|1.||Saffitz, Jeffrey E: 8 articles (09/2013 - 05/2004)|
|2.||Asimaki, Angeliki: 7 articles (09/2013 - 09/2006)|
|3.||McKenna, William J: 7 articles (10/2011 - 05/2004)|
|4.||Thiene, Gaetano: 6 articles (09/2013 - 11/2002)|
|5.||Basso, Cristina: 6 articles (09/2013 - 11/2002)|
|6.||Protonotarios, Nikos: 5 articles (10/2011 - 05/2004)|
|7.||Tsatsopoulou, Adalena: 5 articles (10/2011 - 05/2004)|
|8.||Syrris, Petros: 4 articles (04/2011 - 09/2006)|
|9.||Wichter, Thomas: 4 articles (02/2011 - 12/2002)|
|10.||Hardisson, David: 4 articles (08/2006 - 11/2002)|
01/01/2012 - "In this study, we demonstrate a functional role for plakoglobin in the shedding of tumor cells from the primary site into the circulation. "
08/28/2014 - "Thus, CTC clusters are derived from multicellular groupings of primary tumor cells held together through plakoglobin-dependent intercellular adhesion, and though rare, they greatly contribute to the metastatic spread of cancer."
08/01/2013 - "Although mutations in the plakoglobin gene (Jup) and/or changes in its protein levels have been observed in various disease states, including cancer progression or cardiovascular defects, the information about endogenous or exogenous stimuli orchestrating Jup expression is limited. "
08/01/2013 - "Plakoglobin is an important component of intercellular junctions, including both desmosomes and adherens junctions, which is known as a tumor suppressor. "
01/01/2013 - "In conclusion, we found that DSG3 functions as an oncogene and facilitates cancer growth and invasion in HNC cells through the DSG3-plakoglobin-TCF/LEF pathway."
11/01/2002 - "In conclusion, ATRA and CAT show anti-metastatic potential in the invasive rat prostate adenocarcinoma model and gamma-catenin appears to play a mechanistic role."
11/01/1998 - "We examined the expression of E-CD and alpha-, beta- and gamma-catenin immunohistochemically in 18 BACs (9 mucinous, 7 nonmucinous, and 2 sclerosing) in comparison with CPAs, all of which were well-differentiated adenocarcinomas. "
04/01/1998 - "Deficient plakoglobin expression on the primary tumor was significantly correlated to a shortened disease-free and overall survival in patients with adenocarcinomas, pT1-2 tumors, or negative lymph nodes (pN0). "
01/01/2007 - "p120 and gamma-catenin displayed membranous staining in 100% of tubulolobular and tubular carcinomas and cytoplasmic staining in 100% of lobular carcinomas. "
02/01/2006 - "Expression of CD44v6 and nuclear beta- and gamma-catenin were detected only in borderline tumors and adenocarcinomas. "
06/20/2005 - "In this study, we directly addressed the question of the role of plakoglobin in bladder tumorigenesis following restoration, or knockdown of expression in bladder carcinoma cell lines. "
10/01/2004 - "In this study, we investigated the clinical relevance of alpha-, beta-, and gamma-catenin immunoexpression in 104 cases of primary ovarian carcinoma with respect to clinicopathological features and as predictors of disease recurrence and prognosis. "
01/01/2013 - "Finally, plakoglobin expression resulted in decreased in vitro proliferation, migration and invasion in different carcinoma cell lines. "
01/01/2013 - "These results were confirmed following plakoglobin expression in the very low plakoglobin expressing and invasive mammary carcinoma cell line MDA-MB-231 cells (MDA-231-PG). "
01/01/2013 - "Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. "
|4.||Neoplasm Metastasis (Metastasis)
01/01/2013 - "Together with the results of our previous studies, the data suggests that plakoglobin suppresses tumorigenesis and metastasis through the regulation of genes involved in these processes. "
08/28/2014 - "In mouse models, knockdown of plakoglobin abrogates CTC cluster formation and suppresses lung metastases. "
01/01/2012 - "In this paper, we describe plakoglobin, its discovery and characterization, its role in regulating cell-cell adhesion, and its signaling capabilities in regulation of tumorigenesis and metastasis."
01/01/2012 - "The exact roles that plakoglobin plays during tumorigenesis and metastasis are not clear; however, recent evidence suggests that it may regulate gene expression, cell proliferation, apoptosis, invasion, and migration. "
01/01/2012 - "Plakoglobin: role in tumorigenesis and metastasis."
|5.||Breast Neoplasms (Breast Cancer)
06/01/2015 - "Here, we aim to summarize the studies on the roles of plakoglobin and evaluate the association of plakoglobin and breast cancer survival. "
06/01/2012 - "This study thus implicates SLUG-induced repression of plakoglobin as a motility determinant in highly disseminating breast cancer."
07/01/2000 - "In this study, we screened 24 human breast cancer cell lines and three immortalized human breast epithelial cell lines for alterations in beta- and gamma-catenin and APC by western blotting, protein truncation assay and DNA sequence analysis. "
06/01/2015 - "Plakoglobin may be a potential prognostic biomarker that can be exploited to develop as a therapeutic target for breast cancer. "
06/01/2015 - "Finally, based on an open-access database, the association between plakoglobin and breast cancer survival was investigated using univariate and multivariate survival analyses. "
|2.||Proteins (Proteins, Gene)
|4.||alpha Catenin (alpha E-Catenin)
|6.||Messenger RNA (mRNA)
|4.||Heterologous Transplantation (Xenotransplantation)