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Cyclin-Dependent Kinase 4

Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.
Also Known As:
Cdk4 Cyclin-Dependent Kinase; Cdk4 Protein; Cell Division Protein Kinase 4; Cyclin D-Dependent Kinase CDK4; PSK-J3 Kinase; p34PSK-J3 Kinase; Cdk4 Cyclin Dependent Kinase; Cyclin D Dependent Kinase CDK4; Cyclin Dependent Kinase 4; Cyclin-Dependent Kinase, Cdk4; PSK J3 Kinase; Protein Kinase, Cdk4; p34PSK J3 Kinase; Cdk4 Protein Kinase
Networked: 285 relevant articles (5 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Puig, Susana: 3 articles (09/2015 - 02/2011)
2. Niesvizky, Ruben: 3 articles (08/2012 - 12/2005)
3. Di Liberto, Maurizio: 3 articles (08/2012 - 12/2005)
4. Chen-Kiang, Selina: 3 articles (08/2012 - 12/2005)
5. Ely, Scott: 3 articles (08/2012 - 12/2005)
6. Flaherty, Keith T: 3 articles (01/2012 - 07/2008)
7. Hirose, Takanori: 3 articles (10/2006 - 01/2002)
8. Wenzel, Jörg: 3 articles (08/2006 - 01/2006)
9. Tormo, Damia: 3 articles (08/2006 - 01/2006)
10. Ferrer, Aleix: 3 articles (08/2006 - 01/2006)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Melanoma (Melanoma, Malignant)
3. Retinoblastoma (Glioblastoma, Retinal)
4. Brain Neoplasms (Brain Tumor)
5. Alzheimer Disease (Alzheimer's Disease)

Related Drugs and Biologics

1. Cyclin D1
2. letrozole (Femara)
3. Phosphotransferases (Kinase)
4. Staphylococcal Protein A (A, Protein)
5. Neuroprotective Agents
6. Cyclin-Dependent Kinase Inhibitor p16
7. Retinoblastoma Protein
8. 6- acetyl- 8- cyclopentyl- 5- methyl- 2- (5- piperazin- 1- ylpyridin- 2- ylamino)- 8H- pyrido(2,3- d)pyrimidin- 7- one
9. Proteins (Proteins, Gene)
10. Messenger RNA (mRNA)

Related Therapies and Procedures

1. Heterologous Transplantation (Xenotransplantation)
2. Therapeutics
3. Prostatectomy (Retropubic Prostatectomy)
4. Drug Therapy (Chemotherapy)