To observe the effect of acetazolamide (AZ) on the expressions of aquaporin 1 (AQP1) and AQP3 in fibroblast-like synoviocytes of rheumatoid arthritis (RAFLSs) and explore the roles of AQP1 and AQP3 in the development of rheumatoid arthritis (RA). "

Related Drugs and Biologics

1.	Catenins
2.	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)
3.	Keratin-7 (Cytokeratin 7)
4.	Hepatocyte Nuclear Factor 1
5.	Vancomycin
6.	Actins (F Actin)
7.	somatostatin receptor 2
8.	zingerone
9.	Aquaporins (Water Channels)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Peritoneal Dialysis
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Adjuvant Chemotherapy
5.	Electroacupuncture