Nuclear Respiratory Factor 1

A transcription factor that controls the expression of variety of proteins including CYTOCHROME C and 5-AMINOLEVULINATE SYNTHETASE. It plays an important role in maintenance of the RESPIRATORY CHAIN of MITOCHONDRIA.
Also Known As:
NRF1 Transcription Factor; Transcription Factor, NRF1
Networked: 27 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Aras, Adem Bozkurt: 4 articles (10/2015 - 01/2015)
2. Cosar, Murat: 3 articles (10/2015 - 01/2015)
3. Guven, Mustafa: 3 articles (10/2015 - 01/2015)
4. Akman, Tarik: 2 articles (10/2015 - 01/2015)
5. Silan, Coskun: 2 articles (01/2015 - 01/2015)
6. Kalkan, Yıldıray: 2 articles (01/2015 - 01/2015)
7. Bal, Ercan: 1 article (10/2015)
8. Sehitoglu, Muserref Hilal: 1 article (10/2015)
9. Tokmak, Mehmet: 1 article (10/2015)
10. Golge, Umut Hatay: 1 article (10/2015)

Related Diseases

1. Sepsis (Septicemia)
2. Brain Ischemia (Cerebral Ischemia)
3. Anoxia (Hypoxia)
12/01/2013 - "Nuclear respiratory factor 1 (NRF1) and transcription factor A (Tfam) mRNA and BNIP-3 protein were not influenced by hypoxia in overloaded muscles, whereas Pgc-1α mRNA and protein contents did not correlate with changes in oxidative capacity. "
11/11/2011 - "OSU-53 also modulated energy homeostasis by suppressing fatty acid biosynthesis and shifting the metabolism to oxidation by up-regulating the expression of key regulators of mitochondrial biogenesis, such as a peroxisome proliferator-activated receptor γ coactivator 1α and the transcription factor nuclear respiratory factor 1. Moreover, OSU-53 suppressed LPS-induced IL-6 production, thereby blocking subsequent Stat3 activation, and inhibited hypoxia-induced epithelial-mesenchymal transition in association with the silencing of hypoxia-inducible factor 1a and the E-cadherin repressor Snail. "
06/01/2012 - "Through a two-way ANOVA, a significant interaction (treatment × treatment duration) effect was detected on expression levels of mRNAs for hypoxia-inducible factor 1α, vascular endothelial growth factor, myoglobin, nuclear respiratory factor 1, citrate synthase, carbonic anhydrase 3, monocarboxylate transporter 1, copper/zinc superoxide dismutase, glutathione S-transferase pi, and manganese superoxide dismutase. "
06/01/2012 - "The study's purpose was to determine in a rat obesity model the effects of normoxic training, sedentary hypoxic living, or hypoxic living plus training on the skeletal muscle messenger RNA (mRNA) levels of 14 genes involved in oxygen sensing (hypoxia-inducible factor 1α, vascular endothelial growth factor, myoglobin), glucose metabolism (glucose transporter 4, muscle phosphofructokinase), mitochondrial biogenesis (peroxisome proliferator-activated receptor γ coactivator 1-α, nuclear respiratory factor 1) and function (citrate synthase, mitochondrial-encoded cytochrome oxidase subunit 1), pH regulation (monocarboxylate transporter 1, carbonic anhydrase 3), and antioxidant defense (manganese superoxide dismutase, copper/zinc superoxide dismutase, glutathione S-transferase pi). "
4. Shock
5. Type 2 Diabetes Mellitus (MODY)

Related Drugs and Biologics

1. Superoxide Dismutase
2. mitochondrial transcription factor A
3. Caspase 3 (Caspase-3)
4. Cysteine (L-Cysteine)
5. Carbon Monoxide
6. syringaldehyde
7. Messenger RNA (mRNA)
8. PPAR gamma
9. Insulin (Novolin)
10. Electron Transport Complex IV (Cytochrome c Oxidase)

Related Therapies and Procedures

1. Resistance Training
2. Aftercare (After-Treatment)