|1.||Puig, Susana: 3 articles (09/2015 - 02/2011)|
|2.||Niesvizky, Ruben: 3 articles (08/2012 - 12/2005)|
|3.||Di Liberto, Maurizio: 3 articles (08/2012 - 12/2005)|
|4.||Chen-Kiang, Selina: 3 articles (08/2012 - 12/2005)|
|5.||Ely, Scott: 3 articles (08/2012 - 12/2005)|
|6.||Flaherty, Keith T: 3 articles (01/2012 - 07/2008)|
|7.||Hirose, Takanori: 3 articles (10/2006 - 01/2002)|
|8.||Wenzel, Jörg: 3 articles (08/2006 - 01/2006)|
|9.||Tormo, Damia: 3 articles (08/2006 - 01/2006)|
|10.||Ferrer, Aleix: 3 articles (08/2006 - 01/2006)|
|1.||Breast Neoplasms (Breast Cancer)
08/01/2015 - "Overexpression of miR-124 suppressed CDK4 protein expression and attenuated cell viability, proliferation, and cell cycle progression in MCF-7 and MDA-MB-435S breast cancer cells in vitro. "
11/01/2014 - "Cyclin-dependent kinase 4/6 inhibitors in breast cancer therapy."
03/01/2004 - "The effect of Brn-3b on the growth regulatory CDK4 protein provides a further mechanism by which Brn-3b can regulate breast cancer cell growth and indicates that it can do this by activating as well as repressing specific target genes."
03/01/2004 - "Here we have used gene arrays to identify several other targets for Brn-3b in human breast cancer cells, including cyclin-dependent kinase 4 (CDK4). "
07/01/2000 - "Frequent deletions or mutations of the INK4 gene, which encodes the cyclin-dependent kinase 4 inhibitor p16INK4a, have been documented in various human cancers, but little is known about the role of this tumor suppressor gene in primary breast cancer. "
|2.||Melanoma (Melanoma, Malignant)
09/01/2015 - "A few years later cyclin-dependent kinase 4 (CDK4) was also identified as a melanoma susceptibility gene. "
08/01/2006 - "Impaired cell-cycle control, which is a hallmark of both familial and sporadic melanoma, promotes slowly growing carcinogen-induced melanomas in the skin of mice carrying a mutated cyclin-dependent kinase 4 (CDK4(R24C)). "
03/01/2006 - "We primarily used a unique Utah genealogical resource to identify independent melanoma prone families whom we tested for mutations in CDKN2A, cyclin-dependent kinase 4, and alternate reading frame. "
12/01/2004 - "Germline mutations in two genes that play a pivotal role in controlling cell cycle and division--CDKN2A and cyclin-dependent kinase 4 (CDK4)--have been detected in autosomal, dominant, high penetrance familial melanoma cases. "
04/01/2003 - "A mutation of the p16(INK4a)-binding domain of the cyclin dependent kinase 4 (CDK4) gene, R24C, has been reported in some cases of melanoma. "
|3.||Retinoblastoma (Glioblastoma, Retinal)
11/01/1999 - "In contrast, the expressions of other cell cycle regulated genes and proto-oncogene, including the cyclin-dependent kinase 4 (cdk4), retinoblastoma, p16INK4a and p21H-ras, were not altered. "
01/01/1998 - "Members of the INK4 protein family specifically inhibit cyclin-dependent kinase 4 (cdk4) and cdk6-mediated phosphorylation of the retinoblastoma susceptibility gene product (Rb). "
06/15/1997 - "In the present study, we analyzed human ovarian carcinoma cell lines for abnormalities in the tumor suppressor gene Rb (retinoblastoma) and in cyclin-dependent kinase 4 (CDK4) inhibitor genes (p16INK4 and p15INK4B) using molecular biology techniques. "
01/09/2004 - "Gankyrin interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6 (CDK4/6), increases phosphorylation at specific residues of Rb by CDK4/6 in vivo, and promotes tumorigenesis. "
06/01/2003 - "Human pituitary adenomas infrequently contain inactivation of retinoblastoma 1 gene and activation of cyclin dependent kinase 4 gene."
|4.||Brain Neoplasms (Brain Tumor)
11/01/2015 - "Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model."
01/01/1998 - "We have measured the gene dosage of the epidermal growth factor receptor (EGFR), mouse double minute 2 (MDM2), and cyclin-dependent kinase 4 (CDK4) genes in a series of brain tumor specimens and correlated their amplification status with standard prognostic factors and survival. "
06/01/1996 - "Alterations in P16ink4 or in the gene encoding one of its ligands, cyclin-dependent kinase 4 (CDK4), have been reported in human glioma cell lines and primary tumors but not in primitive neuroectodermal tumors (PNETs), the most common malignant brain tumor of childhood. "
|5.||Alzheimer Disease (Alzheimer's Disease)
01/01/2013 - "Efficacy of cyclin dependent kinase 4 inhibitors as potent neuroprotective agents against insults relevant to Alzheimer's disease."
05/01/1999 - "Two regulators of the eukaryotic cell cycle, cell division cycle 2 (cdc2) and cyclin-dependent kinase 4 (cdk4), have been reported to be related to Alzheimer's disease (AD) pathology, and especially to hyperphosphorylated tau protein. "
|4.||Staphylococcal Protein A (A, Protein)
|6.||Cyclin-Dependent Kinase Inhibitor p16
|8.||6- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- one
|9.||Proteins (Proteins, Gene)
|10.||Messenger RNA (mRNA)
|1.||Heterologous Transplantation (Xenotransplantation)
|3.||Prostatectomy (Retropubic Prostatectomy)
|4.||Drug Therapy (Chemotherapy)