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Methionine Sulfoxide Reductases

Reductases that catalyze the reaction of peptide-L-methionine -S-oxide + thioredoxin to produce peptide-L-methionine + thioredoxin disulfide + H(2)O.
Also Known As:
Methionine Sulfoxide Reductase A; Methionine Sulfoxide Reductase B; Methionine-R-sulfoxide Reductases; Peptide-Methionine (S)-S-oxide Reductase; SelR Protein; Methionine R sulfoxide Reductase; Methionine R sulfoxide Reductases; Reductase, Methionine-R-sulfoxide; Reductases, Methionine Sulfoxide; Reductases, Methionine-R-sulfoxide; Sulfoxide Reductases, Methionine; Methionine-R-sulfoxide Reductase; Peptide-Methionine (R)-S-oxide Reductase; Selenoprotein R
Networked: 59 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Kim, Jee In: 3 articles (01/2021 - 06/2013)
2. Park, Kwon Moo: 3 articles (01/2021 - 06/2013)
3. Grumbach, Isabella M: 3 articles (01/2018 - 11/2011)
4. Moskovitz, Jackob: 3 articles (01/2018 - 07/2007)
5. Spitz, Douglas R: 3 articles (01/2018 - 05/2008)
6. Kim, Hwa-Young: 3 articles (10/2017 - 06/2013)
7. Cao, Jia: 2 articles (01/2020 - 10/2015)
8. Fan, Hua: 2 articles (01/2020 - 04/2015)
9. Yu, Hong: 2 articles (01/2020 - 10/2015)
10. Koval, Olha M: 2 articles (01/2018 - 11/2011)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Obesity
03/01/2013 - "Recently, several genome-wide analyses have found human obesity to be strongly correlated with polymorphisms near the methionine sulfoxide reductase A (MsrA) locus. "
11/01/2010 - "There is evidence that waist circumference and waist-hip ratio in the Caucasian population are associated with variations in several genes, including neurexin 3 (NRXN3), transcription factor AP-2β (TFAP2B), methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes. "
01/01/2015 - "We previously identified that mice lacking the protein oxidation repair enzyme methionine sulfoxide reductase A (MsrA) are particularly prone to obesity-induced insulin resistance suggesting an unrecognized role for this protein in metabolic regulation. "
06/01/2014 - "This study aims to test whether 10 polymorphisms in obesity-related genes methionine sulfoxide reductase A (MSRA), transcription factor AP-2 beta (TFAP2B), melanocortin 4 receptor (MC4R), neurexin 3 (NRXN3), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), transmembrane protein 18 (TMEM18), homolog of S. "
04/22/2010 - "Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen 8 gene; p = 1.85x10(-8) in the DISCOVERY step) and one between TNKS (tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase gene) and MSRA (methionine sulfoxide reductase A gene; p = 4.84x10(-7)), the latter finding being limited to children and adolescents as demonstrated in the GENERALIZATION step. "
3. Inflammation (Inflammations)
4. Cataract (Cataracts)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Hydrogen Sulfide (Sulfide, Hydrogen)
2. Histone Deacetylases (Histone Deacetylase)
3. Proteins (Proteins, Gene)
4. Enzymes
5. Antioxidants
6. methionine sulfoxide
7. Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)
8. Thioredoxins
9. Scavenger Receptors (Scavenger Receptor)
10. Transcription Factor AP-2

Related Therapies and Procedures

1. Lenses