|1.||Billiar, Timothy R: 15 articles (12/2015 - 10/2006)|
|2.||Vogl, Thomas: 12 articles (07/2015 - 09/2007)|
|3.||Roth, Johannes: 12 articles (07/2015 - 09/2007)|
|4.||Watkins, Linda R: 12 articles (06/2015 - 07/2008)|
|5.||Hutchinson, Mark R: 12 articles (02/2015 - 07/2008)|
|6.||van der Poll, Tom: 10 articles (04/2015 - 08/2002)|
|7.||Netea, Mihai G: 10 articles (01/2015 - 07/2003)|
|8.||Hackam, David J: 9 articles (12/2015 - 06/2007)|
|9.||Maier, Steven F: 9 articles (04/2015 - 07/2008)|
|10.||Rice, Kenner C: 8 articles (06/2015 - 07/2008)|
02/01/2011 - "Here, we investigated whether an effect of HDL on Toll-like receptor 4 (TLR4) expression and signalling may contribute to its endothelial-protective effects and to improved survival in a mouse model of LPS-induced inflammation and lethality. "
09/01/2015 - "Persistent inflammation and impaired neovascularisation may be important contributors to the development of DR. A recent study showed that toll-like receptor 4 (TLR4) polymorphisms were associated with DR. The present study was designed to determine whether single-nucleotide polymorphisms (SNPs) in the TLR4 gene were associated with DR in a Chinese Han population. "
05/01/2015 - "In this study, we compared the effect of liver inflammation induced by the Toll-like receptor 4 ligand lipopolysaccharide (LPS) with that of a persistent virus, lymphocytic choriomeningitis virus (LCMV) clone 13, on early innate intrahepatic immune responses in mice. "
04/01/2015 - "However, several in vitro studies have reported that intestinal inflammation is caused by CGN and that this effect is mediated through Toll-Like-Receptor 4 (TLR4). "
02/01/2015 - "Because aging is considered as a state of low-grade inflammation, in this study we examined whether older, healthy (lean, community-dwelling) participants have altered signaling flux through toll-like receptor 4 (TLR4), a key mediator of innate and adaptive immune responses. "
|2.||Acute Lung Injury
01/01/2013 - "Toll-like receptor 4 mediates acute lung injury induced by high mobility group box-1."
12/01/2008 - "We hypothesized that bone components locally exposed to injured soft tissue are capable of inducing a systemic inflammatory response associated with acute lung injury, and that this inflammatory cascade requires Toll-like receptor 4 (TLR-4) signaling. "
04/18/2008 - "Here we report that Toll-like receptor 4 (TLR4) mutant mice display natural resistance to acid-induced acute lung injury (ALI). "
04/18/2008 - "Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury."
08/01/2007 - "Lipopolysaccharide (LPS) induces acute lung injury (ALI) via Toll-like receptor 4 (TLR4)-mediated MAPK activation. "
11/15/2013 - "The strain mutated for lppA had reduced ability to activate Toll-like receptor 4. Immunization of mice with the pal or lppA mutant provided protection against infection by the wild-type strain. "
03/01/2015 - "In this study, the subcellular localization, tissue distribution and response to grass carp reovirus (GCRV) infection and lipopolysaccharide (LPS) stimulation of four grass carp Ctenopharyngodon idellus toll-like receptor 4 (tlr4) genes were investigated. "
02/01/2013 - "This study aimed to verify whether rs4986790 A > G single nucleotide polymorphism of toll like receptor 4 (TLR-4) associates with a more severe course of hepatitis B virus (HBV) chronic infection. "
01/01/2013 - "This preliminary study aimed at assessing whether the in vitro proliferation of peripheral blood mononuclear cells in response to lipopolysaccharide permits individual characterization of periparturient dairy cows, and whether this parameter may be associated with incidence of infections and with some of the single nucleotide polymorphisms located on the toll-like receptor 4 (TLR4) gene. "
01/01/2007 - "To study experimental Neospora caninum infection initiated at the gastrointestinal tract, Toll-like Receptor 4- and functional IL-12Rbeta2 chain-deficient C57BL/10 ScCr mice were challenged intragastrically with 5 x 10(6) N. "
01/01/2008 - "In this study, we investigated the effect of probiotics on the development of experimental colitis using Toll-like receptor 4 (TLR-4) mutant (lps-/lps-) mice. "
10/01/2013 - "In colitis-associated carcinogenesis, the activation of nuclear factor-κB (NF-κB) occurs via lipopolysaccharide (LPS) binding to the toll-like receptor 4 (TLR4). "
01/01/2013 - "Modulating Toll-like receptor 4 signaling pathway protects mice from experimental colitis."
06/01/2009 - "A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis."
01/01/2013 - "We have previously demonstrated that toll-like receptor 4 (TLR4), the receptor for bacterial lipopolysaccharide (LPS), is over-expressed in humans with colitis-associated cancer. "
09/01/2015 - "In this study we tested the role of Toll-like receptor 4, the main receptor for endotoxin (LPS), in a mouse model of renal fibrosis and in a model of progressive CKD that better resembles the human disease. "
06/30/2013 - "This study evaluated the effect of probiotic-fermented purple sweet potato yogurt (PSPY) on the toll-like receptor 4 (TLR-4)-related inflammatory components, and on fibrosis in the heart of spontaneously hypertensive rat (SHR). "
03/01/2009 - "In a recent study, a single nucleotide polymorphism (SNP) of the Toll-like receptor 4 (TLR4) gene (c.1196C>T [rs4986791, p.T399I]) emerged as conferring protection from fibrosis progression compared to a major, wild-type (WT) CC allele (p.T399). "
05/22/2014 - "Continuous low-dose infusion of the Toll-like receptor 4 ligand, lipopolysaccharide, promotes adipose tissue fibrosis. "
05/22/2014 - "The presence of a functional Toll-like receptor 4 on adipose tissue hematopoietic cells is necessary for the initiation of adipose tissue fibrosis. "
|1.||NF-kappa B (NF-kB)
|3.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|4.||Interleukin-6 (Interleukin 6)
|7.||3- O- decyl- 2- deoxy- 6- O- (2- deoxy- 3- O- (3- methoxydecyl)- 6- O- methyl- 2- ((1- oxo- 11- octadecenyl)amino)- 4- O- phosphonoglucopyranosyl)- 2- ((1,3- dioxotetradecyl)amino)- 1- (dihydroxy phosphate)glucopyranose
|9.||monophosphoryl lipid A
|10.||Caspase 3 (Caspase-3)
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)
|3.||Drug Therapy (Chemotherapy)