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GRB2 Adaptor Protein

A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
Also Known As:
Abundant Src Homology Protein; GRB2 Adaptor Protein, Grb3-3 Isoform; Grb3-3 Adaptor Protein; GRB2 Adaptor Protein, Grb3 3 Isoform; Growth Factor Receptor Bound Protein 2; Growth Factor Receptor-Bound Protein-2
Networked: 30 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Burke, Terrence R: 4 articles (12/2008 - 10/2005)
2. Giubellino, Alessio: 3 articles (12/2008 - 07/2007)
3. Bottaro, Donald P: 3 articles (12/2008 - 07/2007)
4. Hsu, Shu-Chun: 2 articles (01/2015 - 05/2013)
5. Chung, Jing-Gung: 2 articles (01/2015 - 05/2013)
6. Shi, Zhen-Dan: 2 articles (12/2008 - 10/2005)
7. Hu, Man: 1 article (10/2015)
8. Xia, Tingyi: 1 article (10/2015)
9. Yue, Xiao: 1 article (10/2015)
10. Lan, Fengming: 1 article (10/2015)

Related Diseases

1. Neoplasms (Cancer)
2. B-Cell Lymphoma (Lymphoma, B Cell)
12/01/2009 - "These findings support a role for growth factor receptor-bound protein 2 in the diagnostically challenging workup of classical Hodgkin lymphoma versus primary mediastinal large B-cell lymphoma and warrant further studies to evaluate the biologic significance of growth factor receptor-bound protein 2 in the pathogenesis of classical Hodgkin lymphoma."
12/01/2009 - "Growth factor receptor-bound protein 2 protein expression was detected by Western blotting in all lymphoma cell lines tested with higher levels in primary mediastinal large B-cell lymphoma compared with classical Hodgkin lymphoma cell lines. "
12/01/2009 - "We sought to characterize growth factor receptor-bound protein 2 protein expression in reactive tonsillar tissues and lymphoma tissues obtained from diagnostic biopsies of classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, diffuse large B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and 20 low-grade B-cell lymphomas. "
12/01/2009 - "Strong, cytoplasmic growth factor receptor-bound protein 2 expression was seen in the neoplastic cells of follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, splenic marginal zone lymphoma, primary mediastinal large B-cell lymphoma, diffuse large B-cell lymphoma, and nodular lymphocyte predominant Hodgkin lymphoma. "
05/01/2009 - "BBC3 (B-cell lymphoma 2 binding component 3), CD69 (cluster of differentiation 69), CDKN1A (cyclin-dependent kinase inhibitor 1A), DUSP8 (dual specificity phosphatase 8) EGR1 (early growth response 1), EGR4 (early growth response 4), GADD45A (growth arrest and DNA-damage-inducible, alpha), GRAP (growth factor receptor-bound protein 2-related adaptor protein), LAP1B (TOR1AIP1; torsin A interacting protein 1), IFNG (interferon gamma), ISG20L1 (interferon-stimulated exonuclease gene 20kDa - like 1), c-JUN (jun oncogene), MDM2 (mouse double minute 2), PCNA (proliferating cell nuclear antigen), PLK2 (polo-like kinase 2), RND1 (rho family GTPase 1), TNFSF9 (tumour necrosis factor superfamily member 9) and TRAF4 (tumour necrosis factor receptor-associated factor 4). "
3. Hodgkin Disease (Hodgkin's Disease)
4. Fatty Liver
5. Squamous Cell Carcinoma (Epidermoid Carcinoma)

Related Drugs and Biologics

1. Phosphotransferases (Kinase)
2. Phospholipase C gamma
3. Palmitic Acid (Hexadecanoic Acid)
4. Paraffin
5. Botulinum Toxins (Botulinum Toxin)
6. Shc Signaling Adaptor Proteins
7. Proteins (Proteins, Gene)
8. Protein Kinases (Protein Kinase)
9. Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
10. Insulin Receptor Substrate Proteins

Related Therapies and Procedures

1. Therapeutics