|1.||Hatzfeld, Mechthild: 3 articles (02/2014 - 08/2010)|
|2.||Wolf, Annika: 3 articles (02/2014 - 08/2010)|
|3.||van Roy, Frans: 2 articles (10/2015 - 04/2007)|
|4.||Hofmann, Ilse: 2 articles (09/2013 - 05/2010)|
|5.||Ströbel, Philipp: 2 articles (09/2013 - 05/2010)|
|6.||Sullu, Yurdanur: 2 articles (09/2012 - 01/2011)|
|7.||Yucel, Idris: 2 articles (09/2012 - 01/2011)|
|8.||Medina, Vanessa: 2 articles (06/2010 - 01/2008)|
|9.||Iglesias-Díaz, Pilar: 2 articles (06/2010 - 01/2008)|
|10.||Valladares-Ayerbes, Manuel: 2 articles (06/2010 - 01/2008)|
02/01/2014 - "Now, recent evidence sheds light on the post-translational regulation and provides an explanation for how de-regulation of plakophilins can contribute to cancer."
04/15/2013 - "This supports the view that the deregulation of plakophilin 1, as observed in several tumors, directly contributes to hyperproliferation and carcinogenesis in a context-dependent manner."
09/01/2012 - "Expression of Plakophilins (PKP1, PKP2, and PKP3) in breast cancers."
05/01/2012 - "Plakophilin-2: a cell-cell adhesion plaque molecule of selective and fundamental importance in cardiac functions and tumor cell growth."
08/01/2010 - "Given the importance of mRNA translation and protein synthesis in the development of cancer, we speculate that overexpressed plakophilin 1 could contribute to tumor formation. "
|2.||Circulating Neoplastic Cells
|3.||Gastrointestinal Neoplasms (Gastrointestinal Cancer)
|4.||Ectodermal Dysplasia (Aplasia Cutis Congenita)
03/01/2006 - "Skin fragility-ectodermal dysplasia syndrome is an autosomal recessive disorder caused by loss-of-function mutations in the desmosomal protein, plakophilin 1. Clinically, there may be considerable morbidity from extensive skin erosions and painful fissures on the palms and soles. "
08/15/2003 - "Ablation of the desmosomal plaque component plakophilin 1 underlies the autosomal recessive genodermatosis, skin fragility-ectodermal dysplasia syndrome (OMIM 604536). "
04/01/2002 - "Thus, the molecular findings help explain the clinical features in the patient, who has a similar but milder phenotype to previously reported patients with skin fragility-ectodermal dysplasia syndrome associated with complete ablation of plakophilin 1 (OMIM 604536). "
04/01/2002 - "Genotype-phenotype correlation in skin fragility-ectodermal dysplasia syndrome resulting from mutations in plakophilin 1."
11/01/1999 - "The clinical features of the affected individuals, who have total ablation of plakophilin 1, comprise a combination of skin fragility and ectodermal dysplasia with loss of hair, reduced sweating and nail dystrophy. "
|5.||Arrhythmogenic Right Ventricular Dysplasia (Arrhythmogenic Right Ventricular Cardiomyopathy)
01/01/2012 - "The desmosomal armadillo protein plakophilin 2 is the only plakophilin expressed in the heart, and mutations in the human plakophilin 2 gene result in arrhythmogenic right ventricular cardiomyopathy. "
05/01/2011 - "Plakophilin 2A is the dominant isoform in human heart tissue: consequences for the genetic screening of arrhythmogenic right ventricular cardiomyopathy."
08/01/2006 - "Arrhythmogenic right ventricular cardiomyopathy due to a novel plakophilin 2 mutation: wide spectrum of disease in mutation carriers within a family."
01/01/2014 - "According to nosology all patients were distributed in the following way: 1) chronic infectious-immune myocarditis (n=144, 75.7%), morphologically verified in 14, viral in 27 patients; 2) genetic cardiomyopathy (n=15, 7.9%), morphologically verified in 4, virus positive in 1 (arrhythmogenic right ventricular dysplasia, non-compaction myocardium, Fabri disease, Brugada syndrome, undetermined); in 4 patients mutations in plakophilin 2, desmoglein, desmin, -galactosidase A genes were found; 3) combination of genetic diseases with myocarditis (n=18; 9.5%) including viral (n=3); 4) isolated myocardiodystrophy (tonsillogenic< dyshormonal, n=3, 1.6%); 5) proper idiopathic arrhythmias (n=10, 5.3%). "
|2.||Proteins (Proteins, Gene)
|4.||Armadillo Domain Proteins
|9.||Transcription Factors (Transcription Factor)