|1.||Akira, Shizuo: 73 articles (08/2013 - 05/2002)|
|2.||Anders, Hans-Joachim: 22 articles (09/2015 - 03/2004)|
|3.||Flavell, Richard A: 21 articles (01/2015 - 07/2002)|
|4.||Medzhitov, Ruslan: 21 articles (03/2013 - 07/2002)|
|5.||Zacharowski, Kai: 18 articles (11/2015 - 11/2004)|
|6.||Kirschning, Carsten J: 16 articles (10/2015 - 10/2002)|
|7.||Szabo, Gyongyi: 16 articles (09/2013 - 11/2004)|
|8.||Wagner, Hermann: 16 articles (08/2012 - 11/2003)|
|9.||Netea, Mihai G: 15 articles (11/2015 - 05/2002)|
|10.||van der Poll, Tom: 15 articles (01/2015 - 12/2004)|
05/15/2015 - "Toll-like receptors (TLRs), important in rapid clearance of incident human papillomavirus (HPV) infections, may also be important in shaping the adaptive response to persistent infections. "
10/21/2008 - "Toll-like receptors (TLRs) may need to cooperate with each other to be effective in detecting imminent infection and trigger immune responses. "
12/01/2010 - "In order to elucidate the exact role of Toll-like receptor (TLR) or RIG-I-like receptor (RLR) signaling on immunogenicity and protective efficacy against influenza A virus infection (A/PR/8/34 [PR8]; H1N1), we adapted several innate signal-deficient mice (e.g., TRIF(-/-), MyD88(-/-), MyD88(-/-) TRIF(-/-), TLR3(-/-) TLR7(-/-), and IPS-1(-/-)). "
03/01/2012 - "Toll-like receptors (TLRs) are innate sentinels required for clearance of bacterial and fungal infections of the cornea, but their role in viral immunity is currently unknown. "
08/01/2010 - "Accumulating evidence suggests a role for Toll-like receptor (TLR) signaling at the intestinal epithelial cells (IECs) level for intestinal protection against exogenous injury or pathogenic infection. "
06/01/2010 - "The aim of the present study was to evaluate the therapeutic efficacy of dendritic cell (DC)-tumor fusion hybrids with Toll-like receptor (TLR) agonists. "
06/04/2009 - "In this study, we report that the lack of SRA/CD204 promotes Toll-like receptor (TLR)4 agonist-augmented tumor-protective immunity, which is associated with enhanced activation of CD8(+) effector T cell and improved inhibition of tumor growth. "
12/01/2015 - "Here, we evaluated the efficacy of maitake D-fraction, in combination with a Toll-like receptor agonist, to treat tumors in a murine model. "
06/30/2011 - "Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses."
12/02/2015 - "[Preliminary study on the expression of Toll-like receptors 7 and 8 in bladder urothelial tumors]."
08/01/2007 - "The recent discovery of toll-like receptors (TLRs), with their role as the initiators of the innate immune response and inflammation, suggests that modulating these receptors may be beneficial in the treatment of allergic disorders. "
01/15/2012 - "However, evidence has emerged that these compounds also have protective effects in some situations and cell types; a notable example is their ability to interfere with signaling by certain Toll-like receptors (TLRs) induced by microbial products that normally leads to inflammation. "
03/01/2015 - "Previous studies have demonstrated that soyasaponin (SoSa) possesses anti-inflammatory properties in lipopolysaccharide (LPS)-stimulated immune cells by influencing the immune sensing of toll-like receptor (TLR) 4. The aim of this study was to investigate the immune modulatory effect of SoSa I on TLR2- and TLR4-induced inflammation within the monocytic MUTZ-3-cell model. "
11/01/2012 - "To investigate the dose and time-dependent role of toll-like receptor (TLR) and Th1/Th2 shift in local and systemic inflammation induced by PM2.5, mice were subjected to intratracheal instillation of 2.5, 5, or 10 mg/kg PM2.5 in this study. "
10/01/2011 - "This study investigated the role of Toll-like receptor (TLR) 2, a pattern recognition receptor for gram-positive cell wall products, in regulating swine facility organic dust extract (DE)-induced airway inflammation in mice. "
08/01/2009 - "When administered after TNBS, this probiotic is also effective in accelerating colitis recovery, and this is associated with an enhanced Toll-like receptor function."
03/01/2005 - "A new study in this issue demonstrates a protective role for IFN-alpha/beta, induced by activation of a Toll-like receptor 9-dependent pathway, in a rodent model of experimental colitis."
01/01/2013 - "Although bacteria producing lipopolysaccharide (LPS), which is a Toll-like receptor (TLR) 4 agonist, play a crucial role in the development of experimental colitis, LPS tolerance following initial exposure to LPS can result in a state of hyporesponsiveness to subsequent LPS challenge. "
01/01/2012 - "Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(s) responsible for the development of colitis are currently unknown. "
11/01/2010 - "A disturbed regulation of Toll-like receptor (TLR) signal transduction resulting in the exclusive activation of proinflammatory signaling pathways may be critical for the perpetuation of established chronic colitis. "
|5.||Porcine Reproductive and Respiratory Syndrome (PRRS)
10/01/2013 - "Two decades ago, Toll like receptors (TLRs) family was known as one of the important PRRs with unique functions especially in protection against invading pathogens. "
09/01/2015 - "An important family of PRRs are the Toll-like receptors (TLRs) with numerous evidences indicating their crucial role in identifying microbial or viral compounds. "
04/01/2015 - "The Toll-like receptors (TLRs) are the best-described set of PRRs. "
03/01/2015 - "The sources of DAMPs are dead or dying cells or the extracellular matrix and can signal through the PRRs, the Toll-like receptors or cytosolic Nod-like receptors, culminating in nuclear factor κB (NF-κB) activation and pro-inflammatory cytokine secretion. "
09/01/2014 - "Toll-like receptors (TLRs), as members of pathogen recognition receptors (PRRs), play critical roles in the recognition of viruses and the induction of appropriate immune responses. "
|6.||Interleukin-6 (Interleukin 6)
|7.||Messenger RNA (mRNA)
|8.||ProMune (CpG 7909)
|10.||Pattern Recognition Receptors
|2.||Drug Therapy (Chemotherapy)