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Cyclin-Dependent Kinase 2

A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.
Also Known As:
CDK2 Protein; Cdc2-Related Protein Kinase; p33cdk2 Kinase; Cdc2 Related Protein Kinase; Cyclin Dependent Kinase 2; Cdk2 Protein Kinase
Networked: 343 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Keyomarsi, Khandan: 5 articles (01/2016 - 03/2004)
2. Li, Ling: 3 articles (01/2022 - 01/2015)
3. El-Kady, Dina S: 3 articles (07/2019 - 01/2019)
4. Loganathan, Chitra: 2 articles (12/2022 - 08/2021)
5. Sakayanathan, Penislusshiyan: 2 articles (12/2022 - 08/2021)
6. Thayumanavan, Palvannan: 2 articles (12/2022 - 08/2021)
7. Vijayan, Sudha: 2 articles (12/2022 - 08/2021)
8. Hao, Jie: 2 articles (05/2022 - 10/2018)
9. Wang, Wei: 2 articles (01/2022 - 01/2021)
10. Min, Jaeki: 2 articles (12/2021 - 01/2018)

Related Diseases

1. Neoplasms (Cancer)
2. Myocardial Ischemia (Ischemic Heart Diseases)
3. Infections
4. Carcinogenesis
04/01/1995 - "These results suggest a sequential pattern of multiple derangements in factors regulating cdk2 protein function during mammary tumorigenesis. "
01/01/2016 - "Cyclin E and its co-activator, phospho-cyclin-dependent kinase 2 (p-CDK2), regulate G1 to S phase transition and their deregulation induces oncogenesis. "
07/22/2011 - "MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis."
10/03/1996 - "We observed a marked decrease in CDC2 and CDK2 kinase activity associated with a corresponding decrease in the amount of CDC2 but not CDK2 protein; a decreased growth potential of Adp21WAF1/CIP1-infected cells demonstrated by diminished [3H]thymidine incorporation, increased cell doubling time and G1-arrested cell cycle; an association between Adp21WAF1/CIP1-infected cells and inhibition of aneuploid cell accumulation; and an alteration of the malignant phenotype of cells was evidenced by the loss of anchorage-independent growth in soft agar and the failure to induce tumorigenesis in both peripheral and intracerebral xenograft models, including the prevention of tumor formation Adp21WAF1/CIP1 infection 2 days post tumor cell implantation. "
12/01/2010 - "These transgenic and transplantable models have already aided in the discovery of oncogenic and growth-suppressive microRNAs and in the identification of a novel antineoplastic mechanism of action for inhibitors of cyclin-dependent kinase 2. This review discusses the general utility of murine carcinogen-induced and transgenic models of lung carcinogenesis and describes the optimization of cyclin E-overexpressing lung carcinogenesis models and their use in testing candidate agents for the prevention and therapy of lung cancer."
5. Reperfusion Injury

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3. Cisplatin (Platino)
4. Melatonin
5. Agar
6. Bone Morphogenetic Protein 15
7. Growth Differentiation Factor 9
8. Reactive Oxygen Species (Oxygen Radicals)
9. Thymidine
10. Steroids

Related Therapies and Procedures

1. Therapeutics
2. Chinese Traditional Medicine (Traditional Chinese Medicine)
3. Drug Therapy (Chemotherapy)
4. Contraception (Birth Control)