Plakins

A family of related proteins that associate with cytoskeletal elements and junctional complexes at INTERCELLULAR JUNCTIONS. Plakins share a common plakin domain or a plakin repeat domain.

Also Known As:

Networked: 23 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Hashimoto, T: 2 articles (11/2013 - 02/2000)
2.	Liem, Ronald K H: 2 articles (02/2007 - 01/2002)
3.	Bolling, Marieke C: 1 article (09/2021)
4.	Bungener, Laura B: 1 article (09/2021)
5.	Diercks, Gilles F H: 1 article (09/2021)
6.	Fidder, Sander A R: 1 article (09/2021)
7.	Hooimeijer, Louise H L: 1 article (09/2021)
8.	Pas, Hendri H: 1 article (09/2021)
9.	Scheenstra, Rene: 1 article (09/2021)
10.	Stapelbroek, Janneke M: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 03/24/2018 - "Here, we introduce the basic characteristics of mammalian plakins, review the recent advances in understanding their biological functions, and highlight their roles in human cancers, based on studies performed by us and others. " 03/24/2018 - "As these cellular processes are key steps in cancer development, mammalian plakins have in recent years attracted more and more attention for their potential roles in cancer. " 03/24/2018 - "Mammalian Plakins, Giant Cytolinkers: Versatile Biological Functions and Roles in Cancer." 01/26/2018 - "Plakins have been found to be involved in disorders and diseases of the skin, heart, nervous system, and cancer that are attributed to autoimmune responses and genetic alterations of these macromolecules. " 03/24/2018 - "This will provide researchers with a comprehensive understanding of mammalian plakins, new insights into the development of cancer, and novel targets for cancer diagnosis and therapy."
2.	Pemphigus (Pemphigus Vulgaris) 01/01/2015 - "Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous blistering disease driven by autoantibodies against plakins expressed in mucosal epithelium. " 12/01/2011 - "El Bagre-EPF patients share several autoantigens with paraneoplastic pemphigus patients, such as reactivity to plakins. " 01/01/2022 - "Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease associated with underlying neoplasms and characterized by antibodies against desmoglein 3 (Dsg 3) and plakins. " 04/01/2012 - "Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associated with lymphoproliferative neoplasms and characterized by antibodies against plakins and desmoglein 3 (Dsg3). " 08/01/2020 - "Moreover, BIOCHIP mosaic also demonstrated a high degree of consistency for the detection rate of anti-Dsg1, Dsg3, plakins, BP180-NC16A-4X and non-collagenous domain of type VII collagen autoantibodies for the diagnosis of pemphigus foliaceus (77.3%), pemphigus vulgaris (88.6%), paraneoplastic pemphigus (100.0%), bullous pemphigoid (92.8%) and epidermolysis bullosa acquisita (99.0%), respectively. "
3.	Bullous Pemphigoid (Pemphigoid) 02/09/2007 - "Structural analysis of the plakin domain of bullous pemphigoid antigen1 (BPAG1) suggests that plakins are members of the spectrin superfamily." 11/01/2010 - "Epiplakin (EPPK) belongs to the plakin family of cytolinker proteins and, resembling other members of the plakin family such as BPAG1 (an autoantigen of bullous pemphigoid) and plectin, EPPK has plakin repeat domains (PRDs) that bind to intermediate filaments. " 08/01/2020 - "Moreover, BIOCHIP mosaic also demonstrated a high degree of consistency for the detection rate of anti-Dsg1, Dsg3, plakins, BP180-NC16A-4X and non-collagenous domain of type VII collagen autoantibodies for the diagnosis of pemphigus foliaceus (77.3%), pemphigus vulgaris (88.6%), paraneoplastic pemphigus (100.0%), bullous pemphigoid (92.8%) and epidermolysis bullosa acquisita (99.0%), respectively. " 12/01/2017 - "Targeted proteins include the two intracellular plakins, plectin isoform 1a and BP230 (also called bullous pemphigoid antigen (BPAG) 1 isoform e (BPAG1e)). " 01/26/2018 - "Plakins are a family of seven cytoskeletal cross-linker proteins (microtubule-actin crosslinking factor 1 (MACF), bullous pemphigoid antigen (BPAG1) desmoplakin, envoplakin, periplakin, plectin, epiplakin) that network the three major filaments that comprise the cytoskeleton. "
4.	Drug Hypersensitivity Syndrome 11/01/2016 - "Longitudinal analysis of antibody profiles against plakins in severe drug eruptions: emphasis on correlation with tissue damage in drug-induced hypersensitivity syndrome and drug reaction with eosinophilia and systemic symptoms."
5.	Peripheral Nerve Injuries 07/01/2012 - "The robust axon regeneration that occurs following peripheral nerve injury is driven by transcriptional activation of the regeneration program and by the expression of a wide range of downstream effector molecules from neuropeptides and neurotrophic factors to adhesion molecules and cytoskeletal adaptor proteins. "

Related Drugs and Biologics

1.	Plectin
2.	Autoantibodies
3.	Proteins (Proteins, Gene)
4.	Antigens
5.	Antibodies
6.	Desmoglein 3
7.	Desmogleins
8.	Autoantigens
9.	epiplakin
10.	envoplakin

Related Therapies and Procedures

1.	Therapeutics