|1.||May, Victor: 3 articles (09/2014 - 11/2008)|
|2.||Braas, Karen M: 3 articles (09/2014 - 11/2008)|
|3.||Arranz, Alicia: 3 articles (07/2006 - 01/2002)|
|4.||Gomariz, Rosa P: 3 articles (07/2006 - 01/2002)|
|5.||Abad, Catalina: 3 articles (07/2006 - 01/2002)|
|6.||Leceta, Javier: 3 articles (07/2006 - 01/2002)|
|7.||Hammack, Sayamwong E: 2 articles (09/2014 - 02/2011)|
|8.||Ressler, Kerry J: 2 articles (01/2013 - 02/2011)|
|9.||Juarranz, Yasmina: 2 articles (07/2006 - 05/2005)|
|10.||Martínez, Carmen: 2 articles (07/2006 - 05/2005)|
|1.||Septic Shock (Toxic Shock Syndrome)
07/01/2006 - "PAC1 receptor: emerging target for septic shock therapy."
01/22/2002 - "In this study, we used a knockout for the PACAP receptor (PAC1(-/-)) to demonstrate an important protective role for PAC1 receptor in endotoxic shock. "
05/01/2005 - "Analysis of the role of the PAC1 receptor in neutrophil recruitment, acute-phase response, and nitric oxide production in septic shock."
01/22/2002 - "Moreover, our results indicate that PAC1 receptor acts in vivo as an anti-inflammatory receptor, at least in part, by attenuating lipopolysaccharide (LPS)-induced production of proinflammatory IL-6, which appears to be the main cytokine regulating the expression of the majority of the acute phase protein genes, which are an important deleterious component of septic shock. "
05/01/2005 - "The present study deepens in the protective role of PAC1 receptor in septic shock, elucidating its involvement in the modulation of neutrophil recruitment and in the expression of different molecular sensors such as intercellular adhesion molecule-1, vascular cell adhesion molecule-1, fibrinogen, serum amyloid A, and nitric oxide as important, systemic players of the development of septic shock. "
|2.||Abnormal Reflex (Hyperreflexia)
|3.||Hypoglycemia (Reactive Hypoglycemia)
|4.||Post-Traumatic Stress Disorders (PTSD)
08/15/2013 - "PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors."
02/01/2012 - "CRF(1) receptor single nucleotide polymorphisms (SNPs) can confer susceptibility or resilience to childhood trauma while a SNP for the PAC1 receptor, another class B1 GPCR, has been linked genetically to PTSD. "
09/01/2014 - "In aggregate with recent associations of PACAP/PAC1 receptor dysregulation with altered stress responses including post-traumatic stress disorder, these data suggest that BNST PACAP/PAC1 receptor signaling mechanisms may coordinate the behavioral and endocrine consequences of stress. "
01/01/2013 - "PACAP and the PAC1 receptor in post-traumatic stress disorder."
02/24/2011 - "Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor."
|5.||Migraine Disorders (Migraine)
12/01/2010 - "The present thesis contributes to our knowledge on migraine pathophysiology and suggests PAC1 receptor antagonism as a new target for migraine treatment."
10/07/2015 - "Furthermore, the PAC1 receptor may be an appropriate molecular target for migraine therapeutics. "
03/01/2014 - "PACAP38 has a much higher affinity for the PAC1 receptor and we therefore suggest that migraine induction by PACAP38 may be because of activation of the PAC1 receptor, which may be a future anti-migraine drug target. "
|1.||Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
|2.||Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
|3.||Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
|4.||Fibrinogen (Factor I)
|5.||Pituitary Adenylate Cyclase-Activating Polypeptide Receptors
|6.||Nitric Oxide (Nitrogen Monoxide)
|10.||Serum Amyloid A Protein (Serum Amyloid A)
|1.||Intensive Care (Surgical Intensive Care)