|1.||Oldfield, Eric: 5 articles (03/2015 - 10/2004)|
|2.||Rogers, Michael J: 4 articles (10/2006 - 01/2002)|
|3.||Messa, Caterina: 3 articles (07/2012 - 01/2004)|
|4.||Caruso, Maria Gabriella: 3 articles (07/2012 - 01/2004)|
|5.||Notarnicola, Maria: 3 articles (07/2012 - 01/2004)|
|6.||Docampo, Roberto: 3 articles (04/2011 - 10/2004)|
|7.||Thompson, Keith: 3 articles (10/2006 - 01/2002)|
|8.||Liu, Yi-Liang: 2 articles (03/2015 - 06/2013)|
|9.||Morita, Craig T: 2 articles (05/2013 - 04/2005)|
|10.||Rodriguez, Juan B: 2 articles (04/2011 - 03/2008)|
02/01/2001 - "We found a clear correlation between the ability to inhibit farnesyl diphosphate synthase in vitro, to inhibit protein prenylation in cell-free extracts and in purified osteoclasts in vitro, and to inhibit bone resorption in vivo. "
04/21/2005 - "We report the design, synthesis and testing of a series of novel bisphosphonates, pyridinium-1-yl-hydroxy-bisphosphonates, based on the results of comparative molecular similarity indices analysis and pharmacophore modeling studies of farnesyl diphosphate synthase (FPPS) inhibition, human Vgamma2Vdelta2 T cell activation and bone resorption inhibition. "
06/01/2013 - "Here, we used this approach combined with similarity searches and experimental inhibition assays to identify several low micromolar, non-bisphosphonate inhibitors, bisamidines, of farnesyl diphosphate synthase (FPPS), an enzyme targeted by some anticancer and antimicrobial agents and for the treatment of bone resorption diseases. "
06/01/2013 - "N-BPs reduce Oc bone resorption by inhibiting the enzyme farnesyl diphosphate synthase (FPPS), an effect counteracted by geranylgeraniol (GGOH), which restores geranylgeranylation downstream of FPPS. "
06/01/2008 - "N-BPs suppress bone resorption by inhibiting farnesyl diphosphate synthase in mevalonate pathway, reducing protein-prenylation, consequently disrupting the membrance structure in osteoclasts. "
03/01/2006 - "I6A arrested tumor cell proliferation by inhibiting farnesyl diphosphate synthase (FPPS) and protein prenylation. "
03/01/2006 - "N6-isopentenyladenosine arrests tumor cell proliferation by inhibiting farnesyl diphosphate synthase and protein prenylation."
05/01/2013 - "Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid."
03/12/2015 - "Farnesyl diphosphate synthase (FPPS) is an important drug target for bone resorption, cancer, and some infectious diseases. "
02/01/2010 - "This view finds support from the studies with synthetic inhibitors of geranylgeranyl-/farnesyl-diphosphate synthetase or transferase: The inhibitors are reported to overcome multidrug resistance in cancer cell lines or xenografts in animals. "
|3.||Colorectal Neoplasms (Colorectal Cancer)
01/01/2004 - "Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis."
07/01/2012 - "In this review, we summarize recent progress regarding the study of the main enzymes of lipid metabolism involved in colorectal cancer development, namely of a) farnesyltransferase (Ftase), a cytosolic enzyme that catalyzes the first step in the protein farnesylation; b) farnesyl diphosphate synthase (FPPS, which yields FPP, a substrate for Ftase; c) fatty acid synthase (FAS), an enzyme required for the conversion of acetyl-CoA and malonyl-CoA to palmitate; and d) lipoprotein lipase (LPL), the crucial enzyme for intravascular catabolism of triglyceride-rich lipoproteins. "
|4.||Glioblastoma (Glioblastoma Multiforme)
04/26/2010 - "Increased expression of farnesyl diphosphate synthase (FPPS) by stable transfection appeared to attenuate paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells. "
04/26/2010 - "Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells."
01/01/2015 - "In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway including 3'-hydroxy-3'-methylglutaryl-coenzyme A reductase, MVA kinase, farnesyl diphosphate synthase and farnesyl diphosphate farnesyl transferase 1, in the human glioblastoma multiforme cell line, U343 cells, and in normal human astrocytes, NHAs. "
|5.||Chagas Disease (American Trypanosomiasis)
|7.||farnesyl pyrophosphate (farnesyl diphosphate)
|8.||Malonyl Coenzyme A (Malonyl CoA)
|10.||Lipoprotein Lipase (Diacylglycerol Lipase)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)