|1.||Machesky, Laura M: 10 articles (10/2014 - 01/2003)|
|2.||Insall, Robert H: 7 articles (01/2013 - 09/2003)|
|3.||Pollard, Thomas D: 5 articles (02/2015 - 02/2003)|
|4.||Dyachok, Julia: 5 articles (10/2011 - 11/2004)|
|5.||Pollard, T D: 5 articles (11/2001 - 04/2000)|
|6.||Rottner, Klemens: 4 articles (09/2013 - 10/2002)|
|7.||Smith, Laurie G: 4 articles (03/2006 - 02/2004)|
|8.||Higgs, H N: 4 articles (12/2001 - 04/2000)|
|9.||Way, Michael: 3 articles (11/2015 - 10/2002)|
|10.||Stradal, Theresia E B: 3 articles (09/2013 - 10/2002)|
05/01/2013 - "In vitro studies have shown that SCAR/WAVE activates the Arp2/3 complex to generate actin filaments, which in many cell types are organised into lamellipodia that are thought to have an important role in cell migration. "
12/11/2001 - "A recent study has revealed marked differences in the ability of two nucleation-promoting factors - N-WASP and Scar/WAVE1 - to activate the Arp2/3 complex. "
01/01/2014 - "Abp1 is able to indirectly trigger Arp2/3 complex-mediated actin nucleation and interacts with both WASP and Scar. "
01/21/2013 - "The Scar/WAVE regulatory complex (WRC) drives lamellipodia assembly via the Arp2/3 complex, whereas the Arp2/3 activator N-WASP is not essential for 2D migration but is increasingly implicated in 3D invasion. "
08/20/2012 - "We show that, unexpectedly, Dictyostelium discoideum SCAR knockouts could still spread, migrate, and chemotax using pseudopods driven by the Arp2/3 complex. "
|2.||Wiskott-Aldrich Syndrome (Syndrome, Wiskott-Aldrich)
09/15/2002 - "In this study, the signaling pathways leading to Arp2/3 complex activation, actin assembly, and shape change were investigated in platelets isolated from patients with Wiskott-Aldrich Syndrome (WAS), that is, who lack WASp, and in WASp-deficient mouse platelets. "
11/01/2010 - "Arp2/3 complex mediates the nucleation of actin filaments in multiple subcellular processes, and is activated by nucleation-promoting factors (NPFs) from the Wiskott-Aldrich Syndrome family. "
12/01/2005 - "Specifically, members of the actin-related protein2/3 (ARP2/3) complex and the Wiskott-Aldrich syndrome Verprolin-homologous (WAVE) complex have been identified. "
01/01/2001 - "Wiskott-Aldrich-syndrome mutations in the WA domain that alter nucleation by the Arp2/3 complex over a tenfold range without affecting affinity for actin or the Arp2/3 complex indicate that there may be an activation step in the nucleation pathway. "
07/01/2000 - "The polarization defect of Wiskott-Aldrich syndrome macrophages is linked to dislocalization of the Arp2/3 complex."
12/09/2013 - "At the molecular level, the mesenchymal-but not the epithelial-isoform of Exo70 interacts with the Arp2/3 complex and stimulates actin polymerization for tumor invasion. "
10/01/2013 - "The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration."
04/15/2007 - "Changes in the expression of genes that occur uniquely in the invasive subpopulation of tumor cells in the PyMT mammary tumors that fall on the Arp2/3 complex, capping protein and cofilin pathways show a pattern like that seen previously in invasive tumor cells from the MTLn3 cell line-derived tumors. "
08/30/2004 - "The consistent decrease of the Arp2/3 complex genes and its important role in actin organization suggested that the decrease could be involved in cancer phenotypes, such as dysplastic morphology."
03/01/2013 - "Molecular studies revealed that RHOJ alters actin cytoskeletal dynamics by inducing the phosphorylation of LIMK, cofilin, and p41-ARC (ARP2/3 complex subunit) in a PAK1-dependent manner in vitro and in tumor xenografts. "
|4.||Stomach Neoplasms (Stomach Cancer)
08/30/2004 - "In this study, gene expressions of the seven subunits of the Arp2/3 complex, including p41-Arc, and their methylation statuses were analyzed in human gastric cancers. "
08/30/2004 - "Decreased expression of the seven ARP2/3 complex genes in human gastric cancers."
08/30/2004 - "We recently identified decreased expression of a gene for one of seven subunits of the Arp2/3 complex, the p41-Arc gene, and silencing of a filamin gene, the FLNc gene, in human gastric cancers. "
07/01/2002 - "Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers."
|5.||Pancreatic Neoplasms (Pancreatic Cancer)
01/01/2013 - "In addition, we show cell line-specific differences in ARP2/3 complex subunit dependency on cell migratory potential, and suggest ARPC4 to be one of the key members of the ARP2/3 complex in pancreatic cancer."
01/01/2013 - "We offer comprehensive expression data on the ARP2/3 complex members for pancreatic cancer and normal pancreas. "
01/01/2013 - "The expression of the seven ARP2/3 complex subunits was assessed in pancreatic cancer cell lines and in normal pancreatic samples by quantitative RT-PCR. "
01/01/2013 - "Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration."
04/01/2009 - "Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer."
|1.||Proteins (Proteins, Gene)
|3.||Small Interfering RNA (siRNA)
|4.||Wiskott-Aldrich Syndrome Protein
|5.||Actin-Related Protein 2
|6.||Actins (F Actin)
|7.||GTP Phosphohydrolases (GTPases)
|8.||Cyclic AMP Receptors (Cyclic AMP Receptor)
|9.||Wiskott-Aldrich Syndrome Protein Family
|1.||Heterologous Transplantation (Xenotransplantation)