HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Plakophilins

Members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.
Also Known As:
Band 6 Protein, Desmosomal; Desmosome Band 6 Polypeptide; Desmosome Band 6 Protein; Plakophilin 1; Plakophilin 2; Plakophilin 2a; Plakophilin 2b; Plakophilin 3; Plakophilin-3; Plakophilin
Networked: 114 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Cerrone, Marina: 5 articles (10/2021 - 07/2014)
2. Hatzfeld, Mechthild: 5 articles (01/2019 - 08/2010)
3. McGrath, John A: 5 articles (12/2007 - 07/2003)
4. James, Cynthia A: 4 articles (10/2021 - 11/2013)
5. Murray, Brittney: 4 articles (10/2021 - 11/2013)
6. Tichnell, Crystal: 4 articles (10/2021 - 11/2013)
7. Hofmann, Ilse: 4 articles (01/2020 - 05/2010)
8. Delmar, Mario: 4 articles (01/2019 - 10/2009)
9. Medeiros-Domingo, Argelia: 3 articles (10/2021 - 11/2020)
10. Mestroni, Luisa: 3 articles (10/2021 - 12/2019)

Related Diseases

1. Neoplasms (Cancer)
2. Cardiomyopathies (Cardiomyopathy)
3. Ectodermal Dysplasia-Skin Fragility Syndrome
4. Neoplasm Metastasis (Metastasis)
5. Brugada Syndrome
07/01/2014 - "We review evidence indicating that (1) loss of desmosomal integrity (including mutations or loss of expression of plakophilin-2; PKP2) leads to reduced sodium current (INa), (2) the PKP2-INa relation could be partly consequent to the fact that PKP2 facilitates proper trafficking of proteins to the intercalated disc, and (3) PKP2 mutations can be present in patients diagnosed with Brugada syndrome (BrS), thus supporting the previously proposed notion that AC and BrS are not two completely separate entities, but "bookends" in a continuum of variable sodium current deficiency and structural disease. "
01/01/2019 - "Although multiple conditions are addressed to illustrate these concepts, the experience obtained in the study of long-QT syndrome, Brugada syndrome, and arrhythmogenic cardiomyopathy, and in the study of functions related to SCN5A (the gene coding for the α-subunit of the most abundant sodium channel in the heart) and PKP2 (the gene coding for the desmosomal protein plakophilin-2), as well, is discussed in more detail."
01/01/2014 - "According to nosology all patients were distributed in the following way: 1) chronic infectious-immune myocarditis (n=144, 75.7%), morphologically verified in 14, viral in 27 patients; 2) genetic cardiomyopathy (n=15, 7.9%), morphologically verified in 4, virus positive in 1 (arrhythmogenic right ventricular dysplasia, non-compaction myocardium, Fabri disease, Brugada syndrome, undetermined); in 4 patients mutations in plakophilin 2, desmoglein, desmin, -galactosidase A genes were found; 3) combination of genetic diseases with myocarditis (n=18; 9.5%) including viral (n=3); 4) isolated myocardiodystrophy (tonsillogenic< dyshormonal, n=3, 1.6%); 5) proper idiopathic arrhythmias (n=10, 5.3%). "

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Desmoplakins (Desmoplakin)
3. gamma Catenin (Plakoglobin)
4. Cadherins (E-Cadherin)
5. Sodium Channels (Sodium Channel)
6. Biomarkers (Surrogate Marker)
7. Monoclonal Antibodies
8. Plakophilins
9. Desmoglein 2
10. Desmocollins