Desmocollins

A group of desmosomal cadherins with cytoplasmic tails that are divergent from those of classical CADHERINS. Their intracytoplasmic domains bind PLAKOGLOBIN; PLAKOPHILINS; and DESMOPLAKINS.

Also Known As:

Networked: 161 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hashimoto, Takashi: 28 articles (01/2022 - 12/2003)
2.	Ishii, Norito: 18 articles (01/2021 - 12/2010)
3.	Hashimoto, T: 17 articles (07/2016 - 11/2000)
4.	Ishii, N: 10 articles (12/2022 - 01/2004)
5.	Koga, Hiroshi: 10 articles (01/2021 - 07/2011)
6.	Teye, Kwesi: 8 articles (01/2021 - 05/2013)
7.	Koga, H: 6 articles (12/2022 - 01/2013)
8.	Teye, K: 6 articles (07/2015 - 04/2013)
9.	Chen, Yuan: 5 articles (01/2019 - 11/2011)
10.	Petersen, Iver: 5 articles (01/2019 - 11/2011)

Related Diseases

1.	Pemphigus (Pemphigus Vulgaris) 12/01/2021 - "Mucosa-predominant pemphigus vulgaris with anti-desmocollin 2 and 3 antibody positivity and ocular symptoms." 12/01/2010 - "Six of 38 pemphigus vulgaris and one of 85 normal serum samples immunoprecipitate desmocollin 3 (P = 0.003). " 12/01/2010 - "Autoimmunity to desmocollin 3 in pemphigus vulgaris." 10/30/2009 - "Desmocollin 3-mediated binding is crucial for keratinocyte cohesion and is impaired in pemphigus." 04/01/1995 - "We present a 38-year-old Japanese male who showed clinically and histopathologically typical features of pemphigus vulgaris, whose sera reacted with all PVA, PFA, and desmocollins using immunoblotting of both human epidermis and bovine snout epidermis. "
2.	Colonic Neoplasms (Colon Cancer) 09/01/2008 - "Repression of the desmocollin 2 gene expression in human colon cancer cells is relieved by the homeodomain transcription factors Cdx1 and Cdx2." 07/22/2019 - "MLS128 antibody-induced suppression of colon cancer cell growth is mediated by a desmocollin and a 110 kDa glycoprotein." 11/01/2012 - "Furthermore, mRNA expression of desmocollins was evaluated in eight colon cancer cell lines. "
3.	Breast Neoplasms (Breast Cancer) 03/16/2023 - "In the present study, we describe the pro-metastatic role of the desmosomal protein desmocollin 2 (DSC2) in breast cancer. " 01/04/2007 - "Two examples include the antimetastatic, tumor suppressor genes, desmocollin 3 (DSC3) and MASPIN, which are frequently silenced in this manner in human breast cancer. " 07/01/2001 - "Down-regulation of the desmosomal cadherin desmocollin 3 in human breast cancer." 06/05/2003 - "Gene-profiling experiments of breast cancer cells infected with wt p53 revealed both MASPIN and desmocollin 3 (DSC3) to be p53-target genes, even though both genes are silenced in association with aberrant cytosine methylation of their promoters. " 07/01/2001 - "Northern analysis, quantitative real-time polymerase chain reaction assay and Western blot analysis showed that desmocollin 3 is present in normal and immortalized human mammary epithelial cells, but consistently exhibits a significant, and often complete, down-regulation in breast cancer cell lines and primary breast tumors, both at the mRNA and protein levels."
4.	Atherosclerotic Plaque (Atheroma) 01/01/2021 - "Objective: Our recent studies showed that desmocollin 1 (DSC1) binds to apoA-I in order to inhibit apoA-I-mediated high density lipoprotein (HDL) biogenesis in atherosclerotic plaques. " 01/01/2018 - "We have recently shown that desmocollin 1 (DSC1) acts as an apolipoprotein (apo) A-I binding protein that is highly expressed in atherosclerotic plaques and inhibits atheroprotective HDL functions by retaining apoA-I. The apoA-I retention hypothesis proposes that macrophages express DSC1 in a maladaptive process that renders apoA-I inactive and contributes to atherosclerosis. "
5.	Melanoma (Melanoma, Malignant) 01/01/2022 - "Connexins, laminins and desmocollins have been implicated in the control of melanoma growth, where their reduced expression has been reported in metastatic lesions. " 03/01/2011 - "The expression of desmocollin 3 and connexin 43 in melanomas indicates loss of cell-cell interactions, which starts in the early steps of the melanoma progression model. " 03/01/2011 - "The expression of desmocollin 3 and connexin 43 was higher in melanomas (P < .001). " 03/01/2011 - "Based on a previous study using a complementary DNA microarray platform, the aim of this study was to evaluate the immunohistochemical expression of the adhesion and communication molecules connexin 43, desmocollin 3, cytokeratin 5, kallikrein 6, and kallikrein 7 in a melanoma progression model. "

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Autoantibodies
3.	Transcription Factors (Transcription Factor)
4.	Antibodies
5.	Immunoglobulin A (IgA)
6.	Proteins (Proteins, Gene)
7.	Complementary DNA (cDNA)
8.	HDL Lipoproteins
9.	Keratin-5 (Keratin 5)
10.	Apolipoprotein A-I (Apolipoprotein A1)

Related Therapies and Procedures

1.	Radiotherapy