Aquaglyceroporins

A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.

Also Known As:

Multi-Functional Aquaporins; Non-Specific Aquaporins; Aquaporin, Multi-Functional; Aquaporin, Non-Specific; Aquaporins, Multi-Functional; Aquaporins, Non-Specific; Multi Functional Aquaporin; Multi Functional Aquaporins; Non Specific Aquaporin; Non Specific Aquaporins; Aquaglyceroporin; Multi-Functional Aquaporin; Non-Specific Aquaporin

Networked: 70 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Soveral, Graça: 7 articles (04/2021 - 02/2015)
2.	Frühbeck, Gema: 5 articles (09/2015 - 04/2011)
3.	Rodríguez, Amaia: 5 articles (09/2015 - 04/2011)
4.	Calamita, Giuseppe: 4 articles (01/2018 - 04/2011)
5.	Catalán, Victoria: 4 articles (09/2015 - 04/2011)
6.	Gómez-Ambrosi, Javier: 4 articles (09/2015 - 04/2011)
7.	Beitz, Eric: 4 articles (02/2014 - 02/2002)
8.	Verkman, A S: 4 articles (06/2009 - 06/2006)
9.	Agre, Peter: 3 articles (12/2018 - 02/2007)
10.	da Silva, Inês Vieira: 3 articles (01/2018 - 01/2017)

Related Diseases

1.	Leishmaniasis 09/01/2012 - "Leishmania major aquaglyceroporin (LmjAQP1) adventitiously facilitates the uptake of antimonite [Sb(III)], an active form of Pentostam® or Glucantime®, which are the first line of defence against all forms of leishmaniasis. " 01/01/2011 - "Leishmania major aquaglyceroporin LmAQP1 allows adventitious passage of antimonite, an activated form of the drug Pentostam, which is used as the first line treatment for leishmaniasis. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "Transcriptomic analysis revealed that the three aquaglyceroporins, AQP3, AQP7 and AQP9, but not AQP10, are overexpressed in human breast cancer. " 01/01/2023 - "Aquaglyceroporins in Human Breast Cancer." 07/01/2018 - "The present study describes the effect of gene knockdown of the aquaglyceroporin AQP3 on MDA-MB-231 breast cancer cell proliferation, migration, invasion, adherence and response to the chemotherapeutic agent 5-fluorouracil. " 01/01/2023 - "Recent researches have demonstrated that aquaporins (AQPs), including water-selective channels, aquaglyceroporins and superaquaporins, are generally expressed in various tumors, such as lung, colorectal, liver, brain, breast tumors, etc. Therefore, it is imperative to study the accurate relationship between AQPs and tumor, which may provide innovative approaches to treat and prevent tumor development. " 09/27/2012 - "Based on the results, we propose that the aquaglyceroporin AQP3 is required for cytotoxic activity of 5'-DFUR and gemcitabine in the breast cancer cell line MCF7 and the colon adenocarcinoma cell line HT29, and is implicated in cell volume increase and cell cycle arrest."
3.	Obesity 01/01/2023 - "The development of specify pharmacologic modulators able to regulate aquaglyceroporins expression and function, in particular AQP7 in adipose tissue, might constitute a novel approach for controlling obesity and other metabolic disorders." 01/01/2017 - "The development of specify pharmacologic modulators able to regulate aquaglyceroporins expression and function , in particular AQP7 in adipose tissue, might constitute a novel approach for controlling obesity and other metabolic disorders." 02/01/2015 - "Aquaglyceroporins: implications in adipose biology and obesity." 01/01/2018 - "This review addresses the interplay between adipose tissue, liver and muscle, which is the basis of the metabolic syndrome, and highlights the involvement of aquaglyceroporins in obesity and related pathologies and how their regulation in different organs contributes to the features of the metabolic syndrome." 11/01/2016 - "The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice."
4.	Malaria 07/07/2010 - "The applicability of the method is demonstrated by a functional study of the aquaglyceroporin PfAQP from the malaria parasite Plasmodium falciparum. " 12/01/2018 - "Aquaglyceroporin PbAQP is required for efficient progression through the liver stage of Plasmodium infection." 10/01/2016 - "Aquaglyceroporin function in the malaria mosquito Anopheles gambiae." 02/01/2014 - "We further found that H₂O₂ permeability of the aquaglyceroporin from the malaria parasite Plasmodium falciparum was lower despite its wider pore diameter. " 09/21/2010 - "The aquaglyceroporin from Plasmodium falciparum (PfAQP) is a potential drug target for the treatment of malaria. "
5.	Neoplasms (Cancer) 04/15/2021 - "These effects were probably due to inhibition of aquaglyceroporins, membrane water and glycerol channels that are often abnormally expressed in tumors. " 01/01/2021 - "Aquaglyceroporins play a crucial role in supplying cancer cells with glycerol for metabolic needs. " 11/27/2020 - "Aquaporin 9 (AQP9), as an aquaglyceroporin, is expressed in many immune cells and plays important role in tumor initiation and progression. " 01/01/2023 - "Recent researches have demonstrated that aquaporins (AQPs), including water-selective channels, aquaglyceroporins and superaquaporins, are generally expressed in various tumors, such as lung, colorectal, liver, brain, breast tumors, etc. Therefore, it is imperative to study the accurate relationship between AQPs and tumor, which may provide innovative approaches to treat and prevent tumor development. " 01/01/2017 - "Noteworthy, a unique class of gold-based compounds as selective inhibitors of aquaglyceroporin isoforms may provide new chemical tools for therapeutic applications, especially in cancer. "

Related Drugs and Biologics

1.	antimonite
2.	Antimony Sodium Gluconate (Sodium, Stibogluconate)
3.	Aquaporins (Water Channels)
4.	Glycerol (Glycerine)
5.	Lipopolysaccharides
6.	Fluorouracil (Carac)
7.	Arsenic
8.	Proteins (Proteins, Gene)
9.	Lipids
10.	Leptin

Related Therapies and Procedures

1.	Therapeutics
2.	Gastrectomy
3.	Drug Therapy (Chemotherapy)