Wnt Proteins

Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.

Also Known As:

Networked: 151 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Virshup, David M: 3 articles (01/2021 - 03/2015)
2.	Li, Junzhe: 2 articles (01/2022 - 01/2020)
3.	Xu, Shijie: 2 articles (01/2022 - 01/2020)
4.	Xu, Xianhua: 2 articles (01/2022 - 01/2020)
5.	Cervi, Laura: 2 articles (12/2021 - 01/2018)
6.	Fozzatti, Laura: 2 articles (12/2021 - 01/2018)
7.	Motran, Claudia Cristina: 2 articles (12/2021 - 01/2018)
8.	Volpini, Ximena: 2 articles (12/2021 - 01/2018)
9.	Willert, Karl: 2 articles (01/2021 - 09/2012)
10.	Yu, Jia: 2 articles (01/2021 - 03/2015)

Related Diseases

1.	Autosomal Dominant Polycystic Kidney (ADPKD) 01/01/2018 - "Pharmacologically inhibiting β-catenin stability or the production of mature Wnt protein, or genetically reducing the expression of Ctnnb1 (which encodes β-catenin), suppressed the formation of renal cysts, improved renal function, and extended survival in ADPKD mice. " 02/19/1999 - "Renal tubulogenesis requires the presence of certain Wnt proteins, whereas mutations in polycystin impede the terminal differentiation of renal tubular epithelial cells, causing the development of large cystic kidneys that characterize autosomal dominant polycystic kidney disease. "
2.	Cysts 01/01/2018 - "Pharmacologically inhibiting β-catenin stability or the production of mature Wnt protein, or genetically reducing the expression of Ctnnb1 (which encodes β-catenin), suppressed the formation of renal cysts, improved renal function, and extended survival in ADPKD mice. "
3.	Neoplasms (Cancer) 02/24/2014 - "In the present study, we investigated the expression of wnt protein and the concordance rate in primary tumor and metastatic sites in CRC. " 09/01/2012 - "Although our understanding of the role of Wnt signaling in regulating development and affecting disease, such as cancer, has been ever increasing, the study of the Wnt proteins themselves has been painstaking and slow moving. " 01/01/2019 - "Wnt signaling plays fundamental roles in organogenesis, tissue regeneration and cancer, but high-resolution structural information of mammalian Wnt proteins is lacking. " 01/01/2019 - "A subset of primary GBM-derived stem cells requires Wnt proteins for self-renewal, and this subset specifically relies on Wnt/βcatenin signaling for enhanced tumor burden in xenograft models. " 07/01/2018 - "Wnt proteins have been reported to contribute to the progression of various types of cancer. "
4.	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/01/2022 - "Our study identified Wnt proteins and Wnt/β-catenin signaling in pulmonary fibrosis in vitro and in vivo, and highlighted Wnt8b as a potential therapeutic target in pulmonary fibrosis. " 09/01/2012 - "Recent studies suggest the importance of the transition of airway epithelial cells (EMT) in pulmonary fibrosis, and also indicate a role for Wingless protein (Wnt)/β-catenin signaling in idiopathic pulmonary fibrosis. "
5.	Cicatrix (Scar) 06/28/2022 - "In this study, the expression and localization of Wnt proteins in a mouse fetal-wound-healing model and their associations with scar formation were analyzed. " 01/01/2010 - "The authors' study aimed to establish a correlation between beta-catenin-dependent (canonical) Wnt protein, transforming growth factor (TGF)-beta1, and the expression of hyaluronan synthesis enzymes during scarless versus scarring wound healing. "

Related Drugs and Biologics

1.	Catenins
2.	beta Catenin
3.	Ligands
4.	Transforming Growth Factors (Transforming Growth Factor)
5.	Hyaluronic Acid (Hyaluronan)
6.	Enzymes
7.	Proteins (Proteins, Gene)
8.	Frizzled Receptors
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Acupuncture Therapy