|1.||Hashimoto, Hitoshi: 36 articles (09/2015 - 11/2003)|
|2.||Reglodi, Dora: 32 articles (01/2015 - 07/2006)|
|3.||Shioda, Seiji: 30 articles (10/2015 - 08/2002)|
|4.||Baba, Akemichi: 28 articles (01/2014 - 11/2003)|
|5.||Nakamachi, Tomoya: 26 articles (10/2015 - 04/2004)|
|6.||Shintani, Norihito: 26 articles (01/2014 - 11/2003)|
|7.||Reglodi, D: 24 articles (09/2015 - 01/2000)|
|8.||Tamas, Andrea: 24 articles (01/2015 - 07/2006)|
|9.||Kiss, P: 19 articles (09/2015 - 07/2006)|
|10.||May, Victor: 18 articles (08/2015 - 04/2006)|
06/01/2000 - "Treatment with PACAP38 starting 8 or 12 hours after the onset of ischemia did not result in a significant reduction of the infarct size, although infarct volumes tended to be smaller than in the control groups. "
01/10/2008 - "The aim of the present study was to investigate whether PACAP is protective against in vitro ischemia/reperfusion-induced apoptosis in cardiomyocytes. "
04/01/2009 - "We have demonstrated earlier that PACAP has protective effects against in vitro ischemia/reperfusion-induced apoptosis in cardiomyocytes. "
11/01/2008 - "PACAP has protective effects against myeloma kidney injury and renal ischemia. "
01/10/2008 - "In summary, our results show that PACAP has protective effects against ischemia/reperfusion-induced cardiomyocyte apoptosis and provides new insights into the signaling mechanisms involved in the PACAP-mediated anti-apoptotic effects."
|2.||Wounds and Injuries (Trauma)
07/01/2010 - "PACAP is known for its strong cytoprotective effects, which are present endogenously as well, as proven by knockout studies and results showing that PACAP is up-regulated following diverse injuries. "
10/01/2015 - "PACAP as a neuroprotective factor in ischemic neuronal injuries."
07/01/2015 - "A New Recombinant PACAP-Derived Peptide Efficiently Promotes Corneal Wound Repairing and Lacrimal Secretion."
01/01/2015 - "Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries."
01/01/2015 - "However, the association of PACAP with hMSCs to protect nerve cells against neural injuries is still unclear. "
11/01/2005 - "We conclude that (i) 2 or 3 times PACAP treatment attenuates retinal degeneration; (ii) one PACAP treatment does not provide protection against repeated excitotoxic insults, and (iii) repeated application of PACAP under these experimental conditions may lead to a primed state in which further neurotoxic insults are ineffective."
08/01/2007 - "In summary, our present study provides evidence, for the first time, that PACAP attenuates ischemic retinal degeneration."
01/01/2012 - "Exogenous PACAP administration could partially protect against retinal degeneration in PACAP deficient mice. "
01/01/2012 - "We have provided evidence that PACAP is neuroprotective in several models of retinal degeneration in vivo. "
01/01/2011 - "Our results provide the basis for future clinical application of PACAP treatment in retinal degeneration and may have clinical implications in several ophthalmic diseases."
|4.||Brain Ischemia (Cerebral Ischemia)
06/01/2002 - "The aim of the present study was to investigate and compare the protective effects of PACAP and VIP in permanent focal cerebral ischemia in rats. "
01/01/2013 - "Expression and distribution of pituitary adenylate cyclase-activating polypeptide receptor in reactive astrocytes induced by global brain ischemia in mice."
01/01/2012 - "It has been shown that PACAP deficient mice have larger infarct size in cerebral ischemia. "
07/01/2010 - "Furthermore, PACAP-deficient mice have larger infarct volume in a model of cerebral ischemia, delayed axonal regeneration, and increased cell death in cerebellar oxidative stress. "
02/16/2010 - "Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia."
|5.||Brain Injuries (Brain Injury)
10/01/2015 - "This review provides an overview of current knowledge regarding the neuroprotective effects, mechanisms of action, and therapeutic potential of PACAP in response to ischemic brain injuries. "
04/01/2015 - "Exogenous PACAP38 confers a similar effect in facilitating BMDCs homing into the ischemic brain, resulting in reduction of ischemic brain injury. "
11/01/2014 - "PACAP38 suppresses cortical damage in mice with traumatic brain injury by enhancing antioxidant activity."
10/01/2014 - "PACAP has well-known neuroprotective potential including traumatic brain injury (TBI). "
10/01/2014 - "Changes of PACAP level in cerebrospinal fluid and plasma of patients with severe traumatic brain injury."
|1.||Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)
|4.||Sodium Glutamate (Accent)
|5.||Glutamic Acid (Glutamate)
|6.||Kainic Acid (Kainate)
|3.||Intensive Care (Surgical Intensive Care)