Cyclin-Dependent Kinase 6

Cyclin-dependent kinase 6 associates with CYCLIN D and phosphorylates RETINOBLASTOMA PROTEIN during G1 PHASE of the CELL CYCLE. It helps regulate the transition to S PHASE and its kinase activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P18.

Also Known As:

Networked: 129 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shamsi, Anas: 5 articles (07/2022 - 05/2020)
2.	Yousuf, Mohd: 5 articles (07/2022 - 05/2020)
3.	Hassan, Md Imtaiyaz: 4 articles (07/2022 - 05/2020)
4.	Khan, Parvez: 4 articles (07/2022 - 05/2020)
5.	Haque, Qazi Mohd Rizwanul: 3 articles (07/2022 - 10/2020)
6.	Hu, Miaofen G: 3 articles (01/2022 - 02/2009)
7.	Islam, Asimul: 3 articles (01/2022 - 05/2020)
8.	Shahbaaz, Mohd: 3 articles (01/2021 - 05/2020)
9.	Zhang, Jing: 3 articles (01/2021 - 03/2014)
10.	Elasbali, Abdelbaset Mohamed: 2 articles (07/2022 - 01/2022)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 04/01/2020 - "Furthermore, mechanistic analyses revealed that ENO1 enhanced cell proliferation by accelerating G1 progression and upregulating G1 phase cyclin-dependent kinase 6 (CDK6), and improved cell survival by upregulating p38 in the MAPK cascade and increasing p-AKT in the AKT cascade, in particular in lung cancer cell lines. " 01/01/2021 - "Targeting cyclin-dependent kinase 6 by vanillin inhibits proliferation of breast and lung cancer cells: Combined computational and biochemical studies."
2.	Retinoblastoma (Glioblastoma, Retinal) 06/24/2008 - "Transfection of microRNA-124 or microRNA-137 also induced G1 cell cycle arrest in U251 and SF6969 glioblastoma multiforme cells, which was associated with decreased expression of cyclin-dependent kinase 6 and phosphorylated retinoblastoma (pSer 807/811) proteins. " 01/01/2020 - "Among 140 patients with genetic alternations, patients with cell cycle regulator mutations (cyclin-dependent kinase 6 gene [CDK6], retinoblastoma-like 1 gene [RBL1], retinoblastoma-like 2 gene [RBL2], and retinoblastoma 1 gene [RB1]) had significantly improved PFS with alisertib/paclitaxel versus with placebo/paclitaxel (3.68 versus 1.80 months, respectively [HR = 0.395, 95% CI: 0.239-0.654, p = 0.0003]), and overall survival (7.20 versus 4.47 months, respectively [HR = 0.427, 95% CI: 0.259-0.704, p = 0.00085]). "
3.	Obesity 01/01/2018 - "We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit significant increases beige cell formation, enhanced energy expenditure, better glucose tolerance, and improved insulin sensitivity, and are more resistant to high-fat diet-induced obesity. "
4.	Insulin Resistance 01/01/2018 - "We demonstrate that mice lacking the CDK6 protein or its kinase domain (K43M) exhibit significant increases beige cell formation, enhanced energy expenditure, better glucose tolerance, and improved insulin sensitivity, and are more resistant to high-fat diet-induced obesity. "
5.	Neoplasms (Cancer) 01/01/2023 - "Emerging evidence manifests that cyclin-dependent kinase 6 (CDK6) plays an essential part in the initiation and progression of several types of human cancer, and its descending expression is correlated with an adverse prognosis. " 07/31/2022 - "Cyclin dependent kinase 6 (CDK6) plays an essential role in cancer progression and development as its overexpression is associated with tumor development and progression. " 01/01/2021 - "A translocation involving the cyclin-dependent kinase 6 (CDK6) gene [t(CDK6)] is a rare but recurrent abnormality in B-cell neoplasms. " 10/27/2020 - "Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in the progression of different types of cancers. " 11/01/2019 - "The results also revealed that miR-934 inhibition dramatically decreased human BC cell monolayer growth in vitro and xenograft tumor growth in vivo; the outcomes were accompanied by CDK6 protein down-regulation and G0-G1 cell cycle arrest. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Paclitaxel (Taxol)
3.	Glucose (Dextrose)
4.	MLN 8237
5.	Proteins (Proteins, Gene)
6.	Messenger RNA (mRNA)
7.	Cyclin D1
8.	MicroRNAs (MicroRNA)
9.	Cyclin-Dependent Kinases (cdk Proteins)
10.	Interferon Regulatory Factors

Related Therapies and Procedures

1.	Therapeutics